Palmitoylethanolamide

Pain scores down

Pain/function improved

Pain/function ↓

Mood/anxiety ↓

Olfaction/QoL ↑

Pain/comfort up

+10% pain relief

Symptoms/function improved

Inflammation/itch ↓; hydration ↑

Pain/resolution improved: +98%/96%

URTI episodes ↓: 39 vs 64

Pain reduction

Inflammation/function

Pain relief / sleep

Nerve conduction +≈33%

Inflammation down, cytokines↓

Mood balance: better depression

Mood balance: less mania

Pain/inflammation ↓

Swelling markers ↓

Pain & function: improved

Joint mobility: +mouth opening

Stress resilience +faster symptom relief

Stress resilience -inflammation -11.5

Mood/anxiety + response

Pain/sleep relief

IOP rise prevented

Smell recovery +9.2

Pain ↓

Function ↑

Brain fog, cognition +

Inhibition/plasticity, attention +

Pain/function improved

Lactate/myoglobin ↓

Delirium −

Pain/function +

Vision/IOP +

Pain ↓ sleep +

PSQI p<0.0001

Fatigue/cognition: GABAB + plasticity

Pain/inflammation: reduced pain, IL-6