Inflammation
149 supplements analyzed and ranked by clinical evidence.
Supplement Evidence
Liver inflammation ↓ / ALT
Systemic inflammation ↓ / CRP
Lower IL-6/WBC
Liver injury markers
-53 U/L ALT
Lobular inflammation ↓
CRP/IL-6 ↓
anti-inflammatory, -32.7%
glutathione boost, cytokines down
Inflammation↓ CRP/IL-6
Inflammation↓ TNF-α/IL-6
Inflammation↓ CRP -15%
Anti-inflammatory + CRP↓
Allergy/eczema ↓ ~50%
↓AA eicosanoids
↓platelet aggregation
↑EPA/AA ratio
Liver enzymes/inflam ↓
SCFAs/endotoxin/inflam ↓
ALT/CRP down
~50% lower inflammation
Fewer liver enzymes
Lower skin inflammation
-45% MMP-9
Less acne irritation
Inflammation↓ CRP/TNF-α
Inflammation↓ plaques/gingivitis
Inflammation↓ diarrhea/infection
Inflammation ↓ CRP/IL-6
Oxidative stress ↓ MDA
SCFA↑, UC inflammation↓
Butyrate↑, cytokines↓
CRP/WBC ↓
TNF-α/IL-6 ↓
MDA/TAC shift
Infection↓ CRP↓
IL-6/TNF-α↓
SIRS/MOF↓
IL-6/TNF-α/CRP ↓
PGE2/hsCRP ↓
NF-κB/cytokines ↓
CRP/TNF-α ↓
Inflammation ↓ CRP/cytokines
Inflammation ↓ leukotrienes/prostaglandins
Inflammation ↓ gene expression
CRP/IL-6 ↓
sICAM-1/VCAM-1 ↓
COX-2/PGE2 ↓
Lower CRP/TNF-α
↓ inflammatory markers
IL-6/hs-CRP down
Inflammation↓ hsCRP -39%
Oxidative stress↓ ROS/lipid peroxidation
Inflammation markers ↓
CRP -38%
TNF-α/IL-6 ↓
Anti-inflammatory skin flare ↓
CRP, eosinophils ↓
Sensory inflammation ↓
Inflammation ↓ (IFN-γ, CRP, IL-6)
Inflammation ↓ (TNF-α, IL-10)
Cytokines ↓ inflammation
CRP/ET/NO ↓
CRP/IL-6↓
JAK/STAT, TNF-α↓
hs-CRP −0.23
Inflammation ↓; CRP/IL-6
Inflammation ↓; 35%→20%
Fibroinflammation ↓; ALT −4.8%
Inflammation↓ hs-CRP/IL-6
Oxidative stress↓ TAC↑
NF-κB↓ SIRT1↑
Inflammation ↓ hs-CRP -6.8%
Cytokines ↓ TNF-α/IL-6
Endothelial/oxidative ↓
↓ inflammation markers
↓ cytokines/CRP
−64% WOMAC/−67% VAS
CRP/TNF-α ↓
IL-6/hs-CRP ↓
-29%, -47%
Lower TNF/IL-6
Faster clearance, +1.3%
Inflammation ↓ ulcer/colitis
Inflammation ↓ IC/BPS symptoms
Inflammation ↓ gastric injury
Inflammation −42.9 mg/L
Inflammation −3.3 pg/mL
less inflammation, pain
−50% swelling, better healing
lower cytokines, skin redness
Inflammation↓ IL-6/CRP
Inflammation↓ TNF-α/IL-10
+140% IL-10
Lower CRP/endotoxin
Gut inflammation repair
↓CRP -5.9 mg/L
Skin inflammation ↓
IL-17A ↓4.4-fold
CRP/TNF-α ↓
PGE2 ↓
Lower cytokines, markers
Skin/gum inflammation ↓
Acute postmeal inflammation ↓
IL-6/CRP↓, SAA−24.5%
NOX/ROS↓, MMP-2/9↓
↓ IL-6, hs-CRP
↓ IL-4, 32%
Inflammation genes −3,422
CRP/IL‑6/TNF‑α ↓
Adhesion markers ↓
Lower inflammation markers
IL-6/CRP/LEU ↓
