Proof.Fit

L-Dopa

13 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Joint mobility

ON/OFF time +1–2h

Motor score −2–6

Strong
45,974
Daily comfort

ON/OFF +0.8h

Motor scores -2

QoL +

Strong
27,785
Wellbeing

ON/off time +1–2h

Motor scores +2

Strong
23,729
Joint comfort

ON↑ OFF↓

Motor better, no JC

Strong
22,993
Nerve health

ON/OFF time +1.4h

Motor scores -1.9

Tremor -70%

Strong
20,619
Productivity

Motor benefit +60–70%

On-time/dose +1.7h

Strong
5,827
Energy & Fatigue

Energy+fatigue: ↑/↓

Fatigue: +/−

Strong
5,248
Mood balance

Mood ↑, anxiety ↓

Anhedonia ↓, confidence ↑

Strong
1,471
Sleep quality

RLS/PLM sleep +

sleep latency/quality +

Moderate
1,719
Focus & concentration

Focus+memory: better

Attention/executive: −

Learning/retention: better

Moderate
556
Learning

Motor symptoms +6.4

Cognition/speech fluctuates

ON/OFF −1.5h

Moderate
1,225
Motivation & confidence

Motivation/anhedonia +

Reward-learning/decision +

Moderate
657
Mental clarity

Word learning + retention

WM/attention +3 mo

PD cognition peak-dose

Moderate
445