Proof.Fit

Digestive support

128 supplements analyzed and ranked by clinical evidence.

Supplements128

Supplement Evidence

Main Effects
Probiotics

IBS relief +27%

Liver/gut markers

Diarrhea/constipation

Strong
294215
Fiber

Constipation relief +78%

Stool/gas + SCFA

IBS symptoms -38

Strong
364513
Electrolytes

Motility/+BM frequency

Cleansing/tolerance +10%

Strong
656714
Digestive Enzymes

ALT/AST/GGT ↓

Digestion symptoms ↓ 70%

Strong
17077
Prebiotics

Bowel freq +38.5%

IBS symptoms βˆ’38.4pts

Stool softer/frequent

Strong
76915
Magnesium

Cleansing + better tolerated

Constipation + faster stools

Strong
183419
Butyrate

Acid/SCFA shifts, +10%

Bowel relief, pH↓

Strong
251515
Glutamine

Absorption + permeability

-95% permeability; diarrhea

Gut barrier + immune

Strong
48516
Senna

Cleansing + tolerance

Transit + symptoms

Strong
945
Potassium

Acid suppression +93%

Bowel function / potassium

Diarrhea/ORS: stool -46%

Strong
319717
Psyllium

Constipation relief + bowel frequency

βˆ’72pp constipation; +2 BM/week

Stool bulking + consistency

Strong
9712
Colostrum

Permeability↓ ~70%

Diarrhea↓ / growth↑

Sepsis↓ / feeds↑

Strong
22217
Curcumin

IBS symptoms/bloating +40%

UC remission/markers +53%

Mucositis pain/grade -0.84

Strong
36418
Sodium Bicarbonate

Acid reflux ↓, pH ↑

Dyspepsia/pain ↓, pH ↑

Strong
55810
Alfalfa

Intake+digestibility

+15% intake

Milk yield+digestibility

Strong
10811
Copper

Antioxidant↑, Digestive support

Gut enzymes↑, Oxidative balance

Strong
64718
Inulin

Stool frequency +1/week

Gas fermentation increased

Stool softening, constipation relief

Strong
29112
Lactoferrin

Diarrhea -48%

Gut barrier -0.008

GI infections/feeds

Strong
18815
Peppermint Oil

Pain relief +36%

Motility suppression +25pp

Strong
4110
Ginseng

Digestive recovery +flatus

Less symptoms, gas

Bowel motility +1 day

Strong
27118
Lysine

Digestion↑/illness↓

Gut emptying↑

Moderate
36818
Ginger

Faster emptying, less nausea

Better bowel/IBS symptoms

Reduced bloating, constipation

Moderate
23618
Berberine

H. pylori/ulcer: +clearance

Diarrhoea/IBS: -30% stools

Adenoma recurrence: -11%

Moderate
9916
Multivitamin

Diarrhea risk -38%

Gut SCFAs up

Iron absorption up

Moderate
45018
Phosphatidylcholine

Digestive support improved

GI protection + recovery

IBD symptom reduction

Moderate
29617
Turmeric

Less bloating/pain

UC relapse ↓16%

Moderate
19419
Bitter Orange

Digestive support: digestion +96.9%

Digestive support: bowel return βˆ’52%

Moderate
25113
Capsaicin

Digestive lining protection

Swallowing safety +

Moderate
24618
Glycine

GI symptoms -

Iron tolerance +

Digestive motility

Moderate
91317
Licorice

Reflux/heartburn ↓

Digestive function ↑

Moderate
7815
Chitosan

Digestibility ↑, feed efficiency

Iron absorption ↓ 14%

GI symptoms/adhesions ↓

Moderate
11618
Alanylglutamine

Barrier ↑; glutamine +

GI symptoms ↓; mucositis -53%

Moderate
5412
Collagen

Digestive symptoms +44.5%

Inflammation/relapse 65%β†’26%

Moderate
295114
Pomegranate

Gut inflammation/endotoxin ↓

Symptoms/QoL improved

Moderate
10416
Alcohol

Gut bacteria/SCFAs

+ favorable

Gastric emptying ~+96% delay

Moderate
232258
L-Methionine

Digestive diges.+VFA

