Proof.Fit

Antioxidant

133 supplements analyzed and ranked by clinical evidence.

Supplements133

Supplement Evidence

Main Effects
Vitamin E

↑Vit E; ↓ox stress

↓Liver enzymes; ↑Vit E

Strong
181517
Vitamin C

Liver enzymes ↓ALT 63%

Antioxidant status ↑

Strong
151318
Beta-Carotene

Antioxidant↑, Oxidation↓

+15-fold beta-carotene

AMD risk↓, +10pp

Strong
80713
Selenium

GPx↑, oxidative stress↓

Se status↑, GPx↑

Strong
69617
N-Acetyl Cysteine

Glutathione+oxidative stress

Ongoing pregnancy +24.2pp

Hepatotoxicity -37.5pp

Strong
62317
Alpha-Lipoic Acid

Oxidative stress ↓

Antioxidant capacity ↑

Strong
21217
Coenzyme Q10

↓ Oxidative stress

↑ Antioxidant enzymes

MDA -31%

Strong
34817
Lutein

Blood lutein +5×

Oxidative damage ↓

Strong
2588
Curcumin

Antioxidant↑, MDA↓

Inflammation↓, TAC↑

Strong
36418
Vitamin A

Oxidation↓; A/E↑

β-carotene↑; retinol↔

Strong
130714
Copper

Antioxidant enzymes +9%

Oxidative stress -39%

Strong
64718
Lycopene

Antioxidant capacity ↑

Oxidative stress ↓

Strong
19618
Anthocyanins

antioxidant↑, TBARS↓

TAC↑, ROS↓

8-OHdG↓, oLAB↓

Strong
13119
Glutathione

GSH detox +20-60%

Oxidative damage ↓

Airway GSH ↑3-4x

Strong
124419
Green Tea Extract

Antioxidant capacity ↑

Oxidative damage ↓

Strong
24417
Danshen

SOD↑, MDA↓

LPO↓, GSH-Px↑

ET-1↓, NO↓

Strong
12117
Bitter Orange

Antioxidant +43.9% ORAC

Oxidative stress -30% TBARS

Strong
25113
Pomegranate

TAC ↑, MDA ↓

Oxidative stress ↓

Strong
10416
Resveratrol

Antioxidant +40%

Oxidative stress −39%

Strong
17619
L-Methionine

Glutathione↑, MDA↓

Selenium/antioxidants↑

Strong
34317
Astaxanthin

Lower MDA/TAC +

+SOD, -MDA

Lower CK/AST +

Strong
5617
Ginseng

Oxidative stress ↓

+SOD / +TAS

Fatigue ↓ 7

Moderate
27118
Manganese

MnSOD ↑, MDA ↓

Oxidative stress ↓

Moderate
8714
Turmeric

Oxidative stress↓

NTBI↓21.6%

Moderate
19419
Zeaxanthin

Carotenoids ↑ antioxidant status

Oxidative damage ↓, MPOD ↑

+70% xanthophylls

Moderate
1567
Carnosine

Oxidative stress ↓

Antioxidant capacity ↑

Redox markers improved

Moderate
7717
Ginkgo Biloba

Oxidative markers ↓

SOD/GSH ↑

+46% responders

Moderate
22317
Saffron

Antioxidants +TAC

Oxidative stress -MDA

Inflammation ↓ hs-CRP

Moderate
10718
Pine Bark Extract

Oxidative stress ↓

Antioxidant status ↑

Moderate
5318
Soy Isoflavones

MDA ↓, TAC ↑

OxLDL ↓, FMD ↑

Moderate
35516
Garlic

Oxidative stress/LDL oxidation

