proof.fit

Niacin

20 benefits mapped to clinical evidence across supplements.

Benefit Evidence

LDL↓ HDL↑

TG↓ +39%

HDL +11–23 mg/dl

Cholesterol ↓ (lipids)

75,749 people

HDL↑ LDL↓ events↓

IMT↓ 0.01mm

14,867 people

HDL↑ TG↓ LDL↓

Glucose↑ insulin resistance↓

18,249 people

HDL↑ LDL↓

CIMT/FMD +22%

Blood flow↑

Exercise +1.5 min

Blood flow/flow reserve

MACE -2.4%

16,185 people

Barrier +25%/−20%

Flushing −50%

Itch −28%

Pigment/texture +MASI

Barrier/hydration -TEWL

5,686 people

Cognition, global status improved

SCAG/CGI improved significantly

Cognitive/neurologic improvement

Nerve protection, -2.65 TSS

2,815 people

Improved dementia ratings

Boosted blood flow

Cognition/neurology improved

Ischemia reduced ~25%

NAD+ up, symptoms down

2,602 people

NAD+ boost; cell stress

Inflammation/oxidative stress reduced

Cancer/skin control improved

3,030 people

Cognitive recovery +14%

Stroke lesions -25%

Postop confusion -50%

1,659 people

Atherosclerosis slowed

HDL/LDL improved

NAD+ metabolism: +139%

Skin aging, wrinkles, spots

5,948 people

Fuel shift: FFA↓, carbs↑

NAD+ boost: ~2x

NAD+↑, fatigue↓

Exercise tolerance↑, fatigue↓

1,778 people
Blood sugar
Moderate

Early insulin +100%

Glucose iAUC -61%

Diabetes incidence -41%

438 people

HDL up, CRP -15%

Triglycerides -15%, Lp-PLA2 -20%

UV immune protection

↓ IL-8, ↑NAD+

278 people

ALT/GGT down, fat no change

Responders +6.1%; GGT/ALP down

428 people

↓ flushing, GI AEs

no serious-AE rise

Phosphorus/PTH drop

Ca×P decline

11,370 people

Recurrent MI ↓

15-year mortality ↓14%

3,906 people

Stress system optimized

Stress resistance improved

266 people

Phosphorus -0.7 to -1.0

Albumin improved

98 people

Less arthritis impact, +29%

Better mobility, +4.5°

72 people

Leptin +2.38; FFA ↓

Leptin +26.8%; HOMA +42%

↑ appetite, +weight

+B3, +B12,D

70 people

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Niacin

Search all

785 products whose verified label declares Niacin — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.