L-Dopa

13 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Strong

ON/OFF time +1–2h

Motor score −2–6

45,974 people

Strong

ON/OFF +0.8h

Motor scores -2

QoL +

27,785 people

Strong

ON/off time +1–2h

Motor scores +2

23,729 people

Strong

ON↑ OFF↓

Motor better, no JC

22,993 people

Strong

ON/OFF time +1.4h

Motor scores -1.9

Tremor -70%

20,619 people

Strong

Motor benefit +60–70%

On-time/dose +1.7h

5,827 people

Energy & Fatigue

Strong

Energy+fatigue: ↑/↓

Fatigue: +/−

5,248 people

Strong

Mood ↑, anxiety ↓

Anhedonia ↓, confidence ↑

1,471 people

Moderate

RLS/PLM sleep +

sleep latency/quality +

1,719 people

Focus & concentration

Moderate

Focus+memory: better

Attention/executive: −

Learning/retention: better

556 people

Moderate

Motor symptoms +6.4

Cognition/speech fluctuates

ON/OFF −1.5h

1,225 people

Motivation & confidence

Moderate

Motivation/anhedonia +

Reward-learning/decision +

657 people

Moderate

Word learning + retention

WM/attention +3 mo

PD cognition peak-dose

445 people

Main Effects

ON/OFF time +1–2h

Motor score −2–6

Strong

45,974

ON/OFF +0.8h

Motor scores -2

QoL +

Strong

27,785

ON/off time +1–2h

Motor scores +2

Strong

23,729

ON↑ OFF↓

Motor better, no JC

Strong

22,993

ON/OFF time +1.4h

Motor scores -1.9

Tremor -70%

Strong

20,619

Motor benefit +60–70%

On-time/dose +1.7h

Strong

5,827

Energy & Fatigue

Energy+fatigue: ↑/↓

Fatigue: +/−

Strong

5,248

Mood ↑, anxiety ↓

Anhedonia ↓, confidence ↑

Strong

1,471

RLS/PLM sleep +

sleep latency/quality +

Moderate

1,719

Focus & concentration

Focus+memory: better

Attention/executive: −

Learning/retention: better

Moderate

556

Motor symptoms +6.4

Cognition/speech fluctuates

ON/OFF −1.5h

Moderate

1,225

Motivation & confidence

Motivation/anhedonia +

Reward-learning/decision +

Moderate

657

Word learning + retention

WM/attention +3 mo

PD cognition peak-dose

Moderate

445