+34% / -32%

Antioxidant status / TAC

Moderate
15317
Quercetin

Antioxidant ↑ +7 min

Oxidative stress ↓

Bioavailability ↑ 20-fold

Moderate
14219
Phytosterols

LDL↓, oxidation↓

ApoA1↑, oxidation↓

Moderate
30617
Grape Seed Extract

Antioxidant markers +52%

Oxidative stress ↓

Inflammation ↓

Moderate
4413
Propolis

Antioxidant↑, stress↓

Oxidative markers↓, capacity↑

Moderate
9516
Hesperidin

Antioxidant capacity ↑

+13% TAC

Oxidative damage ↓

Moderate
6416
Vitamin B2

Antioxidant ↑, MDA ↓

Homocysteine ↓, TAC ↑

Moderate
40015
Epigallocatechin Gallate

Antioxidant capacity +16–19%

Oxidized LDL −3.15 U/L

Moderate
10919
Flaxseed Oil

↑ TAC, ↓ MDA

↓ Ox-LDL 25%

Moderate
11617
Ubiquinol

Oxidative markers ↓, enzymes ↑

CoQ10/NO ↑, LPO ↓

FMD/LVEF ↑, injury ↓

Moderate
3115
DMSO

Oxidative stress ↓

GSH ↑

Moderate
8712
Ginger

Antioxidants up: TAC/GPx

+22%

Oxidative stress down: MDA

Moderate
23618
Black Currant

Oxidative stress ↓

Glucose/FMD/BMD ↑

Moderate
5113
Chlorogenic Acid

Antioxidant capacity +

Oxidative stress -40%

Antioxidant enzymes +52%

Moderate
4616
Astragalus

SOD↑, MDA↓

Oxidative markers↓, LVEF↑

Moderate
14917
Piperine

↓MDA/↑GSH

↑SOD/↓CRP

Moderate
5118
Spirulina

Antioxidant boost +56µM

Oxidative stress ↓

Moderate
5518
Black Walnut

Antioxidant ↑ ORAC/enzymes

Oxidative stress ↓ MDA

Moderate
8515
Avocado

Carotenoid uptake +12.6×

Oxidative stress ↓, antioxidants ↑

Moderate
4716
Rutin

Oxidative stress↓, GSH↑

TAC↑, BAP↑

Moderate
8613
Cranberry

TAC/MDA: +47%, −50%

SOD/GPx: increased

Moderate
11014
Goji Berry

SOD/GSH-Px +8–10%

MDA −9%

Total antioxidant +57%

Moderate
1917
Yerba Mate

Antioxidant↑ PON‑1 +10%

Glucose/Inflammation↓ −10%

Moderate
139
Terminalia Arjuna

Endothelial + nitric oxide

Oxidative enzymes +29%

Lipid/LDL -15.8%

Moderate
3315
Black Seed Oil

Oxidative stress -MDA

Antioxidant enzymes +SOD

Moderate
4915
Acai Berry

Antioxidant ↑

Oxidative stress ↓

Moderate
68
Milk Thistle

Antioxidant ↑ SOD/GPX

+12.85%

+30.32% GPX

Moderate
5114
Ellagic Acid

Antioxidant capacity +55%

Oxidative markers -40%

Moderate
2515
PQQ

Antioxidant ↑ TAC, GSH

Lipid peroxidation ↓ MDA/8-isoprostane

Moderate
68
Sesamin

↓ oxidative stress markers

↑ antioxidant defense

Moderate
78
Beta-Sitosterol

LDL↓ 6-14%

Carotenoids↓; tocopherol↑

Oxidative stress↓

Moderate
6711
Ashwagandha

Antioxidant + levels

Antioxidant +0.

