128 supplements analyzed and ranked by clinical evidence.
IBS relief +27%
Liver/gut markers
Diarrhea/constipation
Constipation relief +78%
Stool/gas + SCFA
IBS symptoms -38
Motility/+BM frequency
Cleansing/tolerance +10%
ALT/AST/GGT ↓
Digestion symptoms ↓ 70%
Bowel freq +38.5%
IBS symptoms −38.4pts
Stool softer/frequent
Cleansing + better tolerated
Constipation + faster stools
Acid/SCFA shifts, +10%
Bowel relief, pH↓
Absorption + permeability
-95% permeability; diarrhea
Gut barrier + immune
Cleansing + tolerance
Transit + symptoms
Acid suppression +93%
Bowel function / potassium
Diarrhea/ORS: stool -46%
Constipation relief + bowel frequency
−72pp constipation; +2 BM/week
Stool bulking + consistency
Permeability↓ ~70%
Diarrhea↓ / growth↑
Sepsis↓ / feeds↑
IBS symptoms/bloating +40%
UC remission/markers +53%
Mucositis pain/grade -0.84
Acid reflux ↓, pH ↑
Dyspepsia/pain ↓, pH ↑
Intake+digestibility
+15% intake
Milk yield+digestibility
Antioxidant↑, Digestive support
Gut enzymes↑, Oxidative balance
Stool frequency +1/week
Gas fermentation increased
Stool softening, constipation relief
Diarrhea -48%
Gut barrier -0.008
GI infections/feeds
Pain relief +36%
Motility suppression +25pp
Digestive recovery +flatus
Less symptoms, gas
Bowel motility +1 day
Digestion↑/illness↓
Gut emptying↑
Faster emptying, less nausea
Better bowel/IBS symptoms
Reduced bloating, constipation
H. pylori/ulcer: +clearance
Diarrhoea/IBS: -30% stools
Adenoma recurrence: -11%
Diarrhea risk -38%
Gut SCFAs up
Iron absorption up
Digestive support improved
GI protection + recovery
IBD symptom reduction
Less bloating/pain
UC relapse ↓16%
Digestive support: digestion +96.9%
Digestive support: bowel return −52%
Digestive lining protection
Swallowing safety +
GI symptoms -
Iron tolerance +
Digestive motility
Reflux/heartburn ↓
Digestive function ↑
Digestibility ↑, feed efficiency
Iron absorption ↓ 14%
GI symptoms/adhesions ↓
Barrier ↑; glutamine +
GI symptoms ↓; mucositis -53%
Digestive symptoms +44.5%
Inflammation/relapse 65%→26%
Gut inflammation/endotoxin ↓
Symptoms/QoL improved
Gut bacteria/SCFAs
+ favorable
Gastric emptying ~+96% delay
Digestive diges.+VFA
Symptoms/ulcer relapse
Mucositis -24%
Absorption ↓95%
Diarrhea/symptoms ↓
Gut inflammation ↓
TMAO ↑/↓ 250%
Gut microbes/SCFA
H. pylori clearance
+9–21 pp
Gut permeability/stool looseness +
Labor onset/VBAC +
Bowel prep/imaging mixed
Symptoms/remission +24%
Adverse effects +11
GIS, 43.3%
Pain/bloating, crying -124m
Anxiety/IBS severity, large
Bowel habit +1.75
Inflammation −60%
IBS symptoms -50%
Bowel recovery -1.9d
Diarrhea/IBS relief
Motility, metabolites, inflammation
Butyrate microbes, better digestion
Bile acids, cholesterol down
Digestion symptoms + relief
+44.7% IBS-D relief
Crohn’s remission, −67% TNF-α
IBS symptoms, −40%
Diarrhea recovery, −1.4 days
Bowel frequency +30%
Stool consistency, pain ↓
Gut bacteria, SCFAs ↑
UC symptom relief
Crohn’s CDAI −178
Ulcer healing ~100%
Diarrhea relief; +5.2h
GI symptoms improvement
Vomiting reduction
Bloating/pain ↓
Inflammation/markers ↓
SCFAs/bowel recovery ↑
Stool + fermentation
Bacteria + SCFAs
Glucose/insulin AUC ↓
Breath hydrogen ↑
Parasite clearance +91%
Gut damage, weight +11.6%
Dyspepsia relief ~40%
Gut flora shifts
IBS relief, QoL up
GERD/CINV symptom relief
Digestive support: histidine digestion
Digestive support: bowel relief
Digestive comfort + symptoms
