Proof.Fit

Docosahexaenoic Acid

20 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Cholesterol

TG↓, LDL↑

O3I↑, TG↓

HDL↑, LDL↑

Strong
46,973
Heart health

Triglycerides, BP -5 mmHg

AF recurrence 38.5% vs 77.5%

Vascular function, plaque slower

Strong
71,440
Growth support

DHA status growth +

vision/neurodevelopment +

Strong
30,355
Inflammation

Inflammation↓ CRP/IL-6

Inflammation↓ TNF-α/IL-6

Inflammation↓ CRP -15%

Strong
12,654
Eye health

AMD risk ↓

Visual acuity ↑

Strong
56,862
Brain health

Brain networks +0.015

+4 IQ / +7 MDI

Memory/attention + DHA

Strong
18,779
Immune support

Lower inflammation, more n‑3

Immune function shifts

Strong
12,766
Memory

Memory +0.2

Memory +7

Memory +3.5

Strong
11,697
Blood circulation

Improved dilation, flow

+31%, -26%

Lower constriction, clotting

Strong
7,492
Healthy aging

Cardio-protection, −10% events

Brain/aging support, cognition

Strong
6,890
Mood balance

Depression↓ 10-20%

Anxiety/aggression↓ ~5-10%

Strong
4,340
Focus & concentration

Focused attention + faster processing

+3.5 IQ, -6.9 BPD

Better attention, memory

Strong
5,650
Blood pressure

BP ↓ 3-6 mmHg

DHA stronger ↓ BP

SBP/DBP ↓, HR ↓

Strong
3,411
Stress resilience

↓NE, stress

↓anxiety/cortisol

↑HRV, ↓MAP

Strong
1,630
Liver support

Steatosis −53%, ALT

Triglycerides, insulin sensitivity

Liver enzymes ↓

Strong
1,349
Joint comfort

Joint comfort +RA

Pain/stiffness −5 to −10

Moderate
1,179
Energy & Fatigue

fatigue ↓, +74%

physical function ↑, +11%

Moderate
839
Sleep quality

Duration↓wakings↑58min

Efficiency↑latency↓1.7pp

PSQI↑cortisol↓

Moderate
1,376
Bone health

↑n-3, ↓resorption

↑Ca retention, ↑BMD

Moderate
180
Skin hydration

Hydration indirect, severity −11.2

Inflammatory shift, >10-fold

Weak
83