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S-Adenosyl Methionine

14 benefits mapped to clinical evidence across supplements.

Serves the goals:Bone & JointCognitionDetoxEnergyImmune Support

Benefit Evidence

Pain relief
Moderate

Itching, liver tests

Pain relief, similar by 8w

941 people
Mood balance
Moderate

Depression severity, response/remission

-18.5pp response; +14.1pp remission

Earlier mood improvement

1,448 people
Liver support
Moderate

Cholestasis markers, itch

Liver protection, survival

1,058 people
Detoxification
Moderate

Glutathione ↑; MDA ↓

SAM/SAH ↑; tHcy ↔

1,057 people
Vitality
Moderate

Homocysteine/SAM balance

Liver outcomes & survival

543 people
Metabolism
Moderate

SAM/methylation preserved

Homocysteine shifted

785 people
Focus & concentration
Moderate

SAM↑, cognition↑

DAT↕, no insulin

461 people
Memory
Moderate

SAM↑, Hcy↓

Aβ↓, cognition↑

461 people
Mental clarity
Weak

SAM ↑, cognition ↑

DAT/metabolites shift

301 people
Joint comfort
Weak

Pain eased similarly

Function improved; fewer AEs

Month 1: +9.3, +11.6

195 people
Joint mobility
Weak

Pain/function ~equal

+9 to +12 pain

Fewer adverse events

195 people
Energy & Fatigue
Weak

Fatigue/pruritus better

Bilirubin/AP ↓

220 people
Illness recovery
Weak

Lower endotoxin/inflammation

+21.57% response

102 people
Immune support
Weak

Endotoxin/MMP-9/IL-18 ↓

Response rate +21.6%

102 people

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Curcumin

Shares 10 benefits: energy & fatigue, focus & concentration, illness recovery, immune support

Panax Ginseng

Shares 9 benefits: energy & fatigue, focus & concentration, illness recovery, immune support

Alpha-Lipoic Acid

Shares 8 benefits: detoxification, energy & fatigue, immune support, joint comfort

Ornithine

Shares 8 benefits: detoxification, energy & fatigue, illness recovery, immune support

Thiamine

Shares 8 benefits: energy & fatigue, focus & concentration, illness recovery, memory

Niacin

Shares 8 benefits: detoxification, energy & fatigue, immune support, joint comfort

Products with S-Adenosyl Methionine

Search all

12 products whose verified label declares S-Adenosyl Methionine — not every bottle that mentions it in a title.

Dr. Berg Nutritionals

Dr. Berg Liver Cleanse Detox Capsules w/Unique Blend of Milk Thistle

Folate 260 mcg DFE ¡ Choline 100 mg ¡ Proprietary Blend 537 mg +7 more

$23.99Milk Thistle

Nature's Trove

Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60)

S-Adenosyl-Methionine 400 mg

$57.98Blended Vitamin & Mineral Supplements

Neurobiologix

Neurobiologix Full Focus, Brain & Mood Support Supplement, 90 Capsules

Niacin 400 mg ¡ Niacinamide 200 mg ¡ Inositol Hexanicotinate 200 mg +9 more

$45.95Green Coffee Bean Extract

Swanson Ultra

Swanson High-Potency Same 400 Milligrams, 30 Tablets

SAMe 400 mg ¡ S-Adenosyl-L-Methionine Tosylate Disulfate 800 mg

$30.99Blended Vitamin & Mineral Supplements

Natrol

Natrol SAMe Mood Support Tablet, 400 Mg

S-Adenosyl-Methionine 400 mg

Herbal Supplements

Natrol

Natrol Sam-E 400mg

S-Adenosyl-Methionine 400 mg

$24.61Green Tea

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.

Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.S-Adenosyl Methionine ¡ Hyperhomocysteinemia ¡ 111 participants planned ¡ ClinicalTrials.govRecruiting