Palmitoylethanolamide

18 benefits mapped to clinical evidence across supplements.

Serves the goals:Bone & Joint Cognition Energy Essential Health Fitness

Benefit Evidence

Pain relief

Strong

Pain scores down

Pain/function improved

1,296 people

Wellbeing

Moderate

Pain/function ↓

Mood/anxiety ↓

Olfaction/QoL ↑

1,384 people

Daily comfort

Moderate

Pain/comfort up

+10% pain relief

Symptoms/function improved

1,197 people

Inflammation

Moderate

Inflammation/itch ↓; hydration ↑

Pain/resolution improved: +98%/96%

URTI episodes ↓: 39 vs 64

956 people

Muscle soreness

Moderate

Pain reduction

Inflammation/function

603 people

Nerve health

Moderate

Pain relief / sleep

Nerve conduction +≈33%

Inflammation down, cytokines↓

346 people

Mood balance

Moderate

Mood balance: better depression

Mood balance: less mania

317 people

Swelling relief

Moderate

Pain/inflammation ↓

Swelling markers ↓

593 people

Joint mobility

Moderate

Pain & function: improved

Joint mobility: +mouth opening

376 people

Stress resilience

Moderate

Stress resilience +faster symptom relief

Stress resilience -inflammation -11.5

312 people

Relaxation

Moderate

Mood/anxiety + response

Pain/sleep relief

226 people

Illness recovery

Moderate

IOP rise prevented

Smell recovery +9.2

448 people

Joint comfort

Moderate

Pain ↓

Function ↑

310 people

Focus & concentration

Weak

Brain fog, cognition +

Inhibition/plasticity, attention +

142 people

Workout performance

Weak

Pain/function improved

Lactate/myoglobin ↓

164 people

Healthy aging

Weak

Delirium −

Pain/function +

Vision/IOP +

151 people

Sleep quality

Weak

Pain ↓ sleep +

PSQI p<0.0001

108 people

Energy & Fatigue

Weak

Fatigue/cognition: GABAB + plasticity

Pain/inflammation: reduced pain, IL-6

100 people

Main Effects

Pain relief

Pain scores down

Pain/function improved

Strong

1,296

Wellbeing

Pain/function ↓

Mood/anxiety ↓

Olfaction/QoL ↑

Moderate

1,384

Daily comfort

Pain/comfort up

+10% pain relief

Symptoms/function improved

Moderate

1,197

Inflammation

Inflammation/itch ↓; hydration ↑

Pain/resolution improved: +98%/96%

URTI episodes ↓: 39 vs 64

Moderate

956

Muscle soreness

Pain reduction

Inflammation/function

Moderate

603

Nerve health

Pain relief / sleep

Nerve conduction +≈33%

Inflammation down, cytokines↓

Moderate

346

Mood balance

Mood balance: better depression

Mood balance: less mania

Moderate

317

Swelling relief

Pain/inflammation ↓

Swelling markers ↓

Moderate

593

Joint mobility

Pain & function: improved

Joint mobility: +mouth opening

Moderate

376

Stress resilience

Stress resilience +faster symptom relief

Stress resilience -inflammation -11.5

Moderate

312

Relaxation

Mood/anxiety + response

Pain/sleep relief

Moderate

226

Illness recovery

IOP rise prevented

Smell recovery +9.2

Moderate

448

Joint comfort

Pain ↓

Function ↑

Moderate

310

Focus & concentration

Brain fog, cognition +

Inhibition/plasticity, attention +

Weak

142

Workout performance

Pain/function improved

Lactate/myoglobin ↓

Weak

164

Healthy aging

Delirium −

Pain/function +

Vision/IOP +

Weak

151

Sleep quality

Pain ↓ sleep +

PSQI p<0.0001

Weak

108

Energy & Fatigue

Fatigue/cognition: GABAB + plasticity

Pain/inflammation: reduced pain, IL-6

Weak

100

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Glycine

Shares 9 benefits: energy & fatigue, focus & concentration, illness recovery, joint comfort

L-Dopa

Shares 9 benefits: daily comfort, energy & fatigue, focus & concentration, joint comfort

Boswellia

Shares 9 benefits: healthy aging, illness recovery, inflammation, joint comfort

Marijuana

Shares 9 benefits: daily comfort, focus & concentration, illness recovery, inflammation

Ashwagandha

Shares 8 benefits: energy & fatigue, focus & concentration, healthy aging, illness recovery

Vitamin D

Shares 8 benefits: energy & fatigue, healthy aging, illness recovery, inflammation

Products with Palmitoylethanolamide

Search all

21 products whose verified label declares Palmitoylethanolamide — not every bottle that mentions it in a title.

X Gold Health

Pea Palmitoylethanolamide + Turmeric Curcumin 1600mg 120 Capsules

Turmeric Complex · Turmeric Root Extract (Curcuma longa) 1000 mg · Turmeric Root Powder (Curcuma longa) +2 more

$36.90Turmeric

Biodepot

Biodepot 7 Day Liquid Probiotic Cleanse Sachets, Prebiotic Probiotic

lotal Fat 0 g · Includes 0g Added Sugars 0 g · Agaricus bisporus 10 mg +40 more

$28.98Prebiotics

Nature's Way

Nature's Way Alive! Everyday Immune Health* with Echinacea & Zinc

Vitamin A 900 mcg · Vitamin C 90 mg · Vitamin D3 20 mcg +26 more

$17.89Echinacea

Nature's Way

Natures Way Alive! Ultra Shake Energizer, Soy Protein Isolate

Vitamin A 15000 IU · Vitamin C 1 g · Vitamin D 1000 IU +126 more

$74.99Blends

NaturesPlus

NaturesPlus Source of Life Red Lightning Energy Drink Powder

RED LIGHTNING PROPRIETARY WHOLE FOOD BLEND 6000 mg · Grape Juice · Beet +44 more

$69.99Fruit Extracts

Nature's Way

Nature's Way Alive! Liquid Fiber Sugar-Free w/Prebiotics, 5g Fiber

Soluble Vegetable Fiber 8 g · NutraFlora scFOS 2 g · Orchard Fruits & Garden Veggies Powder Blend 100 mg +26 more

$13.82Dietary Fibers

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.

Sleep and Stress StudyPalmitoylethanolamide · Sleep Disorder (Disorder), Stress, Anxiety · 240 participants planned · ClinicalTrials.govRecruiting Levagen+ Efficacy Study on Diabetic Peripheral NeuropathyPalmitoylethanolamide · Diabetic Peripheral Neuropathy · 80 participants planned · ClinicalTrials.govRecruiting Training Health Recovery and Improvement Via Levagen+® EvaluationPalmitoylethanolamide · Exercise Recovery · 20 participants planned · ClinicalTrials.govRecruiting