Artemisinin

Efficacy: +95% cure

PK/safety: exposure changes

Transmission: -50% gametocytes

cure +99%

parasites fast-clear

anemia ↓

Parasite clearance +ACPR

Hb/anaemia recovery

HIV/CD4: +2.24 risk

Less malaria/anemia: −69%

Immune cells/cytokines: faster clearance

Liver safety stable

Cell counts recover

Anemia reduced

Malaria↓ anemia↓

+0.6 g/dL Hb

Lower TNF/IL-6

Faster clearance, +1.3%

Clearance faster; cognition unchanged

Negatives improved; cognition unchanged

CYP3A/CYP2C19 ↑

CYP1A2 ↓

ARM clearance ↑4x

Acne severity ↓

Itch relief 82%

Cure +18%, less eggs

Mild adverse events

QTc +28 ms

No QTc change