Nicotine

Craving↓; anxiety↓

Stress/anxiety↑; craving↑

Reward↑ confidence↑

Quit rates +10%

Stimulant/CV ↑, mood +

Craving/withdrawal ↓, mood +

Memory/attention +10%

Craving/withdrawal ↓

Task speed ↑

Alertness+RT

Craving+HR

Weight gain: +3–5 kg

Nicotine replacement: less gain

Nicotine ↓ hunger; +1.7 kg

Nicotine gum/patch ↓ weight

RT+memory up

Flight/attention +0.8

Craving down, RT up

Memory/attention +

Reaction time -

Memory improves

+1.6 days abstinence

Acute pain ↓; opioids ↓

Withdrawal pain ↑; hyperalgesia ↑

Central pain unchanged

Symptoms/remission +24%

Adverse effects +11

↓ fatigue, ↑ arousal

+HR/BP, +thermogenesis

Cognition/attention + faster RT

Eye-motor/sensorimotor gating +PPI

Cognition/EEG: better memory, attention

Seizures: -1.64/day, near-zero