Fumaric Acid

7 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Skin appearance

Moderate

Psoriasis improvement

GI/flushing side effects

2,074 people

Moderate

Psoriasis improvement +50%

GI side effects common

PASI-76% with calcipotriol

2,074 people

Moderate

Skin improvement, ~50%

T-cell shift, no morphology

DLQI -5.9, PASI75 37.5%

1,641 people

Moderate

Skin clearance +76%

QoL improved +46%

Lower FAE dose -24%

1,043 people

Weak

Improved mood, DLQI −5.9

Better life impact, +36%

Skin benefit, GI AEs

805 people

Weak

Gut bacteria+constipation

Diarrhoea↓, growth↑

SCFA↓, harmful E. coli↓

480 people

Weak

Cholesterol/ApoB down

FMD unchanged

65 people

Main Effects

Skin appearance

Psoriasis improvement

GI/flushing side effects

Moderate

2,074

Psoriasis improvement +50%

GI side effects common

PASI-76% with calcipotriol

Moderate

2,074

Skin improvement, ~50%

T-cell shift, no morphology

DLQI -5.9, PASI75 37.5%

Moderate

1,641

Skin clearance +76%

QoL improved +46%

Lower FAE dose -24%

Moderate

1,043

Improved mood, DLQI −5.9

Better life impact, +36%

Skin benefit, GI AEs

Weak

805

Gut bacteria+constipation

Diarrhoea↓, growth↑

SCFA↓, harmful E. coli↓

Weak

480

Cholesterol/ApoB down

FMD unchanged

Weak

65