Proof.Fit

Weight management

115 supplements analyzed and ranked by clinical evidence.

Supplements115

Supplement Evidence

Main Effects
Fiber

Weight loss -7.3%

Waist/fat loss -2.8 cm

Strong
364513
Vitamin D

Fat loss +weight

Glucose/insulin ↓

Strong
435919
Fish Oil

Less waist/fat

+1.9kg weight gain

Lower insulin/TG

Strong
290520
Probiotics

Body weight/waist ↓

Fat oxidation ↑

Strong
294215
Phenylethylamine

Weight loss +3.4 kg

Weight loss βˆ’14.4%

Blood pressure ↓

Strong
357511
Omega-3 Fatty Acids

Waist/fat ↓

Visceral fat -53%

Weight loss +7.8kg

Strong
288519
Prebiotics

Weight loss: -5kg

Waist/fat loss: -2.6cm

Strong
76915
Nicotine

Weight gain: +3–5 kg

Nicotine replacement: less gain

Strong
286215
Digestive Enzymes

Weight loss/body fat βˆ’5.9kg

Steatorrhea ↓ absorption

Strong
17077
Whey Protein

Satiety intake ↓

Body fat/lean mass

+10% intake drop

Strong
66217
Essential Amino Acids

Fat loss/satiety + lipolysis

Weight gain/muscle preservation

Strong
262919
L-Carnitine

Weight/fat loss

βˆ’4.6 kg

Improved satiety/metabolism

Strong
46519
Conjugated Linoleic Acid

Lower fat mass

βˆ’8.7% fat mass

Slight muscle gain

Strong
11014
Bitter Orange

Weight/BMI ↓

Waist/fat ↓

βˆ’5.2 kg

Strong
25113
Ephedrine

More weight loss

Fat/lean shifts

~+3.4 kg

Strong
56213
Carnitine

Weight loss: +23.7% vs +19.6%

Fat/muscle shift

Metabolic support

Strong
47518
Casein

Satiety/intake ↓

Weight loss/maintenance ↑

Body fat ↓

Strong
35215
Curcumin

Weight loss, better waist/BMI

Fat-loss, better glucose

Strong
36418
Colostrum

Growth +weight gain

Stunting/weight indices

Mortality ↓30%

Strong
22217
Green Tea Extract

Weight loss & fat ↓

Energy use +3-4%

Strong
24417
Inulin

Weight loss βˆ’7.3%

Less food intake

Lower body fat

Strong
29112
Berberine

Weight loss, fat -3.5kg

Glycemia/lipids, less weight

Fat loss, waist/BMI

Moderate
9916
Beef Protein

Weight loss +5.6–6 kg

Fullness up, intake down

Moderate
24912
Akkermansia muciniphila

Weight loss + insulin

Less appetite + fat

Moderate
3614
Chromium

Weight loss, fat sparing

-3.6 kg

Reduced intake, cravings

Moderate
43411
Butyrate

Weight loss +BMI

Fat loss +WC

Improved glucose/butyrate

Moderate
251515
Black Walnut

Neutral weight: +0.4 kg

Lower intake: -97 kcal

Moderate
8515
Alpha-Lipoic Acid

Weight loss; BMI↓

Weight loss; βˆ’2.1%

Weight maintenance; waist↓

