Soy Isoflavones

16 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects

LDL/TC ↓, BP ↓

Endothelial function ↑

Inflammation/oxidation ↓

Strong

4,329

Hormone balance

Hot flashes/symptoms −40–61%

Estrogen metabolism +31% ratio

Androgens/FSH down

Strong

4,374

LDL/TC down

HDL slightly up

Strong

3,481

Spine/hip BMD ↑

Resorption markers ↓

Strong

3,590

Androgens/PSA ↓

Estrogen shift 2:16↑

Breast density ↓

Strong

11,666

CRP/IL-6 ↓

sICAM-1/VCAM-1 ↓

COX-2/PGE2 ↓

Strong

2,161

Blood circulation

BP -18/16 mmHg

LDL -6-9%

FMD +1-5 pp

Strong

1,661

MDA ↓, TAC ↑

OxLDL ↓, FMD ↑

Moderate

935

Weight management

↓ fat mass/weight

↓ insulin resistance

Moderate

536

Hot flashes/symptoms ↓

Vaginal health ↑

Moderate

507

Wrinkles ↓, +10%

Hydration/pigment improved

Collagen ↑

Moderate

293

Urinary comfort

Urinary leakage -9.5%

Mild symptom relief

Moderate

308

Mood symptoms ↓

Depression/anxiety ↓

Moderate

252

Memory/fluency +8.5%

Planning/speed +7%

Moderate

167

Muscle/joint pain -10

Hot flashes, dose-related

Weak

102

Sleep quality improved

NHP sleep p<0.001

Weak

60