Proof.Fit

Akkermansia muciniphila

14 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Gut health
Strong

Gut barrier/metabolic ↑

Microbes/pH/SCFAs changes

1,489 people
Weight management
Moderate

Weight loss + insulin

Less appetite + fat

859 people
Metabolism
Moderate

Weight/insulin ↓

Lipids/LPS ↓

843 people
Blood sugar
Moderate

A1c↓ glucose↓

Akkermansia↑ endotoxin↓

582 people
Inflammation
Moderate

Inflammation↓ LPS

Cytokines↓ TGF‑β1↑

Akkermansia↑; LPS↓

469 people
Fat burn
Moderate

Fat mass -

Body weight -

Insulin resistance -

193 people
Liver support
Moderate

AST -

Metabolites

181 people
Cholesterol
Moderate

Akkermansia, LDL-C -9.1%

LPS, small LDL

403 people
Energy & Fatigue
Moderate

Fat oxidation + ketones

Muscle strength + VO2max

220 people
Focus & concentration
Moderate

Cognition + A. muciniphila

SCFAs +42% / +38%

HRV, cognition +

217 people
Appetite suppression
Moderate

Akkermansia/OEA: appetite -

OEA yogurt: appetite -

208 people
Digestive support
Weak

Akkermansia +19.3

Bowel symptoms +2.2/week

143 people
Immune support
Weak

Immune markers ↓, +50% TGF-β1

MDRO/AMR burden ↓, A. muciniphila

Symptoms improved, no safety issues

206 people
Healthy aging
Weak

Leg strength +follistatin

Myostatin unchanged

100 people