proof.fit

Betaine

16 benefits mapped to clinical evidence across supplements.

Benefit Evidence

LDL-C ↑; betaine varies

Homocysteine ↓; betaine ↑

6,853 people

Betaine↑, Hcy↓

Betaine ↔ glucose

5,480 people

Betaine lowers Hcy

Betaine boosts methylation

2,667 people
Heart health
Moderate

Homocysteine −24%

CVD risk HR≈2.2

2,476 people
Brain health
Moderate

Methylation/cognition: −36% Hcy

Choline/betaine brain support

1,265 people
Cell health
Moderate

Homocysteine ↓ 10–24%

Betaine/choline ↑, Hcy ↓

B12/IGF-1 ↑

1,085 people

BMI/body fat ↓

Fat loss markers ↓

Liver enzymes ↓

1,119 people

Lower homocysteine 36%

Better memory, betaïne

Oxidative stress down

585 people

Inflammation↓ 40%

Healing/bacteria↓

Performance↑

579 people

Strength, lean mass +5.9%

Anabolic signaling, hormones

110 people

Strength/hypertrophy ↑

Endurance/performance ↑

110 people

Fat loss, lower enzymes

CAP/TE ↓, BMI ↓

753 people

BMI/body fat ↓

Lean mass ↑

362 people

Saliva flow, dryness −

Choline, fat absorption +

Gastric acid/absorption +

150 people
Acne
Weak

Less irritation, no acne change

AE −4.2 pp, no acne

81 people

Better mood/focus

+focus, no gains

80 people

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Betaine

Search all

59 products whose verified label declares Betaine — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.