Proof.Fit

L-Serine

17 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Protein source

Serine ↑ amino acids

Serine ↓ digestibility

Serine ↔/↓ disease

Strong
35,131
Metabolism

Serine/glycine metabolism

Lipid/BCAA shifts

Strong
7,026
Brain health

Brain function +29%

Neurotransmitters/EEG changes

Moderate
774
Energy & Fatigue

Fatigue -4.4 VAS

Serine↑ / BCAA↓

Hunger↓, GLP-1↑

Moderate
4,108
Mental clarity

Cognitive recovery +29%

Auditory plasticity/MMN +7-14%

Moderate
672
Memory

Memory consolidation +

Learning/memory +

Moderate
629
Healthy aging

Serine methylation, longevity

Cognition/heart risk, improved

Moderate
4,589
Mood balance

Mood ↑ serine/DCS

Depression −4.4 / −34%

Neg symptoms −30%

Moderate
655
Illness recovery

Recovery time −29–38%

Inflammation ↓, serine ↑

Moderate
887
Learning

Learning+extinction: better

Learning+consolidation: better

Moderate
499
Stress resilience

Cortisol block: +4.9 ng/mL

DCS anxiolysis: 71% vs 25%

Moderate
286
Immune support

Amino acids + serine

Immune markers +29%

Moderate
577
Focus & concentration

Motivation/attention + recovery

+1.1% WM consolidation

Moderate
212
Nerve health

Neuropathy: -1.5 score

1-deoxySL: -41% / -60%

Pain: -43% worst pain

Moderate
272
Cell health

Protein synthesis +46%

Methylation/homocysteine

Auditory/symptom improvement

Weak
90
Sleep quality

Faster sleep onset; +24 min

Longer, better sleep; +22 min

Weak
106
Muscle maintenance

Amino acids + weight

Serine preservation, synthesis

Lean mass gains

Weak
40