Stool/diarrhea +
Reduced inflammation, better stool
ALA up; GI better
Bulk +33%
Transit -21%
Butyrate +60%
Akkermansia +19.3
Bowel symptoms +2.2/week
Fiber digestibility +
Bifidobacterium ↑
Stools +1/week
Absorption/retention +
Lesions/cholestasis +
Glucose control, fewer GI events
-11% post‑meal glucose
Gut transit +10h
Barrier/oxidative defense improved
Symptom intensity ↓
Fullness/bloating ↓
Response +12-20%
Remission/healing similar
Microbiota diversity ↑
Acetate +18%, bile acids ↓
Shorter diarrhea, +27% recovery
Fewer stools, shorter duration
IBS symptoms +13.8
Bowel frequency +1.3/week
Bleeding −1 week
Pain/irritation earlier
Diarrhea cure, frequency
Bloating symptoms improved
Colitis severity -0.83
Dyspepsia symptoms +78%
Gastric symptoms, H. pylori
Transit time, -21.5 LAP
Clinical: no change
Relapse: +8%
Saliva flow, dryness −
Choline, fat absorption +
Gastric acid/absorption +
Gut barrier/permeability
Metabolite & absorption shifts
Digestive relief +21.5%
IBS symptoms improved
GI symptoms reduced
Digestive: better digestibility
Digestive: faster acidification
Diarrhoea recovery +27%
Microbiome shift, SCFAs down
Acetaldehyde -32%
Nausea 0–6h -32%
Saliva support: +65%
Mucositis relief: -40pp
Gut anti-inflammatory shift
Stool frequency/pain, +5.24
Transit time/symptoms, ~-75%
Diarrhea shorter -13.6 hr
Pain relief
SCFAs + stool
Gas days -3.4
Symptoms/fatigue -20%
Quality of life +29%
Dryer stools, fewer diarrheas
Fecal DM +5%, diarrhea -30%
Hydrolysis unchanged
Absorption −6%
Excretion up
↓ flushing, GI AEs
no serious-AE rise
Cure +18%, less eggs
Mild adverse events
Bowel sounds +6.7h
Gas, stool +17h
Metaplasia +70%
Atypia +78%
↑ intake/growth; ↓E. coli
Digestibility shifts: +1-3% energy
Fiber digestibility changed -8%
Sore throat incidence ↓
Severity reduced
Vomiting reduced, 33%→9%
Vomiting severity lowered, 33%→6%
↓ glucose/insulin AUC
early glycemic spike -
↓ diarrhea symptoms
faster recovery
Leptin/NPY up; emptying improves
Antral residuals down
Growth, FCR improved
+8% WBC
Pain, diarrhea ↓
Fatigue/anorexia ↓
BW, villi, mucin +
Goblet cells, mucin +
Less dyspepsia symptoms
Better quality of life
HbA1c/AUC ↓
Gut microbes ↑
Stone expulsion unchanged
Pain meds -27.9%
Grade, bleeding, pain
36.4% normal grade
Beneficial flora +0.08
Fusobacteria -0.007
Lower dyspepsia, H. pylori
Significantly reduced severity
Disease activity ↓3.29
Quality of life similar
Heartburn/regurgitation ↓
Frequency/severity ↓
Nutrient absorption + weight
+0.22 kg/day
Liver/cholestasis protection
Dyspepsia relief, IL-1β ↓
No eradication, symptoms improved
GBEF +13.3%
Symptoms -3.8
GIS symptoms - p<0.05
Earlier relief vs placebo
Phosphorus/PTH drop
Ca×P decline
Dyspepsia relief: −81%
Microbiome shift: −72%
IBS relief −6.7
Microbiota minor shifts
Ulcers ↓; MDA ↓
SOD ↑
Digestive support: +10% efficiency
Digestive support: -900 kJ intake
Slower emptying +53%
Weight loss -5.1 kg
Slower gastric emptying
Fullness, -20 min
Rebound dyspepsia ↓55.6%
Reflux unchanged
Gut flora recovery +symptoms
Bifidobacteria +GLP-1 appetite
Stool frequency +42%
Firmer stools, less incomplete
Bowel emptying -0.47
Safer swallows −57%
Faster closure 0.380→0.306s
Gut balance unchanged
Bile-support genes up
GI regularity improved
Well-being up
No numeric change
BCAA uptake +14%
Gut barrier support
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