Proof.Fit

N-Acetyl Cysteine

17 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Cell health

Antioxidant defense +GSH

Liver/kidney protection -25%

Strong
9,936
Antioxidant

Glutathione+oxidative stress

Ongoing pregnancy +24.2pp

Hepatotoxicity -37.5pp

Strong
8,368
Inflammation

CRP/WBC ↓

TNF-α/IL-6 ↓

MDA/TAC shift

Strong
5,545
Respiratory comfort

Symptom relief, better breathing

Exacerbations down, lung function +10%

Strong
8,402
Detoxification

Liver detox +survival

Kidney protection -CIN

Strong
4,564
Immune support

GSH↑, immune survival

Inflammation↓, outcomes↑

Strong
5,379
Liver support

Survival/Liver function

+25pp

Biomarkers/Enzymes ↓

Strong
3,370
Heart health

↓ ischemia/angina, +14% TIMI

↓ AF/inflammation/oxidative stress

Strong
2,821
Mucus clearance

sputum viscosity ↓

mucus clearance ↑

+10–40%

Strong
3,615
Brain health

Cognition + memory

Addiction cravings −30%

Inflammation/brain markers

Strong
1,853
Vascular health

Endothelial function, ICAM/VCAM

-25.4% homocysteine, BP

Nitrate tolerance relief

Strong
2,621
Mood balance

Mood: ↓ depressive/anxiety

Mood: ↓ craving/irritability

+80% response

Moderate
953
Healthy aging

Oxidative stress ↓

Frailty/inflammation ↓

Moderate
1,233
Skin health

Skin healing improved

Inflammation/oxidation reduced

Moderate
485
Energy & Fatigue

GSH/mitochondria + fatigue

23.8–26.3% longer

EPO/VO2 preserved

Moderate
172
Exercise recovery

Oxidative stress ↓

Performance +25%

Weak
140
Eye health

Tear stability/immunity +23%

Corneal rescue +21.7%

Weak
133