178 supplements analyzed and ranked by clinical evidence.
Probiotics: fewer infections
Immune calming + barrier
Gut barrier - intestinal permeability
Immune defense - infections -20%
Immuneâ Tregs
Inflammationâ IL-6
infectionâ 44%
Immune markers +13%
+T cells 12%
Immune boost, fewer infections
Immune suppression, fewer flares
Immune support: -85% infection
Immune support: -13% sores
Inflammationâ, EPAâ
Complicationsâ, infectionsâ
Bifido+SCFA, âinflammation
Fewer infections, better immunity
Higher immunity +30-90%
More reactogenicity
Boosted immune cells
Reduced inflammation/oxidation
Inflammationâ IL-6/TNF
Infectionsâ, vaccineâ
Immune support:+54% seroconversion
Immune support:fewer infections
Lower inflammation, more nâ3
Immune function shifts
Allergy/immune tolerance
+46.6% GSH
Lower IL-6; anti-inflammatory
+70% C, better immunity
Immune markers + infections
T-cell support + less infection
Inflammation down, immunity up
Immune recovery +26.7%
Infections down 26%
T-cell markers up
Milk antibodies, cytokines
Immune transfer, ±10%
Mucosal IgA, +79%
Immune cellsâ, infectionsâ
CRPâ, arginineâ
HIV/CD4: +2.24 risk
Less malaria/anemia: â69%
Immune cells/cytokines: faster clearance
Butyrateâ immune markers
LPS/inflammationâ butyrateâ
Lower LTB4/LTE4
AAâEPA/DHA shift
Immune support +14%
GSHâ, immune function
Oxidative/inflammationâ, infectionsâ
Inflammationâ immune support
Treg/antioxidantâ immune support
Immune cells +151
Infections â30%
Immune support, fewer infections
Immune support, faster recovery
GSHâ, immune survival
Inflammationâ, outcomesâ
Anti-inflammatory, gut SCFA
Vaccine antibodies, +10â80%
Immune boost: IgA, T-cells
+35% NK/Phagocytosis
Sepsis/NEC â 46%
Sore throat/cold â 68%
Fewer infections, shorter illness
Lower inflammation, better immunity
âçç/ć ç« markers
âairway/respiratory immune reactivity
Inflammationâ, immunityâ
Mortalityâ, immunityâ
T-cell boost
WBC increase
Cytokine balance
Inflammation/oxidative stress â
Antiviral/immune response â
Infection outcomes â
Antibody/T cell boost
Rhinitis/asthma relief
Immune recovery + complications
Infections â, HLA-DR/TNF-α â
Respiratory/infection â
Inflammation/immune â
ALT/AST, immuneâ
Infections, immune defenseâ
T-cells, responseâ
Immune markers â65%
Inflammation/cytokines reduced
Lower copper, weaker immunity
Fewer infections, better wounds
âImmune markers with copper
Immune/infection â, +5âfold folate
Inflammation â, homocysteine â22%
Neutropenia â, WBC +
NK/T cells +43%
Respiratory infections -45%
Basophils -65%
Nasal symptoms -p
Inflammation markers -p
Immune activation +
Inflammation -59% IL-1ÎČ
Catheter infections 0 cases
WBC/CRP improvement
Gut barrier/endotoxin â
Inflammation markers â
Antiviral immunity +20â70%
Warriors, less infections
Gut barrier, microbiota
Inflammation/antiviral boost
Immune cells/antibodies
Lower inflammation
Boosts immune regulation
Leukocyte/antibody boosts
â55% antiâTPO
â34pp mucositis
Immune markers + B12
Inflammation â, antibodies â
Immune boost, infections â
Cytokines/ALT, +23% remission
Immune cells + pathogens
Cold infections â41-58%
NK/cytokines â
Infections/colds â
Allergy symptom relief
CD4/viral load support
Inflammation down, IL-10 up
Myoglobin down, immune balance
Immune markers +
Gum inflammation â
Infection/inflammation â
Inflammation down
Endotoxin/immune markers down
Blood pressure down
Skin improvement, ~50%
T-cell shift, no morphology
DLQI -5.9, PASI75 37.5%
Inflammation down, IL-1ÎČ/IL-6
CRP/ESR down, TNF-α
Allergy symptoms/IgE
Crohnâs inflammation/remission
Mucosal/immune protection â
Oxidative stress -65%
Inflammation/infection â
Inflammation â; IL-4/IL-6
Immune balance â; IFN-Îł
Fewer infections, +antibodies
Immune activation, +IgA/IgG
Omegaâ3â; inflammationâ
Liver markers stable
Inflammationâ, IFN-Îł
Oxidative stressâ, 8-isoprostane
Immune cellsâ, IL-10
Fewer infections, shorter duration
NK activity â
Inflammation â
Inflammation genes â
Glucose/IL-6 â
Immune activation+antibodies
T-cell suppression
Reduced inflammation
Immune marker gains
Immune shifts, modestly â
MBL/activity changes, risk
Proline/arginine â; immunity +
Antibodies â; inflammation â
Immune markers +10%
Immune suppression -5
Ornithine â; lymphocytes â
Infections â; stay â
Immune markers â
Antibody boost +8.08
Cold/tonsillitis fewer cases
â Salmonella 2â4 log
â immune organs/lymphocytes
Immune cells up
Viral reactivation down
CD4+ 60%â37.5%
