Proof.Fit

Betaine

16 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Cholesterol
Strong

LDL-C ↑; betaine varies

Homocysteine ↓; betaine ↑

6,853 people
Metabolism
Strong

Betaine↑, Hcy↓

Betaine ↔ glucose

5,480 people
Detoxification
Moderate

Betaine lowers Hcy

Betaine boosts methylation

2,667 people
Heart health
Moderate

Homocysteine −24%

CVD risk HR≈2.2

2,476 people
Brain health
Moderate

Methylation/cognition: −36% Hcy

Choline/betaine brain support

1,265 people
Cell health
Moderate

Homocysteine ↓ 10–24%

Betaine/choline ↑, Hcy ↓

B12/IGF-1 ↑

1,085 people
Weight management
Moderate

BMI/body fat ↓

Fat loss markers ↓

Liver enzymes ↓

1,119 people
Healthy aging
Moderate

Lower homocysteine 36%

Better memory, betaïne

Oxidative stress down

585 people
Illness recovery
Moderate

Inflammation↓ 40%

Healing/bacteria↓

Performance↑

579 people
Muscle maintenance
Weak

Strength, lean mass +5.9%

Anabolic signaling, hormones

110 people
Workout performance
Weak

Strength/hypertrophy ↑

Endurance/performance ↑

110 people
Liver support
Weak

Fat loss, lower enzymes

CAP/TE ↓, BMI ↓

753 people
Body composition
Weak

BMI/body fat ↓

Lean mass ↑

362 people
Digestive support
Weak

Saliva flow, dryness −

Choline, fat absorption +

Gastric acid/absorption +

150 people
Acne
Weak

Less irritation, no acne change

AE −4.2 pp, no acne

81 people
Focus & concentration
Weak

Better mood/focus

+focus, no gains

80 people