Diosmin

Venous tone/hemodynamics

Edema/symptoms -1.3%

Microcirculation/ulcers/healing

Capillary strength +60 mmHg

Venous symptoms -PTS 8.9%

Inflammation/edema improved

Bleeding −5.2pp

Swelling/pain better

DVT/PE 1.3%→0

Reduced limb edema

Venous function improved

Bleeding/pain ↓

Symptom score −5.5

Attack duration/frequency ↓

Less cramps via swelling ↓

Pain relief, edema ↓

Pain/bleeding down

CRP/IL-1/TNF-α down

GPx +22%

LDL lag +16%

MDA down