Proof.Fit

Heart health

135 supplements analyzed and ranked by clinical evidence.

Supplements135

Supplement Evidence

Main Effects
Omega-3 Fatty Acids

Triglycerides ↓; heart events

Plaque/BP/vascular function

Strong
288519
Vitamin B9

Homocysteine ↓, cardiac risk

Vascular function ↑, Hcy ↓

Strong
275814
Fish Oil

Lipids↓ TG,LDL

Arrhythmia/Death↓ AF,MACE

Strong
290520
Potassium

K↓ arrhythmia risk

K↑ arrhythmia risk

Strong
319717
Fiber

LDL/TC↓ 8-14%

BP↓ 6-10 mmHg

Strong
364513
Folic Acid

Lower homocysteine

Better vessel function

Lower stroke risk

Strong
274515
Vitamin E

LDL↓, HDL↑

Vessel function↑, oxidation↓

BP↓, events↓

Strong
181517
Docosahexaenoic Acid

Triglycerides, BP -5 mmHg

AF recurrence 38.5% vs 77.5%

Vascular function, plaque slower

Strong
140520
Magnesium

Arrhythmia prevention

-23 p.p. AF

Blood pressure lower

Strong
183419
Vitamin D

BP/endothelium

-7.5 mmHg

Lipids/inflammation

Strong
435919
Vitamin K

Better heart calcification

Warfarin INR control

Strong
66214
Alpha-Linolenic Acid

Lipids ↓, BP ↓

Events ↓, death ↓

Inflammation ↓, vessels ↑

Strong
31119
Calcium

Heart rhythm/QT improved

BP/AF changes with calcium

Strong
877212
Vitamin B12

Hcy↓, vessel function↑

Hcy↓, plaque/events↓

Strong
95115
Phytosterols

LDL/TC ↓ 7–23%

ApoB/oxidized LDL ↓

TG/HDL markers ↓

Strong
30617
Arginine

LDL↓, TG−16.6%

Heart injury↓, stays−1d

Vasodilation↑, BP↓

Strong
125319
Niacin

HDL↑ LDL↓ events↓

IMT↓ 0.01mm

Strong
30813
Selenium

Cardio mortality -49%

Heart function, biomarkers

Cholesterol reduced ~12%

Strong
69617
Carnitine

Innervation +7% vs -14%

Exercise/ischaemia +45s, +25%

Mortality -11.3%

Strong
47518
Vitamin B6

Lower TMAO/homocysteine

Better vessel function

Fewer MI/stroke

Strong
54417
L-Carnitine

Heart injury/function: ↓ injury

Rhythm/autonomic: ↓ arrhythmias

Strong
46519
Coenzyme Q10

Pump function, fewer events

BP, inflammation, oxidative stress

Strong
34817
Garlic

Blood pressure, lipids

Platelets, plaques

Strong
15317
Soy Isoflavones

LDL/TC ↓, BP ↓

Endothelial function ↑

Inflammation/oxidation ↓

Strong
35516
Phosphatidylcholine

Lipid lowering, HDL↑

Plaque/heart risk ↓

Strong
29617
Curcumin

Lipids/endothelial health

+37% FMD, -58 mg/dL TG

Glucose/BP/inflammation

Strong
36418
Danshen

Angina relief, +25pp

Endothelial/arterial function, -46%

Lower heart injury markers, -26%

Strong
12117
Anthocyanins

Lipids/HDL +7.7–37.5%

Blood pressure/FMD ↓

Inflammation/oxidation ↓

Strong
13119
Lycopene

Endothelial function +50%

LDL/BP −12 mmHg

Strong
19618
Red Yeast Rice

LDL/TC -20-35%

Events/death -30-50%

Function/inflammation improved

Strong
6814
Multivitamin

Lower BP, fewer events

Homocysteine down, lipids up

Strong
45018
N-Acetyl Cysteine

↓ ischemia/angina, +14% TIMI

↓ AF/inflammation/oxidative stress

Strong
62317
Psyllium

LDL −30%; total −10%

BP −6 mmHg

Strong
9712
Policosanol

Lipids: LDL↓ HDL↑

Platelets/BP: less clotting

Strong
6512
Berberine

LDL/TC ↓

Inflammation/arterial function ↓

Strong
9916
Pomegranate

Lipids/BP ↓

Inflammation/ischemia ↓

Strong
10416
Turmeric

Lipids, glucose, BP

MI -16.9%; PWV

Strong
19419
Resveratrol

Endothelial function + FMD

BP/insulin/inflammation down

Strong
17619
Beta-Sitosterol

LDL ↓ 6-14%

Sterol markers ↑/↓

Strong
6711
Flaxseed Oil

Lower LDL/TG

Better BP/FMD

Anti-clotting ↑EPA

Strong
11617
Quercetin

Lipids down: LDL/TC

Blood pressure/endothelial function up

