Proof.Fit

L-Serine

17 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Protein source
Strong

Serine ↑ amino acids

Serine ↓ digestibility

Serine ↔/↓ disease

35,131 people
Metabolism
Strong

Serine/glycine metabolism

Lipid/BCAA shifts

7,026 people
Brain health
Moderate

Brain function +29%

Neurotransmitters/EEG changes

774 people
Energy & Fatigue
Moderate

Fatigue -4.4 VAS

Serine↑ / BCAA↓

Hunger↓, GLP-1↑

4,108 people
Mental clarity
Moderate

Cognitive recovery +29%

Auditory plasticity/MMN +7-14%

672 people
Memory
Moderate

Memory consolidation +

Learning/memory +

629 people
Healthy aging
Moderate

Serine methylation, longevity

Cognition/heart risk, improved

4,589 people
Mood balance
Moderate

Mood ↑ serine/DCS

Depression −4.4 / −34%

Neg symptoms −30%

655 people
Illness recovery
Moderate

Recovery time −29–38%

Inflammation ↓, serine ↑

887 people
Learning
Moderate

Learning+extinction: better

Learning+consolidation: better

499 people
Stress resilience
Moderate

Cortisol block: +4.9 ng/mL

DCS anxiolysis: 71% vs 25%

286 people
Immune support
Moderate

Amino acids + serine

Immune markers +29%

577 people
Focus & concentration
Moderate

Motivation/attention + recovery

+1.1% WM consolidation

212 people
Nerve health
Moderate

Neuropathy: -1.5 score

1-deoxySL: -41% / -60%

Pain: -43% worst pain

272 people
Cell health
Weak

Protein synthesis +46%

Methylation/homocysteine

Auditory/symptom improvement

90 people
Sleep quality
Weak

Faster sleep onset; +24 min

Longer, better sleep; +22 min

106 people
Muscle maintenance
Weak

Amino acids + weight

Serine preservation, synthesis

Lean mass gains

40 people