Proof.Fit

Skin health

95 supplements analyzed and ranked by clinical evidence.

Supplements95

Supplement Evidence

Main Effects
Vitamin D

Psoriasis control; +70% PASI

Vitiligo repigmentation; +35%

Wound healing; -88%

Strong
435919
Iodine

Infection↓; PI -13%

Healing↑; 3 days

Strong
160217
Zinc

Barrier/healing +7pp

Acne/dermatitis reduced

-35 days wound

Strong
180417
Vitamin A

Thicker, less pigmented skin

Less irritation, better tolerance

Strong
130714
Vitamin B3

Pigment/texture +MASI

Barrier/hydration -TEWL

Strong
55916
Vitamin C

Pigment/brightening +1.3

Wound/scar healing improved

Anti-wrinkle/hydration +28%

Strong
151318
Vitamin E

Photoprotection, antioxidant

Wound healing, scars

Strong
181517
Fish Oil

Acne inflammation ↓

Wound healing ↑

Strong
290520
Omega-3 Fatty Acids

Hydration↑, TEWL↓

Eczema/psoriasis↓, itch↓

PUFA↑, inflammation↓

Strong
288519
Zeaxanthin

Eye/retina: MPOD +15%

Skin carotenoids: +42%

Strong
1567
Selenium

Wound healing +50%

Skin inflammation +function

Cancer risk +17%

Moderate
69617
Chitosan

Healing + infection↓

Pain/swelling↓, healing↑

Skin redness↓, hydration↑

Moderate
11618
Tea Tree Oil

Demodex/OSDI −5.5

Hand microbes −10%

Athlete’s foot +72%

Moderate
479
Vitamin B5

Hydration/barrier +TEWL

Redness/inflammation ↓

Healing/repair faster

Moderate
708
Beta-Carotene

Antioxidant photoprotection + skin redness

Carotenoids/pigmentation +10-67%

Moderate
80713
Glycine

Skin hydration/elasticity

+26%, +5.7

Pigmentation/redness/wrinkles:-19.5%

Moderate
91317
Turmeric

Wound healing +60%

Pruritus/psoriasis improved

Hydration up, TEWL down

Moderate
19419
Copper

Wrinkles/photoaging; +31% elasticity

Infection prevention; -29% ATIs

Moderate
64718
N-Acetyl Cysteine

Skin healing improved

Inflammation/oxidation reduced

Moderate
62317
Quercetin

Healing + elasticity

Acne + barrier

Wrinkles -7%

Moderate
14219
Lysine

Collagen +30g

Healing +34%

Moderate
36818
Phytosterols

Less itch, pain

Faster healing, more clearance

Moderate
30617
Magnesium

Skin aging/redness ↓

Eczema/psoriasis barrier ↑

Ulcers/swelling/bruising ↓

Moderate
183419
Spermidine

Hair growth ↑

AK lesions −24%

Skin polyamines ↓

Moderate
2611
Phenylalanine

Lightening/depigmenting skin

+10–13%,−18–21%

Repigmenting vitiligo skin

Moderate
110316
Vitamin B12

Better skin severity

Less itching/pain

Moderate
95115
Sodium Bicarbonate

Less pain, more satisfaction

+12 min sleep

Faster skin prep

Moderate
55810
Ellagic Acid

Collagen +37-41%

Pigment/lightening improvement

Wrinkle reduction

Moderate
2515
Epigallocatechin Gallate

Inflammation/lesions ↓; −22% RID

Pigmentation/scar repair ↑

Redness/angiogenesis ↓; −14.6% HIF-1α

Moderate
10919
Garlic

Fungal cure +2%

Microcirculation +22%

Moderate
15317
Arachidonic Acid

Inflammation ↓, +30%

Skin symptoms ↓

AA-mediated irritation ↓

Moderate
59519
Pine Bark Extract

Elasticity/texture +9%

Pigment/spot reduction

Moderate
5318
Danshen

Scar healing +91.4%

Flap ischemia/necrosis ↓

Mouth opening +5.5 mm

Moderate
12117
Lecithin

Barrier/pigment ↓

Inflammation/pain ↓

Moderate
14213
Lycopene

Skin carotenoids +31-46%

UV redness -25-48%

Moderate
19618
DHEA

Collagen/AR ↑

Oil/brightness +

Moderate
48716
Soy Isoflavones

Wrinkles ↓, +10%

Hydration/pigment improved

Collagen ↑

Moderate
35516
Alpha-Lipoic Acid

Repigmentation/healing +90%

Photoageing/roughness -50.8%

Moderate
21217
Milk Thistle

Less dermatitis/mucositis

Better wound healing

Moderate
5114
Astaxanthin

Wrinkles/elasticity/hydration improved

UV resistance +5 mJ/cm2

Moderate
5617
Beta-Glucans

Immune/recurrence: improved

Hydration/repair: +68.2%

Moderate
16818
Niacin

Barrier +25%/−20%

Flushing −50%

Itch −28%

Moderate
30813
Vitamin K

Bruising severity -20%

Rash severity women

Moderate
66214
Amla

Lightening, similar to HQ

Hydration/elasticity: +10-26%

Moderate
2913
Inositol

Insulin/androgens ↓ 62%/55%

Skin barrier ↑ hydration 50%

Moderate
27017
Vitamin B6

PPE/HFS ↓ incidence

QoL/pain improved

Moderate
54417
Mulberry

Vascularity/pigment ↓

MASI −1.2

Wrinkles −17%

Moderate
4912
Chlorogenic Acid

Hydration↑, TEWL↓

Pigment/erythema↓

Pigment area↓ (~45%)

