Proof.Fit

Mental clarity

99 supplements analyzed and ranked by clinical evidence.

Supplements99

Supplement Evidence

Main Effects
Iron

Iron repletion: clarity +

Cognition link: Hb/ferritin

Strong
302216
Phenylethylamine

Attention/working memory +0.8

Executive function/remission +70%

Strong
357511
Caffeine

Reaction/memory +

Alertness/EEG +

Strong
73611
Ginkgo Biloba

Executive/processing +24s

Memory/attention +18%

Strong
22317
Aspartate

Ammonia↓, cognition↑

Memory/attention↑

Cognition↑, −1.75

Strong
201718
Vitamin B12

Memory+executive

B12↑,Hcy↓

Brain atrophy↓40%

Strong
95115
Choline

Memory + cognition

Attention + EEG

-3.2 ADAS-cog

Strong
76218
Folic Acid

Folate/B12 better clarity

Omega-3 boosts folate

Strong
274515
Iodine

Mental clarity +0.9

Thinking/motor +4 tests

Cognition +2.1 points

Strong
160217
Zinc

Better cognition +2

Mixed behavior/attention -37%

Improved neurodevelopment +14.8pp

Strong
180417
Galantamine

Cognition +3.6 pts

Function/global better

Attention/behavior improved

Strong
11010
Phenylalanine

Phe↓/LNAA↑, clarity↑

Phe↑, clarity↓

Strong
110316
Multivitamin

Memory +0.07 SD

Attention speed +8.5%

Anxiety/stress reduced

Strong
45018
Ginseng

Attention/memory +1.25d

Fatigue/stress ↓

Global cognition +2pt

Strong
27118
Vitamin B6

Memory/cognition +hcy

Brain atrophy −30%

Strong
54417
Vitamin B3

Cognitive recovery +14%

Stroke lesions -25%

Postop confusion -50%

Strong
55916
L-Tyrosine

Tyrosine boosts attention

and working memory

+38 ms reaction time

Strong
325211
L-Carnitine

Memory/attention +

Mental fatigue -

+29% cognition

Strong
46519
Panax Ginseng

Attention/working memory +

Fatigue/stress clarity +

Strong
21518
Anthocyanins

Memory↑, clarity↑

Attention↑, faster 3-5%

Inflammation↓, clarity↑

Strong
13119
Curcumin

Migraine fewer, clearer

Memory/attention + mood

Strong
36418
Ornithine

Ammonia↓, clarity↑

-15.4% recurrence

Strong
11514
Tryptophan

Memory worse

Attention/reaction better

-77% TRP

Strong
41313
Coenzyme Q10

Cognitive scores, slight gains

Oxidative stress, improves

Moderate
34817
Acetyl-L-Carnitine

Memory/attention +

Hepatic confusion/ammonia -

Stroke/function +

Moderate
9017
Lecithin

Memory/attention: +13%

AD decline: slower

Moderate
14213
L-Serine

Cognitive recovery +29%

Auditory plasticity/MMN +7-14%

Moderate
73717
Idebenone

Memory/attention/orientation +

ADAS cognition/global +

Moderate
2411
Piracetam

Better cognition +0.73 z

Perfusion/performance +7% to +85%

Moderate
15510
Glycine

Negative symptoms ↓ ~36%

Cognition/attention slightly improved

Moderate
91317
L-Dopa

Word learning + retention

WM/attention +3 mo

PD cognition peak-dose

Moderate
60613
Saffron

Cognition +0.8

Dementia severity

Stroke recovery

Moderate
10718
Oxiracetam

Global cognition +9

Attention/memory +

Reaction time +

Moderate
139
Pomegranate

Better cognition

Memory/clarity +3.2

Brain development

Moderate
10416
Theobromine

Cocoa: better alertness

Pentoxifylline: modest cognition

Moderate
29412
Lavender

Clarity/work memory +4.9

Calmer, less drowsy

Faster math/processing

Moderate
30311
Green Tea Extract

Attention/memory +5

EEG/fMRI activation

+10% NAA

Moderate
24417
Guarana

Attention +5-8%

Reaction time -17 ms

Mental fatigue reduced

Moderate
169
Sage

Memory/attention +sage

Fatigue/alertness +peppermint

Moderate
52116
Aniracetam

Cognitive tests +

Memory/MMSE 79%

Behavioral scores +

Moderate
76
Huperzine A

Cognition +11 points

Memory/behavior 58%

Cognition/ADL +4.6

Moderate
129
Thiamine

Memory + cognition

EEG + attention

Moderate
20515
Rhodiola Rosea

Attention/accuracy ↑

Fatigue/burnout ↓

Moderate
3715
Sulforaphane

Clearer processing (+p<0.05)

Behavior improved (−34%)

ADHD symptoms improved (d>1.0)

