Proof.Fit

Alpha-Linolenic Acid

19 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Cholesterol

LDL/TC down

HDL/TG improved

Ratios improved

Strong
455,908
Heart health

Lipids ↓, BP ↓

Events ↓, death ↓

Inflammation ↓, vessels ↑

Strong
487,376
Blood circulation

Lower clotting, events

Lower lipids, BP

Strong
468,261
Metabolism

ALA↑ EPA↑

DHA↓ glucose↓

Weight↓ lipids↓

Strong
472,594
Inflammation

Inflammation ↓ CRP/cytokines

Inflammation ↓ leukotrienes/prostaglandins

Inflammation ↓ gene expression

Strong
2,717
Cell health

ALA ↑; EPA ↑

Inflammation ↓; SBP ↓6.3

LDL ALA ↑89%

Strong
1,505
Pregnancy support

Higher ALA/DHA status

~+10% pregnancy growth

Strong
3,625
Healthy aging

Heart protection: -73% events

Metabolic/inflammatory aging: better lipids

Strong
10,533
Brain health

DHA/omega-3 status

Cognition/motor gains

Less migraine/MS risk

Strong
3,774
Immune support

Gut barrier/endotoxin ↓

Inflammation markers ↓

Strong
1,743
Mood balance

Mood better, impulsivity lower

Anxiety/migraine improved

Postpartum depression lower

Moderate
615
Blood pressure

SBP/DBP ↓ 10/7 mmHg

DBP ↓ 4 mmHg

Moderate
613
Eye health

Better visual acuity

Rod function preserved

Moderate
546
Liver support

Liver fat ↓

Enzymes/inflammation mixed

CAP/TE ↓

Moderate
273
Hormone balance

Leptin -4.70 ng/mL

Insulin/testosterone down

Insulin resistance down

Moderate
183
Bone health

Bone resorption ↓15%

Bone resorption ↓17%

Bone index ↑

Weak
86
Joint comfort

Bone turnover -15%

Pain scores improved

Weak
100
Energy & Fatigue

Fat oxidation ↑

ALA-DAG +17%

Weak
66
Skin health

Hydration ↑, TEWL ↓

Dryness/itch ↓, meds ↓

Weak
58