Moderate
21217
Spirulina

↓ weight/fat

↓ appetite/inflammation

Moderate
5518
Inositol

Weight↓ insulin/androgens

Child obesity↓ +49%

Moderate
27017
Turmeric

Weight ↓, leptin↓

Weight ↓, BMI↓

Moderate
19419
MCT Oil

Fat loss/EE +1.7kg

Fullness/intake -34%

Moderate
5311
Chitosan

Weight loss βˆ’3 to βˆ’6 kg

Waist/body fat ↓

BMI βˆ’1 to βˆ’2

Moderate
11618
Saffron

Weight ↓, glucose/lipids

Weight ↓, appetite↓

Moderate
10718
Glycine

Lower diabetes risk

Weight loss +3.5kg

Improved weight maintenance

Moderate
91317
Gamboge

Weight -5kg, waist -10cm

Fat loss, weight loss

Moderate
2710
Chlorogenic Acid

Weight/fat loss: βˆ’2.2 kg

Waist/VFA reduction

Weight loss: βˆ’5.4 kg

Moderate
4616
Isoleucine

↓BCAAs, ↑weight loss

↓hunger, ↓intake

↑satiety hormones

Moderate
8613
Epigallocatechin Gallate

Weight gain prevented

βˆ’2.5 kg

Fat oxidation up +4%

Moderate
10919
Soy Isoflavones

↓ fat mass/weight

↓ insulin resistance

Moderate
35516
Garlic

↓BMI/weight

↓waist circumference

Moderate
15317
Glucomannan

Weight loss +7.3%

Fat loss βˆ’19.4%

Moderate
3212
Black Seed Oil

Weight/BMI ↓ ~6%

Waist ↓; blood sugar ↓

Moderate
4915
Barley Grass

↓ appetite/intake

↓ waist/fat

↓ glucose/LDL

Moderate
5915
Alfalfa

Fat ↓

Intake/gain ↑

Moderate
10811
DHEA

Weight/fat loss βˆ’2.8 kg

Waist/BMI stabilized

Moderate
48716
Anthocyanins

Fat oxidation +25-29%

Body fat/weight loss

Insulin/lipid improvements

Moderate
13119
Phytosterols

Weight loss + cholesterol

Weight gain +2.8 kg

Waist βˆ’3.8 cm

Moderate
30617
Capsaicin

+fat oxidation

-energy intake

-weight/fat

Moderate
24618
Allulose

Weight loss, lower BMI

Better glucose control

Moderate
54
Cinnamon

Weight βˆ’3.0 kg

BMI/body fat↓

Moderate
6114
Pomegranate

Weight loss -5.5 kg

BMI/waist decrease

Moderate
10416
Psyllium

Weight -7.3%

+2.7 kg

Moderate
9712
Bergamot

Weight loss -14.8%

Body mass -4.2 kg

Moderate
3515
Gymnema Sylvestre

Sugar intake ↓42%

Body weight ↓3.4 kg

Moderate
106
Hibiscus

Weight loss, less appetite

~3.7 kg loss

More satiety, lower intake

Moderate
3413
Betaine

BMI/body fat ↓

Fat loss markers ↓

Liver enzymes ↓

Moderate
11816
Resveratrol

BMI/weight -3.9 kg

Weight loss +6.82 kg

Moderate
17619
Acacia Fiber

Weight loss -0.8 to 1.5 kg

BMI/body fat ↓ modestly

Lower intake, more satiety

Moderate
156
Jiaogulan

Weight/fat ↓

BMI βˆ’

