Vitamin D

↑25OHD ↓PTH

↑BMD ↓resorption

Muscle + vitamin D

Bone/falls + vitamin D

Bone/metabolic: +25(OH)D

Mood/immune: fewer symptoms

Safety: no hypercalcaemia

Immune↑ Tregs

Inflammation↓ IL-6

infection↓ 44%

↑25(OH)D, ↓PTH

↑Ca absorption, ↓PTH

Lobular inflammation ↓

CRP/IL-6 ↓

Psoriasis control; +70% PASI

Vitiligo repigmentation; +35%

Wound healing; -88%

Maternal+cord 25OHD

↑24.6 nmol/L; +48pp

Infant growth/bone

Respiratory infections ↓

Asthma/COPD control ↑

BP/endothelium

-7.5 mmHg

Lipids/inflammation

Pain recovery −22%

Muscle strength +0.95

Infection recovery +44%

Fat loss +weight

Glucose/insulin ↓

Falls/balance improved

Neuropathy risk lower

Strength/mass +25(OH)D

Falls/function ↓; +25(OH)D

Cognition + memory

+1.95 points

MS/PD lesion control

Mood: depression↓

Anxiety/irritability↓ +10%

Cognition/wellbeing↑ +30%

Fatigue ↓ +10

Fitness better

Tooth loss ↓52%

Gingivitis, healing, bone

Sleep quality +1.7 PSQI

Sleep timing variability

Sleep duration +