Proof.Fit

Piperine

18 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Metabolism
Moderate

Lipids/glucose ↓

Weight/IR ↓

967 people
Inflammation
Moderate

CRP/TNF-α ↓

PGE2 ↓

769 people
Blood sugar
Moderate

Fasting glucose ↓ ~9-12

HbA1c ↓ ~0.3-0.8%

638 people

ALT/NAFLD ↓

Enzymes ↓ 35.8

ALP/NAFLD ↓

645 people
Heart health
Moderate

Lipids/glucose ↓; HDL ↑

LDL -18 mg/dL

496 people
Antioxidant
Moderate

↓MDA/↑GSH

↑SOD/↓CRP

392 people

Improved breathing symptoms

Marked PAS reduction

93% vs 84%

410 people

Allergy relief, IgE ↓100

Inflammation control, CRP/ESR ↓

256 people

Increased uptake +120%

Reduced ALT -8 U/L

366 people

Weight loss +5.85 kg

Weight maintenance +30%

223 people

Liver detox +10

Metabolic detox markers

288 people

Vitiligo repigmentation + irritation

Hair regrowth, SALT ↓

123 people

Stress/anxiety ↓ -9.4

Depression/anxiety ↓ +serotonin

120 people

PGE2, pain improved

IL-4, IL-6, hs-CRP down

100 people

PGE2↓; pain relief

Inflammation↓, unclear pain

100 people

Sputum conversion +9%

Cure rate +10%

Liver enzymes -6

216 people

Muscle mass +

Cell health +

58 people

Safer swallows −57%

Faster closure 0.380→0.306s

40 people