Anti-inflammatory, antioxidant support
+oocyte outcomes
Cytokines/oxidative stress -
Innate immunity â (NK +34%)
Post-transplant infections â (â10.8%)
UTI defense â51%
Immune cell boost
Lower sting reactions -8%
Higher tolerance markers
Immune recovery
-50% ARDS
Flu protectionâ 73%
Inflammation â
Amino acids + serine
Immune markers +29%
Immune cells + response
+41% tumor response
Antibody/platelet support
Faster URI recovery
UV immune protection
â IL-8, âNAD+
T-cell shifts
Fatigue relief
Lower inflammation; -60%
Boosted antiviral response; +38%
âInflammation markers
âImmune cells
Anti-inflammatory genes
âIL-1/TNF-α
Immune/allergy relief
Allergy relief, IgE â100
Inflammation control, CRP/ESR â
Lymphocytes, +8.9 kg
NK/IL-6, +34.1%
Warts, +11.9 pp
Immune markers â27.9%
Symptoms, inflammation â
Inflammation â; O2sat +4.8
Immune/eradication â; +9.0
Throat/nasal relief +53%
Overall symptoms improved 2.1x
Earache/runny nose reduced
Immune illnessâ
Infectionsâ 29-38%
Better autonomic, viral markers
Inflammation, CRP â59%
UTI risk â55%
Cold incidence -
Tetanus IgG +
Cough â, recovery faster
NK, IgG/IgA/IgM â
Immune recovery +28%
Inflammation/allergy â1.7d
Better immune markers
â T-cell activation
â IgA/IgM; â cytokines
Omega-3â, immune cellsâ
Disease activityâ, +3.6% Omega-3
Inflammation -IL-6, TNF-α
Antibacterial support -streptococci
Immune signaling + cells
NLR -reduced
Immune markers down
IL-8 â52.6%
Cytokines down
HPV clearance +14.4%
Inflammation/SpO2 +4.6%
Cu/Se raise immunity
Hepcidin +1.5x, DMT1â
JAK/STAT â; autophagy â
Viral clearance â; CD4 recovery â
Symptoms â
IL-6 -55.5%
better cytokine balance
Immune markers â, +50% TGF-ÎČ1
MDRO/AMR burden â, A. muciniphila
Symptoms improved, no safety issues
Inflammation â; IL-6/8/TNF-α
Immune illness â; 28%
Leukopenia response +85%
Rescue use -3.09
â inflammation, â microbes
â plaque/bleeding, pathogens
Immune markers improved
EDSS better, PUFAs
TNF-α/MDA â
Cytokines shifted
RBC preserved
QoL, ABU +26%
Hospital stay â0.95d
Immune modulation: IFN-Îł
Inflammation relief: â3.29 SCCAI
DNA damage -40%
T-cells/carotenoids +30%
âoral pathogens, acid
âIL-17A (~4.4x)
IL-6, IFN-Îł â
No lipid/glucose change
Immune marker up
Respiratory events -29.6%
Immune signalling â43%
Allergic activation â65%
Reduced airway inflammation
Better asthma control
Symptoms -57%
IgE/IgG4 shift
IL-1ra/5/7 â
IgE & symptoms â
H. pylori, inflammation
NK granzyme B +
HPV clearance 88%
Milk +3.3 kg/day
Antibody/PBMC/IFN-Îł â
Mortality/rehospitalization â13.3%
Shorter stay +86%
NK + IFN-Îł boost
hsCRP â8.4%
Sore throat relief, 81.6% responders
Earlier antipyretic stop, faster recovery
CD4 +84 cells/”L
No VL or weight change
COVID-19 risk -55%
Mild side effects
TgAb down -46.2
More side effects +37%
NK activity +12%
IFN-Îł +1.7 pg/mL
â inflammatory markers
â TG/VLDL
Anti-inflammatory oxylipins +
Lower IL-6/IL-8
Skin lesions improved
S. aureus inhibited
Endotoxin/MMP-9/IL-18 â
Response rate +21.6%
Clearance +21â40%
T/NK + cytokines
Clearance +20%
Cytokines, T-cells up
Function +0.105; activity
Physician/RAQoL/SF-12 improved
Immune vigor, CD4+ T cells
Total/naĂŻve T cells increased
Oral hygiene +0.7
Periodontal scores -1.0
Anti-inflammatory â21% CRP
Oxidative defense +Nrf2
Giardia cleared 100%
Symptoms improved
Relapse/lesion reduction
EDSS/MSFC improved
SNOT-22 -11.6 points
Endoscopic improvement
Vitamin A, antibodies +68%
+128% response, 0% weak
âbeta-cell, âIFN-Îł
âinsulin dose, âIL-4
ILâ1ÎČ â; symptom relief
No eradication effect
Urticaria - lower UAS7
Quality/sleep better
Acute phase â2 days
Recovery QoL, mental
CRP down; CD4 up
IL-1α/ÎČ up
WBC/neutrophils drop less
-13.4% vs -31.5%
T cells unchanged
HDL up, CRP -15%
Triglycerides -15%, Lp-PLA2 -20%
Inflammation -30â66%
Blood pressure/LDL -8%
SIgA +41%/+37%
NK/Th1 cytokines increased
UroA/butyrateâ CRPâ
Naive CD8â metabolism shift
Immune cells shifted +
Bile acids increased
Inflammation -59%
DNA protection ~90%
UTI recurrence -70%
Urgency/incontinence improved
âIL-6/hs-CRP; âTAC
Immune support improved
Mo/Cd damage
Cu boosts antibodies
Mixed immune markers
Non-monotonic dose response
Anti-inflammatory IL-10 +2.2
Glucose control -5.8
Mood maintained; inflammation â
BDNF â dose-dependent
Lower inflammation markers
Fibrinogen down
âTNF-α, neopterin
âIFNÎł/IL-4
T-cells +0.24
Bifidobacterium +29%
Immune age -2y
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