Proof.Fit

Berberine

16 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Lipids/Glucose ↓

Liver fat/ALT ↓

Insulin resistance ↓

3,504 people

LDL/TC −

TG/HDL +

2,799 people

Lower glucose/HbA1c

Lower insulin resistance

2,524 people

LDL/TC ↓

Inflammation/arterial function ↓

2,622 people

Inflammation ↓; CRP/IL-6

Inflammation ↓; 35%→20%

Fibroinflammation ↓; ALT −4.8%

1,336 people

H. pylori: +50%

Diarrhea: -30%

2,577 people

Liver fat/enzymes −5%

Glucose/lipids −1%

2,536 people

Weight loss, fat -3.5kg

Glycemia/lipids, less weight

Fat loss, waist/BMI

1,238 people

H. pylori/ulcer: +clearance

Diarrhoea/IBS: -30% stools

Adenoma recurrence: -11%

3,404 people

Liver fat, ALT −5

Lipids/insulin, liver support

ALP/cholestasis, liver enzymes

955 people

Androgen↓, SHBG↑

Insulin resistance↓

1,082 people

Lipids/IR −31%

Adenoma recurrence −11%

Heart function, fewer deaths

1,894 people

Reduced inflammation

Immune marker gains

663 people

Pain/inflammation ↓

Ulcers healed faster

Healing score, pain ↓

150 people

↑ LVEF, walk capacity

↓ VPCs; 7 vs 13 deaths

156 people

BP −8 mmHg

Aortic BP −10.4

70 people