Heart health
135 supplements analyzed and ranked by clinical evidence.
Supplement Evidence
Triglycerides ↓; heart events
Plaque/BP/vascular function
Homocysteine ↓, cardiac risk
Vascular function ↑, Hcy ↓
Lipids↓ TG,LDL
Arrhythmia/Death↓ AF,MACE
K↓ arrhythmia risk
K↑ arrhythmia risk
LDL/TC↓ 8-14%
BP↓ 6-10 mmHg
Lower homocysteine
Better vessel function
Lower stroke risk
LDL↓, HDL↑
Vessel function↑, oxidation↓
BP↓, events↓
Triglycerides, BP -5 mmHg
AF recurrence 38.5% vs 77.5%
Vascular function, plaque slower
Arrhythmia prevention
-23 p.p. AF
Blood pressure lower
BP/endothelium
-7.5 mmHg
Lipids/inflammation
Better heart calcification
Warfarin INR control
Lipids ↓, BP ↓
Events ↓, death ↓
Inflammation ↓, vessels ↑
Heart rhythm/QT improved
BP/AF changes with calcium
Hcy↓, vessel function↑
Hcy↓, plaque/events↓
LDL/TC ↓ 7–23%
ApoB/oxidized LDL ↓
TG/HDL markers ↓
LDL↓, TG−16.6%
Heart injury↓, stays−1d
Vasodilation↑, BP↓
HDL↑ LDL↓ events↓
IMT↓ 0.01mm
Cardio mortality -49%
Heart function, biomarkers
Cholesterol reduced ~12%
Innervation +7% vs -14%
Exercise/ischaemia +45s, +25%
Mortality -11.3%
Lower TMAO/homocysteine
Better vessel function
Fewer MI/stroke
Heart injury/function: ↓ injury
Rhythm/autonomic: ↓ arrhythmias
Pump function, fewer events
BP, inflammation, oxidative stress
Blood pressure, lipids
Platelets, plaques
LDL/TC ↓, BP ↓
Endothelial function ↑
Inflammation/oxidation ↓
Lipid lowering, HDL↑
Plaque/heart risk ↓
Lipids/endothelial health
+37% FMD, -58 mg/dL TG
Glucose/BP/inflammation
Angina relief, +25pp
Endothelial/arterial function, -46%
Lower heart injury markers, -26%
Lipids/HDL +7.7–37.5%
Blood pressure/FMD ↓
Inflammation/oxidation ↓
Endothelial function +50%
LDL/BP −12 mmHg
LDL/TC -20-35%
Events/death -30-50%
Function/inflammation improved
Lower BP, fewer events
Homocysteine down, lipids up
↓ ischemia/angina, +14% TIMI
↓ AF/inflammation/oxidative stress
LDL −30%; total −10%
BP −6 mmHg
Lipids: LDL↓ HDL↑
Platelets/BP: less clotting
LDL/TC ↓
Inflammation/arterial function ↓
Lipids/BP ↓
Inflammation/ischemia ↓
Lipids, glucose, BP
MI -16.9%; PWV
Endothelial function + FMD
BP/insulin/inflammation down
LDL ↓ 6-14%
Sterol markers ↑/↓
Lower LDL/TG
Better BP/FMD
Anti-clotting ↑EPA
Lipids down: LDL/TC
Blood pressure/endothelial function up
Arrhythmia/ischemia reduced
Lower BP, stiffness
Event risk −10%
Endothelial dilation +2.4%
Blood pressure -15 mmHg
LVEF up, symptoms better
+4.24% LVEF; biomarkers down
TMAO↑/↓ heart risk
Lipids, BP, restenosis ↓
BP↓ / FMD↑
Arterial stiffness↓ / mPAP↓
Cholesterol/LDL down
Inflammation down
BP/FMD improved
Lower BP, better FMD
Less ischemic death
LDL, HbA1c ↓
BP/HR, CVD risk ↓
Lipids, −20% LDL
Blood pressure, −13.1 mmHg
Oxidative stress, −37.5% CRP
Lipids ↓; heart risk
BP/HRV improved; heart risk
Endothelial/oxidation improved
Homocysteine −24%
CVD risk HR≈2.2
Blood pressure −20 mmHg
Lipids/glucose improved
Lipids↓ TG/LDL
Blood sugar↓ FBG/HbA1c
BP/inflammation↓
Exercise capacity, symptoms
BP/cardiac workload, inflammation
Blood pressure, stiffness
Lipids, glucose, inflammation
BP & lipids improved
Heart function protected
Stool more frequent
Transit faster
Pump function +5.1% LVEF
Lipids/angina ↓; FMD +4.1
Endothelial function +FMD
Blood pressure/lipids ↓
Insulin resistance/lipids ↓
Better glucose control
Lipids/BP down
LDL/TG down