Arrhythmia/ischemia reduced

Strong
14219
Cocoa Extract

Lower BP, stiffness

Event risk −10%

Strong
407
L-Citrulline

Endothelial dilation +2.4%

Blood pressure -15 mmHg

Strong
11711
Astragalus

LVEF up, symptoms better

+4.24% LVEF; biomarkers down

Strong
14917
Choline

TMAO↑/↓ heart risk

Lipids, BP, restenosis ↓

Strong
76218
Citrulline

BP↓ / FMD↑

Arterial stiffness↓ / mPAP↓

Moderate
23013
Inulin

Cholesterol/LDL down

Inflammation down

BP/FMD improved

Moderate
29112
Taurine

Lower BP, better FMD

Less ischemic death

Moderate
24013
Chromium

LDL, HbA1c ↓

BP/HR, CVD risk ↓

Moderate
43411
Grape Seed Extract

Lipids, −20% LDL

Blood pressure, −13.1 mmHg

Oxidative stress, −37.5% CRP

Moderate
4413
Epigallocatechin Gallate

Lipids ↓; heart risk

BP/HRV improved; heart risk

Endothelial/oxidation improved

Moderate
10919
Betaine

Homocysteine −24%

CVD risk HR≈2.2

Moderate
11816
Hibiscus

Blood pressure −20 mmHg

Lipids/glucose improved

Moderate
3413
Saffron

Lipids↓ TG/LDL

Blood sugar↓ FBG/HbA1c

BP/inflammation↓

Moderate
10718
Hawthorn

Exercise capacity, symptoms

BP/cardiac workload, inflammation

Moderate
16016
Spirulina

Blood pressure, stiffness

Lipids, glucose, inflammation

Moderate
5518
Black Seed Oil

BP & lipids improved

Heart function protected

Moderate
4915
Senna

Stool more frequent

Transit faster

Moderate
945
Terminalia Arjuna

Pump function +5.1% LVEF

Lipids/angina ↓; FMD +4.1

Moderate
3315
Chlorogenic Acid

Endothelial function +FMD

Blood pressure/lipids ↓

Insulin resistance/lipids ↓

Moderate
4616
Cinnamon

Better glucose control

Lipids/BP down

Moderate
6114
Bergamot

LDL/TG down

Inflammation/vascular markers improved

Moderate
3515
Chitosan

LDL/ApoB↓, HDL↑

BP control↑, bleeding↓

Moderate
11618
Jujube

Heart risk factors down

TC/LDL/TG lower

+2.8 HDL

Moderate
1813
Artichoke Extract

Lipids down; HDL up

Inflammation down; vascular up

Moderate
2513
Piperine

Lipids/glucose ↓; HDL ↑

LDL -18 mg/dL

Moderate
5118
Lupin

Lower LDL/total cholesterol

Better LDL:HDL ratio

Moderate
20312
Glucomannan

LDL/TC ↓ ~10-22%

Triglycerides/BP ↓

Moderate
3212
Riboflavin

Homocysteine ↓ 22-40%

BP ↓ 5-9 mmHg

Moderate
32415
Conjugated Linoleic Acid

Lower LDL, BP

HTN risk -34%

Lower TG, LDL

Moderate
11014
Krill Oil

TG/LDL ↓ ~10%

Omega-3 ↑ 2x

Moderate
3815
Cranberry

Vessels: FMD↑, PWV↓

Lipids/Inflammation: LDL↓, CRP↓

Moderate
11014
Avocado

LDL/total cholesterol ↓

Blood vessel function ↑

Triglycerides/insulin ↓

Moderate
4716
Pine Bark Extract

Endothelial health, +41%

Blood pressure, -7.5

Moderate
5318
Red Clover

Arterial compliance +23%

LDL/HDL improved

Blood pressure -8/-4

Moderate
4010
Astaxanthin

Lipids/oxidative stress

Glucose/endothelial

Moderate
5617
Bilberry

Vessel function: +28.4% FMD

Blood pressure: -6.9 mmHg

Moderate
278
Ubiquinol

EF +7-8%

Inflammation -59%

Moderate
3115
Vitamin B1

Pump function +5.3%

Diuresis, injury↓

Moderate
26717
Carnosine

Better heart pump

↓ inflammation, BP

Moderate
7717
Thiamine

Heart function +3.9%

Cardiac injury -61.5%

Moderate
20515
Naringenin

Stiffer arteries -0.34 m/s

Lower CVD risk HR 0.80

Better lipids/BMI

Moderate
166
Perilla Oil

Lipids↓, HDL↑

Inflammation↓

Moderate
77
Black Garlic

Lipids improve; DBP -4.8 mmHg

Cholesterol, triglycerides, HDL/ApoB

Moderate
75
Pea Protein

Cholesterol −4.7 to −6.4%

Systolic BP −5 mmHg

Moderate
4514
Amla

Lipid lowering