Weight βˆ’0.96 kg

Moderate
88
Piperine

Weight loss +5.85 kg

Weight maintenance +30%

Moderate
5118
Mangosteen

Weight βˆ’5kg

Waist βˆ’12cm

Moderate
1510
Ashwagandha

Body fat -3.47%

BMI -3.31 kg/mΒ²

Strength gains +46 kg

Moderate
5018
Guarana

Weight/fat loss βˆ’4.0kg

Reduced intake ~17%

Moderate
169
Caralluma Fimbriata

Hunger/waist ↓

Weight/BMI βˆ’1.7 kg

Calories βˆ’229/day

Moderate
45
Vitamin B7

Growth + lesions

+0.180 mg/kg

Weak
7310
Lactoferrin

Growth efficiency +14%

Weight/BMI -2.5kg

Weak
18815
Charcoal

GI absorption blockade

Weight neutral

Weak
1017
Lupin

Satiety βˆ’488 kJ

Weight loss βˆ’7.4 kg

Weak
20312
Cissus Quadrangularis

Weight/body fat -8%

GLP-1/ DPP-4 +42

Weak
74
Fucoxanthin

Weight βˆ’5.5 kg

Weight βˆ’1.4 kg

No extra loss

Weak
512
Cornelian Cherry

Weight/waist ↓

No exact %

Weak
57
Ecklonia Cava

Body fat down

Cholesterol improved

Weak
36
Garcinia Cambogia

Weight: -4.7% / -2.3kg

Responders: 23 vs 1

Weak
103
White Kidney Bean

Weight loss, waist ↓

Fat loss, BMI ↓

Weak
510
Damiana

Slower emptying, βˆ’5.1 kg

βˆ’17% intake, less hunger

Weak
65
Kelp

Body mass -5.0%

Waist -5.9%

Weak
4812
Yerba Mate

Fat burning +23–28%

Lower intake -17%

Body fat/WHR down

Weak
139
Yacon

Weight loss + insulin↓

Satiety/ bowel ↑

Weak
44
Pea Protein

Intake ↓ ~12%

Satiety/glucose ↑

Meal intake ↓ 126 kcal

Weak
4514
Senna

Bowel cleanliness unchanged

No intolerance reported

Weak
945
Acetyl-L-Carnitine

Insulin resistance improved

Adiponectin up, regularity +84%

Weak
9017
Coptis

Weight loss -1.7 kg

Insulin resistance improved

Weak
913
Avocado

VS ratio ↓ women

VAT βˆ’32.9 g

Weak
4716
Black Garlic

Mediterranean +1.6

Calories -195.5

Spices +1.9

Weak
75
Bee Pollen

Weight gain, FCR improved

WBC +8%

Weak
25
Tribulus Terrestris

Glucose, LDL ↓

Cholesterol ↓

Weak
239
Black Ginger

Triglycerides βˆ’31%

Glucose/cholesterol modestly lower

Weak
86
Black Pepper

Appetite -hunger; satiety +

Insulin resistance -1.1, glucose -7

Weak
3713
Chia Seeds

Weight -1.9 kg

Waist -3.5 cm

Weak
118
Bitter Melon

Pain relief, -weight

Glucose drop, less analgesics

Weak
107
Red Yeast Rice

Weight -5.5%

Triglycerides -29%

Weak
6814
Desiccated Thyroid

Weight loss -3 lb

No symptom change

Weak
97
Grains of Paradise

Energy use↑, fat↓ +18.6%

Weight↓, belly fat↓ -4.1kg

Weak
17
Green Coffee Extract

Waist βˆ’2.4 cm

Weight/fat ↓

Weak
148
Artichoke Extract

Lipid improvement, weight βˆ’1.2kg

Visceral fat βˆ’107g

Weak
2513
DIM

Body fat ↓

EMUR unchanged

Weak
2645
Evodia Rutaecarpa

Fat/weight loss: βˆ’2.7kg

Body fat drop: βˆ’1.6kg

Weak
86
Jujube

Lower glycaemia

Waist -4 cm

Weak
1813
Exogenous Ketones

↓ glucose, NEFA

↓ hunger, ghrelin

Weak
175
Gamma Oryzanol

BMI/waist down

LDL-C -0.86

Weak
148
Terminalia Arjuna

BMI, lipids, BP down

slight edge over control

Weak
3315
Chlorella

Fat mass ↓

Performance +

Weak
1812
Naringenin

BMI, visceral fat ↓

Lipid ratios ↓

Weak
166
Vanadium

Better glucose, weight, ~0.9 mg V/day

Lower insulin resistance, gene expression

Weak
116
Amla

Visceral fat/waist ↓

Muscle mass ↑

Weak
2913
Salacia Reticulata

Weight loss βˆ’5.3 kg

Body fat βˆ’4.5%

Weak
1110
Chlorophyll

Satiety, hypoglycaemia

Weight loss +1.5kg

Weak
1310
Beta-Sitosterol

Weight gain +2.8 kg

No culture change

Weak
6711
Cranberry

FFM↑, FM↓

PDE↓, DNA damage↓

Weak
11014
Flaxseed Oil

Weight stable vs +4%

Omega-3 up

Weak
11617
Matcha

Fat burn +13–24%

Weight loss -10.6 kg

Weak
1113
Ginseng

BMI βˆ’0.61

PBG/IR/CRP down

Weak
27118
Forskolin

Fat loss, +16.8% free T

Lower body fat, more free T

Weak
137
Moringa

BMI ↓

BMI +

Weak
2512