Reduced tissue inflammation
TNF-α/CRP ↓
IL-6/leptin ↓
MDA/endothelial ↓
LDL/CRP ↓20-30%
Inflammatory markers ↓
Inflammation/itch ↓; hydration ↑
Pain/resolution improved: +98%/96%
URTI episodes ↓: 39 vs 64
↓IL-6/TNF-α
↓CRP/ESR
Oral inflammation −25.6%
Systemic inflammation, CRP
Inflammation ↓, markers
Inflammation −53%, immune cells
Inflammation ↓, symptoms
Inflammation↓ LPS
Cytokines↓ TGF‑β1↑
Akkermansia↑; LPS↓
Joint pain/function -26%
Inflammation markers ↓
Systemic inflammation ↓
Tear cytokines ↓
CRP -30.9%
↓ IL-6/CRP/lymphocytes
↓ gingival inflammation
↓ TNF-α/hsCRP
↓ inflammatory genes
IL-6/CRP ↓
CRP -7.1
Inflammation markers ↓
ESR/CRP↓, IL-6↓, MPO↓
CRP/IL-6/TNFα ↓
Oxylipins/oxLDL ↓
IL-6/IL-8/TNF-α ↓
CRP/IL-8 ↓
Lower hs-CRP
↓6.8%
↓26.8%
Inflammation markers down
TNF-α, ICAM-1
hs-CRP down
Systemic inflammation ↓ CRP
Local gingival inflammation ↓ IL-1β/PGE2/MMP-8
Inflammation markers ↓
CRP/cytokines ↓
MPO -75%
↓TNF-α/IL-1β
↓ESR/hsCRP
Inflammation down: acne, gum
Inflammation down: ARDS, neutrophils
Inflammation down: LTB4 -50%
Gut recovery; CRP↓
UV redness↓
Inflammation ↓ CRP/IL-18
Immune markers altered
↓ IL-6/CRP, MPO
↓ IL-8/leukotrienes
Inflammation+joint pain -0.52
Inflammation+colon response +12%
IL-6, TNF-α ↓
IL-6 ↓ (subgroup)
IL-6 -
Oxidative stress ↓
Oral inflammation ↓
Eye inflammation ↓
Edema/symptoms ↓; -12.9%
Limb size/symptoms ↓
↓IL-6/IL-8, SCORAD
↓CRP −10.5 mg/L
Inflammation ↓ IL-6, F2-iso
Inflammation ↓ fibrinogen
Inflammation ↓ hs-CRP
NE/IL-6 ↓
NLRP3/IL-1 ↓
Inflammation down: CRP/ESR
TNF-α −67%, joints/remission
Pain/function improved
Inflammation ↓ IL-6/TNF-α
CRP/ESR ↓; symptoms ↓
Gut bacteria ↑; SCFAs ↑
Inflammation: hs-CRP -24%
Inflammation: UAS7 improved
Inflammation ↓ CRP -1.94
Inflammation ↓ markers
Inflammation ↓ healing score
Inflammation/immune ↓
Markers+symptoms
CBD/THC: strong ↓
CRP/MMPs ↓
MCP-1 ↓
Pain/bleeding down
CRP/IL-1/TNF-α down
↓ TNF-α, cytokines
↓ plaque/bleeding, bacteria
Inflammation down; hs-CRP
Cytokines down; IL-6
PGD2/symptoms down
Inflammation markers down
Pain/joint scores down
CRP/ESR/RF/CCP-Ab ↓
↓ pain/PGE2 ~25%
↓ IL-1β/IL-6/IL-8
Anti-inflammatory markers ↓
Pain/swelling ↓ 37%
Pain/function ↓
IL-6/CRP ↓
-10 tabs/week
CRP −1.03; inflammation down
Inflammation attenuated; markers improved
CRP ↓, IL-2 ↓
Acylcarnitines/ceramides ↓, CRP ↓
Anti-inflammatory shift
DAS28 -1.08
IL-6 -69%
Lower inflammation markers
+34.1% NK activity
Reduced oxidative stress
Gastric inflammation ↓; H. pylori
