Digestive support
128 supplements analyzed and ranked by clinical evidence.
Supplement Evidence
IBS relief +27%
Liver/gut markers
Diarrhea/constipation
Constipation relief +78%
Stool/gas + SCFA
IBS symptoms -38
Motility/+BM frequency
Cleansing/tolerance +10%
ALT/AST/GGT β
Digestion symptoms β 70%
Bowel freq +38.5%
IBS symptoms β38.4pts
Stool softer/frequent
Cleansing + better tolerated
Constipation + faster stools
Acid/SCFA shifts, +10%
Bowel relief, pHβ
Absorption + permeability
-95% permeability; diarrhea
Gut barrier + immune
Cleansing + tolerance
Transit + symptoms
Acid suppression +93%
Bowel function / potassium
Diarrhea/ORS: stool -46%
Constipation relief + bowel frequency
β72pp constipation; +2 BM/week
Stool bulking + consistency
Permeabilityβ ~70%
Diarrheaβ / growthβ
Sepsisβ / feedsβ
IBS symptoms/bloating +40%
UC remission/markers +53%
Mucositis pain/grade -0.84
Acid reflux β, pH β
Dyspepsia/pain β, pH β
Intake+digestibility
+15% intake
Milk yield+digestibility
Antioxidantβ, Digestive support
Gut enzymesβ, Oxidative balance
Stool frequency +1/week
Gas fermentation increased
Stool softening, constipation relief
Diarrhea -48%
Gut barrier -0.008
GI infections/feeds
Pain relief +36%
Motility suppression +25pp
Digestive recovery +flatus
Less symptoms, gas
Bowel motility +1 day
Digestionβ/illnessβ
Gut emptyingβ
Faster emptying, less nausea
Better bowel/IBS symptoms
Reduced bloating, constipation
H. pylori/ulcer: +clearance
Diarrhoea/IBS: -30% stools
Adenoma recurrence: -11%
Diarrhea risk -38%
Gut SCFAs up
Iron absorption up
Digestive support improved
GI protection + recovery
IBD symptom reduction
Less bloating/pain
UC relapse β16%
Digestive support: digestion +96.9%
Digestive support: bowel return β52%
Digestive lining protection
Swallowing safety +
GI symptoms -
Iron tolerance +
Digestive motility
Reflux/heartburn β
Digestive function β
Digestibility β, feed efficiency
Iron absorption β 14%
GI symptoms/adhesions β
Barrier β; glutamine +
GI symptoms β; mucositis -53%
Digestive symptoms +44.5%
Inflammation/relapse 65%β26%
Gut inflammation/endotoxin β
Symptoms/QoL improved
Gut bacteria/SCFAs
+ favorable
Gastric emptying ~+96% delay
Digestive diges.+VFA
Symptoms/ulcer relapse
Mucositis -24%
Absorption β95%
Diarrhea/symptoms β
Gut inflammation β
TMAO β/β 250%
Gut microbes/SCFA
H. pylori clearance
+9β21 pp
Gut permeability/stool looseness +
Labor onset/VBAC +
Bowel prep/imaging mixed
Symptoms/remission +24%
Adverse effects +11
GIS, 43.3%
Pain/bloating, crying -124m
Anxiety/IBS severity, large
Bowel habit +1.75
Inflammation β60%
IBS symptoms -50%
Bowel recovery -1.9d
Diarrhea/IBS relief
Motility, metabolites, inflammation
Butyrate microbes, better digestion
Bile acids, cholesterol down
Digestion symptoms + relief
+44.7% IBS-D relief
Crohnβs remission, β67% TNF-Ξ±
IBS symptoms, β40%
Diarrhea recovery, β1.4 days
Bowel frequency +30%
Stool consistency, pain β
Gut bacteria, SCFAs β
UC symptom relief
Crohnβs CDAI β178
Ulcer healing ~100%
Diarrhea relief; +5.2h
GI symptoms improvement
Vomiting reduction
Bloating/pain β
Inflammation/markers β
SCFAs/bowel recovery β
Stool + fermentation
Bacteria + SCFAs
Glucose/insulin AUC β
Breath hydrogen β
Parasite clearance +91%
Gut damage, weight +11.6%
Dyspepsia relief ~40%
Gut flora shifts
IBS relief, QoL up
GERD/CINV symptom relief
Digestive support: histidine digestion