Moderate
4214
Rosemary

Alertness↑ anxiety↓

Memory↑ anxiety↓

Cognition↑ speed↑

Moderate
7715
Bacopa Monnieri

Memory/attention + stress

Stress/fatigue - p

Mood/memory +

Moderate
1311
Sarcosine

Sharper cognition/negative symptoms

~19-30% better

Global psychiatric gains

Moderate
3810
Theanine

faster, sharper attention

−30 to −150 ms

Moderate
3915
Vinpocetine

Cognition + function

Neurology recovery

Better blood flow

Moderate
188
Spirulina

Cognition +0.3 MMSE

Fatigue, learning

Development +0.7 motor

Moderate
5518
Lemon Balm

Memory + cognition

Anxiety/calmness + cortisol

+0.006 vs -0.085

Moderate
20011
Phosphatidylserine

Memory/cognition +0.7

Neurochemistry/metabolism +0.4

Moderate
5811
Peppermint Oil

Cognition/fatigue ↑

Anxiety/pain ↓

Delirium −11.2%

Moderate
4110
Citicoline

Memory +3.5; clarity

Attention/speed +, impulsivity -

Moderate
7614
Alpha-Lipoic Acid

Better cognition/mood

Less cognitive decline

Moderate
21217
Butyrate

Attention +42%

Mood/clarity, sleep, HE

Moderate
251515
Soy Isoflavones

Memory/fluency +8.5%

Planning/speed +7%

Moderate
35516
MCT Oil

Ketones↑, cognition↑

Inhibitory control↑, WM↑

Weak
5311
Barley Grass

Mood/depression -44%

Sleep/mood/focus improved

Weak
5915
PQQ

Memory/attention +

+14.4% BDNF

Prefrontal blood flow +

Weak
68
L-Theanine

Faster attention RTs

Better ERP attention

+38 ms

Weak
399
Mulberry

Cortisol ↓, attention/memory ↑

Working memory ↑, cortisol ↓

Weak
4912
S-Adenosyl Methionine

SAM ↑, cognition ↑

DAT/metabolites shift

Weak
8214
Turmeric

Less fatigue, better focus

Brain oxygenation, no clear clarity

Weak
19419
Ellagic Acid

Inflammation/BDNF:+21%

Cognition/attention:+

Weak
2515
Epigallocatechin Gallate

Attention/speed +

Memory/function +6.23

Emotion/sleep +

Weak
10919
Artemisinin

Clearance faster; cognition unchanged

Negatives improved; cognition unchanged

Weak
83912
Astaxanthin

Processing speed + cognition

Fatigue recovery - oxidative stress

Weak
5617
Colostrum

Cognition +8/15

Function +0.02

Stability 7/15

Weak
22217
Spermidine

Memory +0.17

Cognitive score +6.25

BDNF +12.1%

Weak
2611
Ubiquinol

Wearing-off: UPDRS -4.2

ADHD symptoms: ~34% vs 18%

Weak
3115
NADH

Better cognition, less sleepiness

ADAS-Cog ~29% better

MDRS + verbal fluency

Weak
15716
Black Walnut

Reasoning +11%

Cognition/sleep +8%

Reaction time faster

Weak
8515
Lion's Mane

Faster processing, +6.7%

Less stress, more recall

Faster reaction, happier

Weak
25
Eleuthero

Memory + anxiety: p<0.05

Attention/speed/accuracy: p<0.05

Weak
2011
Siberian Ginseng

Memory/language ↑

Attention/speed ↑

Weak
2111
Yohimbine

Alertness/attention ↑

Sedation/analgesia ↓ -60min

Weak
798
Fisetin

Better clarity; NIHSS improved

Inflammation lower; MMP-2/MMP-9, CRP

Weak
44
Pyritinol

Alertness/reaction: improved

Cognition/EEG: improved

Weak
77
Kudzu

Cognition + MMSE

Lipids unchanged

Weak
1911
Cod Liver Oil

IQ +4.1

DHA boost

Weak
3010
Quercetin

Faster reaction time

CBF trend, no change

Weak
14219
Desiccated Thyroid

T3↑ T4↓; clarity

Symptomatic subgroup +0.0008

Weak
97
Beta-Glucans

Fatigue ↓; clarity ↑

BAP ↑; RT variability ↓

Weak
16818
Gotu Kola

Clinical/EEG gains

Working memory + mood

Weak
3814
Astragalus

Fatigue ↓17.8; cognition ↑14.4

QOL ↑14.1; fatigue ↓16.5

Weak
14917
Kelp

Antioxidant boost, +BDNF/IGF-1

Memory gains, reduced oxidation

Weak
4812
Nicotinamide Riboside

Cognition +29%

Brain structure/metabolites

Weak
158
Garlic

BP −17/−12

Cerebral flow ↑

Weak
15317
Polygala Tenuifolia

Memory + recall

Working memory - errors

CERAD + visuospatial

Weak
38
Centrophenoxine

Cognition +2.5%

Cell hydration

Weak
45
Boron

EEG slowing, attention -

Memory, slower responses

Weak
1808
Fucoxanthin

Memory +8.9%

Attention; insulin ↓4.63

Weak
512
Schisandra

Attention/speed/accuracy +

Fewer errors trend

Weak
1214
Wormwood

Early attention ↑

Emotional salience ↓

Weak
479
D-Serine

Mood - anxiety ↓

Attention/memory +

Weak
2010
Goji Berry

Mental acuity improved

Fatigue/stress reduced

Weak
1917
Exogenous Ketones

Better mental clarity

Ketones +16% brain energy

Mild memory gains

Weak
175
Mucuna Pruriens

QoL, motor: similar

AEs +18.5%

Weak
19