Weak
4616
Evening Primrose Oil

Barrier + hydration

DGLA / symptoms

Weak
4810
Resveratrol

Hydration, TEWL

Wound closure, TNF

Redness, melanin, hydration

Weak
17619
Rutin

Irritation/redness ↓

Wrinkles/elasticity ↑

Weak
8613
Sage

Healing & pain: ~6.7d

Redness/inflammation: reduced

Weak
52116
Vitamin B2

Angular stomatitis 30.4%→0%

Acne lesions ↓; less irritation

Weak
40015
Althaea Officinalis

Dry mouth, QoL

VVC symptoms, better

Weak
610
White Mulberry

Pigmentation −12%

Wrinkles/smoothness +14%

Weak
1210
Berberine

Pain/inflammation ↓

Ulcers healed faster

Healing score, pain ↓

Weak
9916
Artemisinin

Acne severity ↓

Itch relief 82%

Weak
83912
Jujube

Hyperpigmentation ↓0.56

Acne lesions ↓

Acne severity ↓

Weak
1813
Piperine

Vitiligo repigmentation + irritation

Hair regrowth, SALT ↓

Weak
5118
Black Seed Oil

Pain relief, healing faster

Burning/lesions ↓ ~90%

Weak
4915
Olive Leaf Extract

Faster healing, -0.8 days

Less pain, itching

Weak
1713
Alpha-Ketoglutarate

Healing faster: -30d

Less breakdown markers

Better nitrogen balance

Weak
6910
Lutein

↑ Carotenoids; ↓ UV erythema

↓ UV genes; ↑ protection

Weak
2588
Chicory Root

Barrier, texture improved

Radiodermatitis delayed

Weak
89
Multivitamin

Texture: no change

Pigment: ↓ melanin

Carotenoids: +27%

Weak
45018
Ursolic Acid

Brightening: MI −10.2%

Hydration/elasticity: R2 +28%

Weak
56
Cilantro

Redness ↓; tinea signs ↓

UV erythema, fungal infection

Weak
104
Shilajit

Collagen synthesis +94-165%

Microperfusion, collagen genes

Weak
68
Ginger

Itch −55%; eczema

Wrinkles/pigment/redness −20–30%

Weak
23618
Manganese

Laser downtime/erythema ↓

Mucositis 1.5d vs 19d

Weak
8714
Beef Liver

Retinol, D3 ↓

Backfat, marbling ↑

Weak
4511
Beta-Sitosterol

Dermatitis unchanged

Itch/pain ↓11%

Weak
6711
Astragalus

Ulcers, +2.03%

Hand-foot syndrome, +26%

Weak
14917
Dandelion

Swelling ↓, +73% mouth opening

Pain unchanged

Weak
57
Skullcap

Cure↑ 94.74%

Relapse↓ 16.00%

Weak
2511
Krill Oil

Barrier, hydration, elasticity

TEWL -1.23; hydration +3.66

Weak
3815
Jiaogulan

Hair density +14/cm²

Hair elasticity/diameter +58 gf

Weak
88
Boswellia

Roughness/fine lines/elasticity

-

Erythema/steroid use

Weak
6014
Ginseng

Wrinkle reduction; collagen↑

Eye wrinkles, roughness↓

Weak
27118
Bilberry

Wrinkles −10.6%; smoother skin

Elasticity +12.4%; antioxidant +20.8%

Weak
278
Black Pepper

Repigmentation + significant

Burning, redness + piperine

Weak
3713
Saw Palmetto

Hair count +29

Shedding reduced

Weak
7810
Alpha-Linolenic Acid

Hydration ↑, TEWL ↓

Dryness/itch ↓, meds ↓

Weak
31119
Dodder Seed

Moisture, elasticity ↑

Itching ↓

Weak
32
Monolaurin

Less staph, lower severity

~95% fewer staph

Weak
56
Blueberry Extract

Aesthetic, elasticity, thickness

Elasticity +9.36%, thickness +8.42%

Weak
610
Cat's Claw

Stomatitis severity down; similar to miconazole

Candida counts down

Weak
44
Green Coffee Extract

Hydration, barrier, blood flow

+ hydration, - TEWL

Weak
148
MSM

Redness,papules,h hydration

Itching improved

Weak
4334
Kaempferol

Moisture/elasticity ↑

Itch ↓

Weak
1311
Noni

Leishmaniasis lesions: ~80% improved

Parasite activity: in vitro

Weak
76
Terminalia Arjuna

KOH negativity, itch

non-inferior vs terbinafine

Weak
3315
Colostrum

Skin/subcutaneous fat +5.5%

Limb size +2.3%

Weak
22217
Riboflavin

Acne improvement +2.6%

Less pain, fewer side effects

Weak
32415
Schisandra

Hydration ↑17.35, TEWL ↓4.41

Redness ↓54.61

Weak
1214