Alpha-Ketoglutarate

10 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Moderate

Protein anabolism +20%

Less catabolism; faster healing

Better strength/power

829 people

Exercise recovery

Moderate

Protein balance +20%

Wound healing -30d

228 people

Moderate

Fast graft closure +31d

Less protein breakdown

321 people

Stress resilience

Moderate

Nutrition↑, +127g

Wound healing↑, -16d

308 people

Weak

Healing faster: -30d

Less breakdown markers

Better nitrogen balance

101 people

Weak

GSH/vitamins +40%

Neopterin -30%

Acrylamide excretion ↑

95 people

Weak

Aerobic performance +VO2max

Power maintenance +7.3%

77 people

Weak

More appetite, weight, independence

QoL improved, lower costs

194 people

Weak

Bone resorption −37%

Bone thickness +21%

76 people

Energy & Fatigue

Weak

Lower injury, lactate

More α-KG, power

58 people

Main Effects

Protein anabolism +20%

Less catabolism; faster healing

Better strength/power

Moderate

829

Exercise recovery

Protein balance +20%

Wound healing -30d

Moderate

228

Fast graft closure +31d

Less protein breakdown

Moderate

321

Stress resilience

Nutrition↑, +127g

Wound healing↑, -16d

Moderate

308

Healing faster: -30d

Less breakdown markers

Better nitrogen balance

Weak

101

GSH/vitamins +40%

Neopterin -30%

Acrylamide excretion ↑

Weak

95

Aerobic performance +VO2max

Power maintenance +7.3%

Weak

77

More appetite, weight, independence

QoL improved, lower costs

Weak

194

Bone resorption −37%

Bone thickness +21%

Weak

76

Energy & Fatigue

Lower injury, lactate

More α-KG, power

Weak

58