Proof.Fit

Arachidonic Acid

19 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Cell health

AA↔EPA/DHA shift

Cell defense/function +20%

Oxidative stress ↓

Strong
22,895
Inflammation

↓AA eicosanoids

↓platelet aggregation

↑EPA/AA ratio

Strong
14,565
Blood circulation

↓AA-platelets

↑EPA/AA,↓TxB2

Strong
11,903
Brain health

AA/DHA boosts brain growth

+7 MDI; visual gains

AA/DHA balance matters

Strong
9,880
Metabolism

AA↓/EPA↑ lipids

TG↓ HDL↑

Strong
27,579
Immune support

Lower LTB4/LTE4

AA→EPA/DHA shift

Immune support +14%

Strong
5,608
Eye health

Eye health: better vision

ROP ↓ 16-17%

Strong
4,232
Memory

Brain/vision, +7

Memory/attention, +5.4

Strong
3,732
Nerve health

vasospasm/infarction ↓

brain/vision development ↑

AA/DHA blood ↑

Strong
3,448
Muscle growth

Muscle genes up

MPS no change

Moderate
979
Mood balance

Improved mood, -17 GDS

AA/EPA shift, mood boost

Moderate
620
Hormone balance

AA/Oxylipins ↑; PTB risk

Hormones/stress: cortisol ↓

Moderate
625
Skin repair

↓ platelet activation

↑ repair markers

Moderate
305
Skin health

Inflammation ↓, +30%

Skin symptoms ↓

AA-mediated irritation ↓

Moderate
373
Exercise recovery

Lower inflammation, faster recovery

-CK, faster immune rebound

Moderate
184
Joint comfort

Anti-inflammatory fatty acids

Joint pain/stiffness ↓

AA:EPA -1.9 pp

Moderate
175
Energy & Fatigue

Intake↑; AA↑ (+25%)

Taste↑; AA↑ (+50%)

Weak
67
Workout performance

DHA↑, AA↓; speed +3%

Walking speed +3%

Weak
118
Strength

PG signaling ↑

IL-6/MuRF-1 ↓

Weak
36