Proof.Fit

Piperine

18 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Metabolism

Lipids/glucose ↓

Weight/IR ↓

Moderate
967
Inflammation

CRP/TNF-α ↓

PGE2 ↓

Moderate
769
Blood sugar

Fasting glucose ↓ ~9-12

HbA1c ↓ ~0.3-0.8%

Moderate
638
Liver support

ALT/NAFLD ↓

Enzymes ↓ 35.8

ALP/NAFLD ↓

Moderate
645
Heart health

Lipids/glucose ↓; HDL ↑

LDL -18 mg/dL

Moderate
496
Antioxidant

↓MDA/↑GSH

↑SOD/↓CRP

Moderate
392
Respiratory comfort

Improved breathing symptoms

Marked PAS reduction

93% vs 84%

Moderate
410
Immune support

Allergy relief, IgE ↓100

Inflammation control, CRP/ESR ↓

Moderate
256
Nutrient uptake

Increased uptake +120%

Reduced ALT -8 U/L

Moderate
366
Weight management

Weight loss +5.85 kg

Weight maintenance +30%

Moderate
223
Detoxification

Liver detox +10

Metabolic detox markers

Weak
288
Skin health

Vitiligo repigmentation + irritation

Hair regrowth, SALT ↓

Weak
123
Mood balance

Stress/anxiety ↓ -9.4

Depression/anxiety ↓ +serotonin

Weak
120
Joint comfort

PGE2, pain improved

IL-4, IL-6, hs-CRP down

Weak
100
Pain relief

PGE2↓; pain relief

Inflammation↓, unclear pain

Weak
100
Antimicrobial

Sputum conversion +9%

Cure rate +10%

Liver enzymes -6

Weak
216
Healthy aging

Muscle mass +

Cell health +

Weak
58
Digestive support

Safer swallows −57%

Faster closure 0.380→0.306s

Weak
40