Proof.Fit

Isoleucine

13 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Metabolism
Strong

Glucose/insulin: -14%

BCAA/isoleucine: ↓

BP: -4 mmHg

2,409 people
Protein source
Moderate

BCAA rises, protein gain

1. Isoleucine up

2. Weight/anabolism up

642 people
Vitality
Moderate

BCAAs, growth

BCAAs, survival

741 people
Weight management
Moderate

↓BCAAs, ↑weight loss

↓hunger, ↓intake

↑satiety hormones

1,304 people
Body composition
Moderate

Leaner tissue, +0.4 kg

Protein balance, +38 mg N/kg/d

423 people
Muscle growth
Moderate

MPS/anabolism +3.5x

Lean mass/growth +1.0%

355 people
Nutrition source
Moderate

Nitrogen balance +38.3

Plasma isoleucine + BCAA

454 people
Blood sugar
Moderate

↓ glucose AUC

↑ insulin/GLP-1

−14% glucose AUC

1,284 people
Immune support
Moderate

Immune markers +10%

Immune suppression -5

363 people
Tissue repair
Moderate

Protein repair +

Damage markers -

274 people
Muscle maintenance
Moderate

Protein balance +38.3

Muscle breakdown ↓

227 people
Appetite regulation
Weak

Amino acids ↓ hunger

Amino acids ↓ intake

Amino acids ↑ satiety

106 people
Exercise recovery
Weak

Less muscle damage

Faster strength recovery

Higher protein synthesis

40 people