IL-6/TNF-α ↓; inflammation
MDA ↓; gastric inflammation
Inflammation ↓ IL-6, hsCRP
Inflammation ↓19%, hsCRP lower
Oxidative stress ↓
T-cell anti-inflammatory shift
Pain/function improves
Airway inflammation drops
Inflammation ↓ IL-10 +2.2
Oral inflammation ↓ PI/BOP
Gingival inflammation ↓ bacteria
Staph/toxin↓, IL-8↓
Colonization↓, severity↓
Inflammation ↓: CRP/TNF‑α
Inflammation ↓: PGE2/COX‑2
Inflammation ↓: IL‑6/TGF‑β
↓ JAK/STAT, autophagy
↓ skin inflammation ~37%
↓ lung inflammation, faster recovery
Inflammation↓ hs-CRP -6.8%
NLRP3/IL-1↓
↓ inflammatory markers
immune shift
hs-CRP ↓
Inflammation markers ↓
hs-CRP ↓11%
LDL-C/TG ↓
TNF-α ↓
hs-CRP 3.1→1.2
IL-6 rise blunted -42%
Glucose/IR improved
Heart rate lowered -4%
hs-CRP, TNF-α ↓
IL-6, ~15% ↓
↓ hs-CRP, TNF-α
↓ prostaglandins, hs-CRP
CRP ↓1.1 mg/L
Inflammatory markers ↓
UC: symptoms -20%, fatigue
Crohn’s: stool freq, pain +17%
Symptoms -33.5%/-57%
IL-10 up; TNF-α/IL-13 high
IL-6/CRP ↓
Homocysteine ↓
Pain, joints ↓53%
TNF-alpha inhibition
Pain ↓53%
Inflammation markers ↓
Joint scores ↓
20-HETE -30%
RA inflammation ↓
Less phlebitis, +20.3% success
Vessel diameter +3.57 mm
CRP −23%; urate −37%
UACR/CRP lower; fewer flares
IL-6/8 down ~55-76%
IL-10 up ~266%
hs-CRP -15%
lipids down 20-41%
Colitis score, TNF-α ↓
ESR, fibrinogen, IL-6 ↓
Swelling reduced, day2
Mouth opening improved, 73%
↓ inflammatory markers
↓ TG/VLDL
ALT, GGT lower
ceramide 14:0 down
itching, dyspareunia, dysuria
greater symptom decrease
hs-CRP/TNF-α ↓
IL-6 ↓
PCR clearance; hs-CRP -12.4x
IL-6/TNF-α lower
Inflammation scores -1.59
Healing +54.67%
Pain/opioid ↓
Analgesic need ↓
Lower TNF-α/ROS
CRP −20.8%
Lesions -82.3%, relapses
Demodex -more reduction
Pain/analgesic ↓
Glucose/weight ↓
Relapse, lesions, disability
Cognition, MSFC, EDSS
Pain/disability ↓
WOMAC total ↓
Oxidative stress ↓
BMI ↓
↓ cortisol/NEFA
↓ haptoglobin
Erosion −44 vs −58.5
Pain −3, equal
hs-CRP ↓
TNF-α/IL-6 ↓
Pain ↓ -5.23
Flow/QOL changes
↓ inflammation markers
− glucose, LDL, HOMA-IR
Knee pain, stiffness
Gum inflammation −55%
Slough down; healing unchanged
Dressing changes -week 12
PASI ↓ greater
Metabolic markers improved
Erythema, SCORAD ↓
No adverse events
NFκB/MAPK↓
Insulin signaling↓
Inflammation down, IL-6 -2.0
Steatosis/ALT down, HOMA-IR down
CRP -59%; inflammation down
ALT lower; less inflammation
Lower nitrite, NOX2, iNOS
BDNF decreased dose-dependently
CRP -2.45 mg/L
AGEs -0.99 units
hs-CRP, IL-6/8 ↓
ALT/AST, HFF ↓