Spermidine

11 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Moderate

Hair growth ↑

AK lesions −24%

Skin polyamines ↓

590 people

Moderate

Polyamines up in gut

Transit/function changes

Colorectal risk biomarker shift

597 people

Moderate

vascular/cognitive +

antioxidant/autophagy +

229 people

Moderate

Autophagy/BDNF +7–13%

Detox markers −21–27%

490 people

Moderate

Brain + memory

Autophagy + inflammation

233 people

Weak

Endothelial function +0.31

Nitric oxide, spermidine

364 people

Vascular health

Weak

Endothelium +RHI 0.31

Nitric oxide, spermidine

364 people

Focus & concentration

Weak

Cognition +6.25

Memory +0.17

115 people

Weak

Memory +0.17

Cognitive score +6.25

BDNF +12.1%

115 people

Weak

Anti-inflammatory −21% CRP

Oxidative defense +Nrf2

80 people

Weak

Lower TNF-α/ROS

CRP −20.8%

80 people

Main Effects

Hair growth ↑

AK lesions −24%

Skin polyamines ↓

Moderate

590

Polyamines up in gut

Transit/function changes

Colorectal risk biomarker shift

Moderate

597

vascular/cognitive +

antioxidant/autophagy +

Moderate

229

Autophagy/BDNF +7–13%

Detox markers −21–27%

Moderate

490

Brain + memory

Autophagy + inflammation

Moderate

233

Endothelial function +0.31

Nitric oxide, spermidine

Weak

364

Vascular health

Endothelium +RHI 0.31

Nitric oxide, spermidine

Weak

364

Focus & concentration

Cognition +6.25

Memory +0.17

Weak

115

Memory +0.17

Cognitive score +6.25

BDNF +12.1%

Weak

115

Anti-inflammatory −21% CRP

Oxidative defense +Nrf2

Weak

80

Lower TNF-α/ROS

CRP −20.8%

Weak

80