Inflammation/vascular markers improved
LDL/ApoB↓, HDL↑
BP control↑, bleeding↓
Heart risk factors down
TC/LDL/TG lower
+2.8 HDL
Lipids down; HDL up
Inflammation down; vascular up
Lipids/glucose ↓; HDL ↑
LDL -18 mg/dL
Lower LDL/total cholesterol
Better LDL:HDL ratio
LDL/TC ↓ ~10-22%
Triglycerides/BP ↓
Homocysteine ↓ 22-40%
BP ↓ 5-9 mmHg
Lower LDL, BP
HTN risk -34%
Lower TG, LDL
TG/LDL ↓ ~10%
Omega-3 ↑ 2x
Vessels: FMD↑, PWV↓
Lipids/Inflammation: LDL↓, CRP↓
LDL/total cholesterol ↓
Blood vessel function ↑
Triglycerides/insulin ↓
Endothelial health, +41%
Blood pressure, -7.5
Arterial compliance +23%
LDL/HDL improved
Blood pressure -8/-4
Lipids/oxidative stress
Glucose/endothelial
Vessel function: +28.4% FMD
Blood pressure: -6.9 mmHg
EF +7-8%
Inflammation -59%
Pump function +5.3%
Diuresis, injury↓
Better heart pump
↓ inflammation, BP
Heart function +3.9%
Cardiac injury -61.5%
Stiffer arteries -0.34 m/s
Lower CVD risk HR 0.80
Better lipids/BMI
Lipids↓, HDL↑
Inflammation↓
Lipids improve; DBP -4.8 mmHg
Cholesterol, triglycerides, HDL/ApoB
Cholesterol −4.7 to −6.4%
Systolic BP −5 mmHg
Lipid lowering
Platelet/endothelial support
Endothelial function, BP -6
Inflammation/lipids, FMD +28%
Lipids ↓; FMD ↑
BP/stiffness ↓; eNOS ↑
Blood pressure ↓ 8.8
Atherogenic lipids ↓ 18%
Vascular/inflammation +21%
Lipids/cholesterol -23%
Inflammation/enzymes -19%
LDL down ~10%
HDL up, glucose down
Small LDL reduced
Blood pressure ↓
Endothelial function ↑
Vessel function +1.6%
Lower CVD risk 52%
VAT loss −14.1%
Lower BP, TG
Less stiffness, IL-8
BP -7.6 mmHg
LDL/triglycerides down
Blood pressure -10/6
Lipids/glucose/inflammation lower
Arteries/events improved
Endothelial function +0.31
Nitric oxide, spermidine
Omega-3↑; triglycerides↓
HDL↑ 7%; TG↓
Platelet aggregation↓; cholesterol↔
Memory + BP
-7 mmHg SBP
Faster executive response
Weight/waist, HDL↑
Glucose/lipids improved
Clotting slowed; PT/aPTT↑
BP lowered; renin↓ (-5.6/-2.8)
Oxidative stress ↓
Lipids improved −22%
Lipids improved heart markers
HDL/LDL +32%
Cholesterol, TG down
Weight/waist −5.2 kg
Lipids improved; TG −42%
BP ↓; LDL/TC ↓
VO2max, SV/CO ↑
-14% LDL, +10% TC
Heart rate -4%
IL-6 -
LDL -28.3%
Lipids/BMI ↓
SBP -9.2%
Lipids, glucose ↓
Blood pressure ↓
Blood flow +1.4%
HDL +7.7%
BP −8.9/−5.8
HDL/FA profile
Body fat/HDL
BP, LDL -6%
Inflammation, fibrinogen -42%
Cardiac events -4.6%
Kidney function +3.2
BP, TG, CRP -10/-14
LDL, glucose, HbA1c -22%
Lower BP, waist -1.5 cm
Heart strain reduced
↓ lipids, inflammation
↑ HDL, -24% homocysteine
LDL-C down more
TC/HDL-C unchanged
BP ↓; +FMD
+Glucose/waist ↓
HDL↑, SBP↓ 10 mmHg
VAI↓ 0.75
BMI/cholesterol down
HDL up
Blood pressure ↓
Triglycerides ↓ HDL ↑
Triglycerides -14 mg/dL
HbA1c -1.15%
Clot-busting, flow +venous
RBC aggregation, viscosity -
Vascular stiffness, BP
LDL: -8%
Artery plaque, IMT ↓
Inflammation ↓ more than control
Cholesterol/triglycerides -12%
Lipid peroxides -33%
LDL, glucose down
insulin resistance down
Lipids, glucose −23.7%
Inflammation, kidney stability
LAP -8.7; IL-6 rise blunted
Better saliva microbes; heart risk
Autonomic support, +HRV
MIBG preservation, -14% loss
↓Triglycerides −15%
↓LDL, oxidative stress
Triglycerides -15%
LDL/oxidative stress
QTc +28 ms
No QTc change
HDL +0.08 mmol/L
CVD risk -0.8%
vascular age -1.9y
LDL/TC down 9–16%
Post-meal TG down 73%
HDL↑, BP↓
AIx/BP↓