Symptoms/ulcer relapse

Mucositis -24%

Moderate
34317
Activated Charcoal

Absorption ↓95%

Diarrhea/symptoms ↓

Moderate
1016
Choline

Gut inflammation ↓

TMAO ↑/↓ 250%

Moderate
76218
Cranberry

Gut microbes/SCFA

H. pylori clearance

+9–21 pp

Moderate
11014
Castor Oil

Gut permeability/stool looseness +

Labor onset/VBAC +

Bowel prep/imaging mixed

Moderate
354
Nicotine

Symptoms/remission +24%

Adverse effects +11

Moderate
286215
Lemon Balm

GIS, 43.3%

Pain/bloating, crying -124m

Anxiety/IBS severity, large

Moderate
20011
Aloe Vera

Bowel habit +1.75

Inflammation βˆ’60%

Moderate
11312
Fennel

IBS symptoms -50%

Bowel recovery -1.9d

Moderate
338
Cinnamon

Diarrhea/IBS relief

Motility, metabolites, inflammation

Moderate
6114
Black Walnut

Butyrate microbes, better digestion

Bile acids, cholesterol down

Moderate
8515
Wormwood

Digestion symptoms + relief

+44.7% IBS-D relief

Crohn’s remission, βˆ’67% TNF-Ξ±

Moderate
479
Boswellia

IBS symptoms, βˆ’40%

Diarrhea recovery, βˆ’1.4 days

Moderate
6014
Glucomannan

Bowel frequency +30%

Stool consistency, pain ↓

Gut bacteria, SCFAs ↑

Moderate
3212
Marijuana

UC symptom relief

Crohn’s CDAI βˆ’178

Ulcer healing ~100%

Moderate
117514
Chamomile

Diarrhea relief; +5.2h

GI symptoms improvement

Vomiting reduction

Moderate
7817
Beta-Glucans

Bloating/pain ↓

Inflammation/markers ↓

SCFAs/bowel recovery ↑

Moderate
16818
Barley Grass

Stool + fermentation

Bacteria + SCFAs

Moderate
5915
Salacia Reticulata

Glucose/insulin AUC ↓

Breath hydrogen ↑

Moderate
1110
Artemisia Annua

Parasite clearance +91%

Gut damage, weight +11.6%

Moderate
159
Artichoke Extract

Dyspepsia relief ~40%

Gut flora shifts

Moderate
2513
Evodia Rutaecarpa

IBS relief, QoL up

GERD/CINV symptom relief

Moderate
86
L-Histidine

Digestive support: histidine digestion

Digestive support: bowel relief

Moderate
15916
Pea Protein

Digestive comfort + symptoms

Stool/diarrhea +

Moderate
4514
Flaxseed Oil

Reduced inflammation, better stool

ALA up; GI better

Moderate
11617
Lupin

Bulk +33%

Transit -21%

Butyrate +60%

Moderate
20312
Akkermansia muciniphila

Akkermansia +19.3

Bowel symptoms +2.2/week

Weak
3614
Chicory Root

Fiber digestibility +

Bifidobacterium ↑

Stools +1/week

Weak
89
Manganese

Absorption/retention +

Lesions/cholestasis +

Weak
8714
Mulberry

Glucose control, fewer GI events

-11% post‑meal glucose

Weak
4912
Sage

Gut transit +10h

Barrier/oxidative defense improved

Weak
52116
Charcoal

Symptom intensity ↓

Fullness/bloating ↓

Weak
1017
Andrographis Paniculata

Response +12-20%

Remission/healing similar

Weak
169
Avocado

Microbiota diversity ↑

Acetate +18%, bile acids ↓

Weak
4716
Apple Pectin

Shorter diarrhea, +27% recovery

Fewer stools, shorter duration

Weak
74
Acacia Fiber

IBS symptoms +13.8

Bowel frequency +1.3/week

Weak
156
Gotu Kola

Bleeding βˆ’1 week

Pain/irritation earlier

Weak
3814
Black Pepper

Diarrhea cure, frequency

Bloating symptoms improved

Weak
3713
Saffron

Colitis severity -0.83

Dyspepsia symptoms +78%

Weak
10718
Garlic

Gastric symptoms, H. pylori

Transit time, -21.5 LAP

Weak
15317
Myrrh

Clinical: no change

Relapse: +8%

Weak
279
Betaine

Saliva flow, dryness βˆ’

