Proof.Fit

L-Methionine

17 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Cell health
Strong

Choline depletion ↑ALT

Homocysteine ↓ with supplements

13,042 people
Liver support
Strong

ALT/cholestasis ↓

Fibrosis risk ↓

Liver prediction +0.06

3,405 people
Detoxification
Strong

GSH/Cysteine detoxification

Homocysteine lowering

4,232 people
Metabolism
Strong

Lipids ↑ with methionine

Homocysteine ↑; vessel function ↓

Methionine restriction: fat loss

6,079 people
Muscle growth
Strong

Muscle protein synthesis +

Growth + weight gain

Amino acids + methionine

6,484 people
Antioxidant
Strong

Glutathione↑, MDA↓

Selenium/antioxidants↑

2,135 people
Healthy aging
Strong

Homocysteine↓, risk↓

Methylation↑, aging↓

3,201 people
Brain health
Moderate

Memory/executive +0.84

+ methylation/choline

Depression response +18.5%

1,624 people
Mood balance
Moderate

Depression ↓; remiss. +18.5pp

Mood stable; biomarkers ↑500%

Male benefit d=0.95

1,598 people
Immune support
Moderate

Leukocyte/antibody boosts

−55% anti‑TPO

−34pp mucositis

1,515 people
Nutrition source
Moderate

Met boost; AA markers

Cys spares Met need

1,765 people
Hormone balance
Moderate

Immune ↓; TgAb −

Inflammation ↓; Steroidogenesis ↑

2,696 people
Digestive support
Moderate

Digestive diges.+VFA

Symptoms/ulcer relapse

Mucositis -24%

1,777 people
Joint comfort
Moderate

Pain relief similar vs NSAIDs

Tenderness down; liver enzymes +

336 people
Energy & Fatigue
Moderate

Methionine: DMI, milk, protein

Fatigue: cycling +1.4 min

346 people
Skin appearance
Weak

Faster healing, fewer relapses

Lesion scores down

Ulcer healing +23pp

294 people
Hair & Nails
Weak

Hair outcomes +1.01

Wool traits, methionine

83 people