Platelet/endothelial support

Moderate
2913
Black Currant

Endothelial function, BP -6

Inflammation/lipids, FMD +28%

Moderate
5113
Ellagic Acid

Lipids ↓; FMD ↑

BP/stiffness ↓; eNOS ↑

Moderate
2515
Chia Seeds

Blood pressure ↓ 8.8

Atherogenic lipids ↓ 18%

Moderate
118
Royal Jelly

Vascular/inflammation +21%

Lipids/cholesterol -23%

Inflammation/enzymes -19%

Weak
2712
Lecithin

LDL down ~10%

HDL up, glucose down

Small LDL reduced

Weak
14213
Beet Root

Blood pressure ↓

Endothelial function ↑

Weak
107
Urolithin A

Vessel function +1.6%

Lower CVD risk 52%

VAT loss −14.1%

Weak
1517
Olive Leaf Extract

Lower BP, TG

Less stiffness, IL-8

Weak
1713
Gamma Oryzanol

BP -7.6 mmHg

LDL/triglycerides down

Weak
148
Mulberry

Blood pressure -10/6

Lipids/glucose/inflammation lower

Arteries/events improved

Weak
4912
Spermidine

Endothelial function +0.31

Nitric oxide, spermidine

Weak
2611
Cod Liver Oil

Omega-3↑; triglycerides↓

HDL↑ 7%; TG↓

Platelet aggregation↓; cholesterol↔

Weak
3010
Blueberry Extract

Memory + BP

-7 mmHg SBP

Faster executive response

Weak
610
Cornelian Cherry

Weight/waist, HDL↑

Glucose/lipids improved

Weak
57
Nattokinase

Clotting slowed; PT/aPTT↑

BP lowered; renin↓ (-5.6/-2.8)

Weak
85
Reishi

Oxidative stress ↓

Lipids improved −22%

Weak
1511
Fenugreek

Lipids improved heart markers

HDL/LDL +32%

Cholesterol, TG down

Weak
3213
Mangosteen

Weight/waist −5.2 kg

Lipids improved; TG −42%

Weak
1510
Chlorella

BP ↓; LDL/TC ↓

VO2max, SV/CO ↑

-14% LDL, +10% TC

Weak
1812
Kelp

Heart rate -4%

IL-6 -

LDL -28.3%

Weak
4812
Moringa

Lipids/BMI ↓

SBP -9.2%

Weak
2512
Capsaicin

Lipids, glucose ↓

Blood pressure ↓

Weak
24618
Acai Berry

Blood flow +1.4%

HDL +7.7%

Weak
68
Hemp Protein

BP −8.9/−5.8

HDL/FA profile

Body fat/HDL

Weak
306
Rose Hip

BP, LDL -6%

Inflammation, fibrinogen -42%

Weak
5210
Dong Quai

Cardiac events -4.6%

Kidney function +3.2

Weak
155
White Mulberry

BP, TG, CRP -10/-14

LDL, glucose, HbA1c -22%

Weak
1210
Coptis

Lower BP, waist -1.5 cm

Heart strain reduced

Weak
913
Noni

↓ lipids, inflammation

↑ HDL, -24% homocysteine

Weak
76
Sulforaphane

LDL-C down more

TC/HDL-C unchanged

Weak
4214
Green Coffee Extract

BP ↓; +FMD

+Glucose/waist ↓

Weak
148
Acacia Fiber

HDL↑, SBP↓ 10 mmHg

VAI↓ 0.75

Weak
156
Ecklonia Cava

BMI/cholesterol down

HDL up

Weak
36
Borage Oil

Blood pressure ↓

Triglycerides ↓ HDL ↑

Weak
168
Bitter Melon

Triglycerides -14 mg/dL

HbA1c -1.15%

Weak
107
Rutin

Clot-busting, flow +venous

RBC aggregation, viscosity -

Weak
8613
White Kidney Bean

Vascular stiffness, BP

LDL: -8%

Weak
510
Japanese Knotweed

Artery plaque, IMT ↓

Inflammation ↓ more than control

Weak
24
Guggul

Cholesterol/triglycerides -12%

Lipid peroxides -33%

Weak
73
Dihydromyricetin

LDL, glucose down

insulin resistance down

Weak
25
Salacia Reticulata

Lipids, glucose −23.7%

Inflammation, kidney stability

Weak
1110
Kombucha

LAP -8.7; IL-6 rise blunted

Better saliva microbes; heart risk

Weak
36
Acetyl-L-Carnitine

Autonomic support, +HRV

MIBG preservation, -14% loss

Weak
9017
Kaempferol

↓Triglycerides −15%

↓LDL, oxidative stress

Weak
1311
Myricetin

Triglycerides -15%

LDL/oxidative stress

Weak
49
Artemisinin

QTc +28 ms

No QTc change

Weak
83912
Goji Berry

HDL +0.08 mmol/L

CVD risk -0.8%

vascular age -1.9y

Weak
1917
MCT Oil

LDL/TC down 9–16%

Post-meal TG down 73%

Weak
5311
Pumpkin Seed Oil

HDL↑, BP↓

AIx/BP↓

Weak
58