Proof.Fit

Vitamin B9

14 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Heart health

Homocysteine ↓, cardiac risk

Vascular function ↑, Hcy ↓

Strong
528,161
Pregnancy support

Pregnancy support: NTD/birthweight↓

Counseling: folate use↑ +26.5pp

Strong
336,594
Nutrition source

Folate status↑, Hcy↓

Anemia/toxicity↓, Hb↑

Strong
125,429
Brain health

Cognition + homocysteine

~30% tHcy drop

Brain atrophy −40%

Strong
933,820
Cell health

Lower liver/blood toxicity

Higher folate biomarker levels

Better cancer control

Strong
99,634
Mood balance

Mood: −2.65 HDRS

Mood: relapse −52%

Strong
869,827
Energy & Fatigue

Hb↑, fatigue↓

Anaemia↓, Hb↑

Strong
53,924
Healthy aging

Brain/cognition protection

Homocysteine↓, folate↑

Strong
53,587
Focus & concentration

Processing speed +8.8

Memory/attention + small gains

Strong
12,721
Nerve health

Nerve symptoms, homocysteine

+30% homocysteine drop

Nerve conduction improves

Strong
25,542
Detoxification

Arsenic detox: +DMAs -InAs

Homocysteine detox: -30%

Liver enzymes: -0.6 IU/L

Strong
10,686
Immune support

Fewer infections, shorter illness

Lower inflammation, better immunity

Strong
8,459
Appetite regulation

↓ Insulin/hunger peak

+1.7 appetite score

↑ reported appetite/energy

Weak
161
Hair & Nails

Hemoglobin ↑

Memory/attention ↑

Weak
129