Proof.Fit

Berberine

16 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Metabolism

Lipids/Glucose ↓

Liver fat/ALT ↓

Insulin resistance ↓

Strong
3,504
Cholesterol

LDL/TC −

TG/HDL +

Strong
2,799
Blood sugar

Lower glucose/HbA1c

Lower insulin resistance

Strong
2,524
Heart health

LDL/TC ↓

Inflammation/arterial function ↓

Strong
2,622
Inflammation

Inflammation ↓; CRP/IL-6

Inflammation ↓; 35%→20%

Fibroinflammation ↓; ALT −4.8%

Strong
1,336
Gut health

H. pylori: +50%

Diarrhea: -30%

Strong
2,577
Cell health

Liver fat/enzymes −5%

Glucose/lipids −1%

Strong
2,536
Weight management

Weight loss, fat -3.5kg

Glycemia/lipids, less weight

Fat loss, waist/BMI

Moderate
1,238
Digestive support

H. pylori/ulcer: +clearance

Diarrhoea/IBS: -30% stools

Adenoma recurrence: -11%

Moderate
3,404
Liver support

Liver fat, ALT −5

Lipids/insulin, liver support

ALP/cholestasis, liver enzymes

Moderate
955
Hormone balance

Androgen↓, SHBG↑

Insulin resistance↓

Moderate
1,082
Healthy aging

Lipids/IR −31%

Adenoma recurrence −11%

Heart function, fewer deaths

Moderate
1,894
Immune support

Reduced inflammation

Immune marker gains

Moderate
663
Skin health

Pain/inflammation ↓

Ulcers healed faster

Healing score, pain ↓

Weak
150
Energy & Fatigue

↑ LVEF, walk capacity

↓ VPCs; 7 vs 13 deaths

Weak
156
Blood pressure

BP −8 mmHg

Aortic BP −10.4

Weak
70