Choline, fat absorption +

Gastric acid/absorption +

Weak
11816
Quercetin

Gut barrier/permeability

Metabolite & absorption shifts

Weak
14219
Ellagic Acid

Digestive relief +21.5%

IBS symptoms improved

GI symptoms reduced

Weak
2515
Betaine HCL

Digestive: better digestibility

Digestive: faster acidification

Weak
1206
Arabinogalactan

Diarrhoea recovery +27%

Microbiome shift, SCFAs down

Weak
126
Noni

Acetaldehyde -32%

Nausea 0–6h -32%

Weak
76
Dendrobium

Saliva support: +65%

Mucositis relief: -40pp

Gut anti-inflammatory shift

Weak
36
Jujube

Stool frequency/pain, +5.24

Transit time/symptoms, ~-75%

Weak
1813
Guava Leaf

Diarrhea shorter -13.6 hr

Pain relief

Weak
45
Rose Hip

SCFAs + stool

Gas days -3.4

Weak
5210
Agaricus Blazei

Symptoms/fatigue -20%

Quality of life +29%

Weak
78
Dragon's Blood

Dryer stools, fewer diarrheas

Fecal DM +5%, diarrhea -30%

Weak
55
Phytosterols

Hydrolysis unchanged

Absorption βˆ’6%

Excretion up

Weak
30617
Niacin

↓ flushing, GI AEs

no serious-AE rise

Weak
30813
Artemisinin

Cure +18%, less eggs

Mild adverse events

Weak
83912
Skullcap

Bowel sounds +6.7h

Gas, stool +17h

Weak
2511
Dandelion

Metaplasia +70%

Atypia +78%

Weak
57
Oat Straw

↑ intake/growth; ↓E. coli

Digestibility shifts: +1-3% energy

Fiber digestibility changed -8%

Weak
13
Pantothenic Acid

Sore throat incidence ↓

Severity reduced

Weak
585
Vitamin B1

Vomiting reduced, 33%β†’9%

Vomiting severity lowered, 33%β†’6%

Weak
26717
Wild Yam

↓ glucose/insulin AUC

early glycemic spike -

Weak
1111
Hawthorn

↓ diarrhea symptoms

faster recovery

Weak
16016
Sea Buckthorn

Leptin/NPY up; emptying improves

Antral residuals down

Weak
217
Bee Pollen

Growth, FCR improved

+8% WBC

Weak
25
Coptis

Pain, diarrhea ↓

Fatigue/anorexia ↓

Weak
913
Moringa

BW, villi, mucin +

Goblet cells, mucin +

Weak
2512
Cilantro

Less dyspepsia symptoms

Better quality of life

Weak
104
White Kidney Bean

HbA1c/AUC ↓

Gut microbes ↑

Weak
510
Cramp Bark

Stone expulsion unchanged

Pain meds -27.9%

Weak
12
Propolis

Grade, bleeding, pain

36.4% normal grade

Weak
9516
Corydalis

Beneficial flora +0.08

Fusobacteria -0.007

Weak
116
Black Seed Oil

Lower dyspepsia, H. pylori

Significantly reduced severity

Weak
4915
Bromelain

Disease activity ↓3.29

Quality of life similar

Weak
4510
Amla

Heartburn/regurgitation ↓

Frequency/severity ↓

Weak
2913
MCT Oil

Nutrient absorption + weight

+0.22 kg/day

Liver/cholestasis protection

Weak
5311
Clove

Dyspepsia relief, IL-1Ξ² ↓

No eradication, symptoms improved

Weak
338
TUDCA

GBEF +13.3%

Symptoms -3.8

Weak
129
Milk Thistle

GIS symptoms - p<0.05

Earlier relief vs placebo

Weak
5114
Vitamin B3

Phosphorus/PTH drop

CaΓ—P decline

Weak
55916
Asafoetida

Dyspepsia relief: βˆ’81%

Microbiome shift: βˆ’72%

Weak
39
D-Limonene

IBS relief βˆ’6.7

Microbiota minor shifts

Weak
135
Royal Jelly

Ulcers ↓; MDA ↓

SOD ↑

Weak
2712
Hops

Digestive support: +10% efficiency

Digestive support: -900 kJ intake

Weak
489
Damiana

Slower emptying +53%

Weight loss -5.1 kg

Weak
65
Yerba Mate

Slower gastric emptying

Fullness, -20 min

Weak
139
Spirulina

Rebound dyspepsia ↓55.6%

Reflux unchanged

Weak
5518
Kelp

Gut flora recovery +symptoms

Bifidobacteria +GLP-1 appetite

Weak
4812
Kombucha

Stool frequency +42%

Firmer stools, less incomplete

Bowel emptying -0.47

Weak
36
Piperine

Safer swallows βˆ’57%

Faster closure 0.380β†’0.306s

Weak
5118
Slippery Elm

Gut balance unchanged

Bile-support genes up

Weak
33
Goji Berry

GI regularity improved

Well-being up

No numeric change

Weak
1917
Astragalus

BCAA uptake +14%

Gut barrier support

Weak
14917