Moderate
5018
Moringa

↑SOD/CAT, GPx

↓MDA, cholesterol

+endurance, milk yield

Moderate
2512
Bilberry

Antioxidant enzymes + TEAC

Skin FRAP +20.8%

MDA -

Moderate
278
Kudzu

Inflammation/endothelium ↓

Oxidative markers ↑

Moderate
1911
Policosanol

Lipid oxidation +21%

HDL/LDL shifts

Moderate
6512
Royal Jelly

↑SOD/PON1, ↓MDA

PON1 +8.4%

MDA ↓, SOD ↑

Weak
2712
Chlorella

Antioxidant↑, DNA damage↓

Lutein/enzyme↑, PLOOH↓

Weak
1812
Sage

Oxidative stress markers ↓

Antioxidant enzymes ↑

Weak
52116
Hibiscus

Antioxidant ↑, MDA ↓

FRAP/TAC ↑, MDA ↓

Weak
3413
L-Histidine

Antioxidant markers +50%

Redox/oxidative stress changes

Weak
15916
Rosemary

Antioxidant enzymes +

Lipid/oxidative stress -

Weak
7715
Theobromine

Antioxidant +4-8%

Inflammation -75%

Weak
29412
Lemon Balm

Antioxidant ↑MDA↓

Vitamin E, ‑SH ↑

Weak
20011
Manuka Honey

Oxidative stress ↓

LDL/HDL, LDH improved

Weak
276
Taurine

SOD↑, MDA↓

Oxidative damage↓

Weak
24013
Wild Yam

Oxidative stress ↓, GSH +2.5

Antioxidant effect short-term, MDA ↓

Weak
1111
TUDCA

Antioxidant enzymes +

Oxidative stress -

MDA -

Weak
129
Amla

Oxidative stress ↓31.4%

DNA repair stable

LDL ↓21.8%

Weak
2913
Sulforaphane

Oxidative damage ↓17.6%

Lipid peroxidation ↓

Weak
4214
Bergamot

LDL-C ↓

Oxidative damage ↓

SOD1/PPARγ ↑

Weak
3515
Mulberry

Antioxidant +glutathione

Antioxidant -MDA

Weak
4912
Boswellia

AGEs/MDA ↓42%

Oxidative stress ↓

Weak
6014
Gamma Oryzanol

ROS/TNF-alpha ↓

ORAC +10.1%

Weak
148
Nettle

↑ TAC, SOD

↓ MDA, hs-CRP

Weak
375
Reishi

↓ Oxidative damage

↑ Antioxidant capacity

Weak
1511
Kelp

↑SOD/GPx/GSR; ↓oxidation

↓MDA/γ-GT; ↑SOD

Weak
4812
Red Yeast Rice

OxLDL −20%, MDA ↔

LDL −24%, BP −10

Weak
6814
Rose Hip

Oxidative markers -37%/-42%

Skin/barrier improves

Insulin response lowers

Weak
5210
Cocoa Extract

Polyphenols +50.5

Oxidative stress ↓

Vascular function ↑

Weak
407
Wormwood

TBARS ↓

Lactobacillus ↑

Weak
479
Bacopa Monnieri

Oxidative stress: GSH +37%

Inflammation: CRP/TNF-α lower

Weak
1311
Chlorophyll

Aflatoxin biomarkers −55%

DNA damage −45%

Weak
1310
Echinacea

Collagen, elasticity up

MDA down

Weak
5413
Gotu Kola

Elasticity, collagen ↑

Lipid oxidation ↓

Weak
3814
Diosmin

GPx +22%

LDL lag +16%

MDA down

Weak
598
Fenugreek

TAC up; MDA down

Memory improved

Weak
3213
Artichoke Extract

TAC ↑; ox-LDL ↓

cholesterol ↓

Weak
2513
Neem

Blood sugar control

Endothelial/oxidative stress

Weak
1913
Red Clover

Hot flashes −10.4

Quality of life ↓3.4

Equol production ↑2.8x

Weak
4010
Jujube

Antioxidant↑ GSH, MDA↓

Insulin resistance↓

Weak
1813
Benfotiamine

Cognition/AGE −1.9

DNA damage/antioxidants

Weak
209
Barley Grass

↓ genotoxicity

↓ cytotoxicity

Weak
5915
Asafoetida

Oxidative stress ↓

BMI ↓

Weak
39
Chamomile

Antioxidant enzymes +46%

Antioxidant capacity +7%

Weak
7817
Guggul

Lipid peroxides -33.3%

Cholesterol, LDL, TG -12%

Weak
73
Cornelian Cherry

Oxidative stress ↓

MDA ↓

Weak
57
Pterostilbene

GSH +11%

Safety stable

Weak
55
Shilajit

BMD ↑, +dose

Oxidative stress ↓

Weak
68
White Mulberry

↓MDA, ↓insulin

↑HDL-C

Weak
1210
Kombucha

H2O2 -19%

No other changes

Weak
36
Baikal Skullcap

SOD/GSH-Px +23%

MDA/LPO down

Weak
157
Skullcap

SOD/GSH-Px +23%

TAOC↑ MDA↓

Weak
2511
Elderberry

Plasma/urine metabolites up to 33,185

Anthocyanin conjugates up to 548

Weak
209
Hops

Anti-inflammatory −43–64%

Oxidative damage ↓

Bioavailability +235–320%

Weak
489
Green Coffee Extract

Skin hydration, FMD +1.2%

Barrier + blood flow

Weak
148
Cat's Claw

Pain, scores ↓

TNF-alpha inhibition

Weak
44
Jasmine

Antioxidant +0.1 mg/ml

Skin aging +p<0.05

Weak
373
Kaempferol

Oxidative stress −68%

Lipids/inflammation lowered

Weak
1311
Myricetin

Antioxidant ↑ TAC, -33%

Lipid peroxidation ↓ 20-27%

Weak
49
Uva Ursi

Glucose -27%

CRP -59%

ALT/AST/GGT down

Weak
82
Black Pepper

Carotenoids uptake +4.8x

Oxidative stress ↓ MDA

Weak
3713
Calendula

DNA/lipid damage ↓

isoprostane trend ↓

Weak
257
Matcha

Matcha: TAC↑, PI/BOP↓

Green tea: PI/BOP↓

Weak
1113
Schisandra

Antioxidant capacity +

ALT/AST decrease

Weak
1214
Siberian Ginseng

LDL, -17.21 mg/dL

Oxidative damage markers down

Weak
2111
Passion Flower

Inflammation markers ↓

Insulin/BP/HR ↓

Weak
207
Burdock Root

TAC +

IL-6/hs-CRP -

Weak
23
GlyNAC

GSH restored

oxidative stress ↓

mitochondria improved

Weak
16
Tart Cherry

Oxidative stress ↓

Inflammation/CRP ↓

Weak
158
Ergothioneine

Mood maintained; BDNF ↓

Inflammation ↓ (nitrite, NOX2, iNOS)

Weak
14
Rooibos

GSH sustained; MDA unchanged

DNA damage unchanged

Weak
21
Tribulus Terrestris

↑Antioxidant status +10%

↓Oxidative damage / CK

Weak
239