Digestive support: bowel relief
Digestive comfort + symptoms
Stool/diarrhea +
Reduced inflammation, better stool
ALA up; GI better
Bulk +33%
Transit -21%
Butyrate +60%
Akkermansia +19.3
Bowel symptoms +2.2/week
Fiber digestibility +
Bifidobacterium β
Stools +1/week
Absorption/retention +
Lesions/cholestasis +
Glucose control, fewer GI events
-11% postβmeal glucose
Gut transit +10h
Barrier/oxidative defense improved
Symptom intensity β
Fullness/bloating β
Response +12-20%
Remission/healing similar
Microbiota diversity β
Acetate +18%, bile acids β
Shorter diarrhea, +27% recovery
Fewer stools, shorter duration
IBS symptoms +13.8
Bowel frequency +1.3/week
Bleeding β1 week
Pain/irritation earlier
Diarrhea cure, frequency
Bloating symptoms improved
Colitis severity -0.83
Dyspepsia symptoms +78%
Gastric symptoms, H. pylori
Transit time, -21.5 LAP
Clinical: no change
Relapse: +8%
Saliva flow, dryness β
Choline, fat absorption +
Gastric acid/absorption +
Gut barrier/permeability
Metabolite & absorption shifts
Digestive relief +21.5%
IBS symptoms improved
GI symptoms reduced
Digestive: better digestibility
Digestive: faster acidification
Diarrhoea recovery +27%
Microbiome shift, SCFAs down
Acetaldehyde -32%
Nausea 0β6h -32%
Saliva support: +65%
Mucositis relief: -40pp
Gut anti-inflammatory shift
Stool frequency/pain, +5.24
Transit time/symptoms, ~-75%
Diarrhea shorter -13.6 hr
Pain relief
SCFAs + stool
Gas days -3.4
Symptoms/fatigue -20%
Quality of life +29%
Dryer stools, fewer diarrheas
Fecal DM +5%, diarrhea -30%
Hydrolysis unchanged
Absorption β6%
Excretion up
β flushing, GI AEs
no serious-AE rise
Cure +18%, less eggs
Mild adverse events
Bowel sounds +6.7h
Gas, stool +17h
Metaplasia +70%
Atypia +78%
β intake/growth; βE. coli
Digestibility shifts: +1-3% energy
Fiber digestibility changed -8%
Sore throat incidence β
Severity reduced
Vomiting reduced, 33%β9%
Vomiting severity lowered, 33%β6%
β glucose/insulin AUC
early glycemic spike -
β diarrhea symptoms
faster recovery
Leptin/NPY up; emptying improves
Antral residuals down
Growth, FCR improved
+8% WBC
Pain, diarrhea β
Fatigue/anorexia β
BW, villi, mucin +
Goblet cells, mucin +
Less dyspepsia symptoms
Better quality of life
HbA1c/AUC β
Gut microbes β
Stone expulsion unchanged
Pain meds -27.9%
Grade, bleeding, pain
36.4% normal grade
Beneficial flora +0.08
Fusobacteria -0.007
Lower dyspepsia, H. pylori
Significantly reduced severity
Disease activity β3.29
Quality of life similar
Heartburn/regurgitation β
Frequency/severity β
Nutrient absorption + weight
+0.22 kg/day
Liver/cholestasis protection
Dyspepsia relief, IL-1Ξ² β
No eradication, symptoms improved
GBEF +13.3%
Symptoms -3.8
GIS symptoms - p<0.05
Earlier relief vs placebo
Phosphorus/PTH drop
CaΓP decline
Dyspepsia relief: β81%
Microbiome shift: β72%
IBS relief β6.7
Microbiota minor shifts
Ulcers β; MDA β
SOD β
Digestive support: +10% efficiency
Digestive support: -900 kJ intake
Slower emptying +53%
Weight loss -5.1 kg
Slower gastric emptying
Fullness, -20 min
Rebound dyspepsia β55.6%
Reflux unchanged
Gut flora recovery +symptoms
Bifidobacteria +GLP-1 appetite
Stool frequency +42%
Firmer stools, less incomplete
Bowel emptying -0.47
Safer swallows β57%
Faster closure 0.380β0.306s
Gut balance unchanged
Bile-support genes up
GI regularity improved
Well-being up
No numeric change
BCAA uptake +14%
Gut barrier support