Proof.Fit

Endurance

79 supplements analyzed and ranked by clinical evidence.

Supplements79

Supplement Evidence

Main Effects
Iron

Iron stores +Hgb

Endurance +VO2

Strong
302216
Erythropoiesis-Stimulating Agents

Hb maintained

+1.3 g/dL

Transfusion reduced -83%

Strong
218511
Phenylethylamine

Cognition/alertness +

ADHD symptoms +

Mood/euphoria +

Strong
357511
Nitrate

↑ exercise tolerance

↓ angina/ischemia

Strong
98412
Creatine

Strength/power +10-30%

Less fatigue; water +1 kg

Strong
191214
Chondroitin

Pain/function ↓ ~75%

NSAID use ↓

Strong
2247
Electrolytes

Endurance +2.2 min

Buffering +6.4s/3.2s

Hydration +22 min

Strong
656714
Caffeine

Endurance +3-51%

Power/RPE: improved

Strong
73611
Vitamin B12

Endurance: +25.8% time

Endurance: +36% motor

Endurance: +1.97 ALSFRS-R

Strong
95115
L-Carnitine

Endurance time +45%

Walking distance +73%

Strong
46519
Ornithine

Ammonia↓, cognition↑

Recovery↑, stay↓

Strong
11514
Branched-Chain Amino Acids

BCAA/Leu: better endurance

Lower fatigue, +performance

Strong
142210
Carnitine

Endurance + walking

Fatigue + strength

Strong
47518
Glutathione

GSH↑, TTE↑ +8.4%

Oxidative stress↓, performance↑

Strong
124419
Alanine

Endurance +24% TTE

Strength/lean mass gains

Glycogen sparing −19

Moderate
302818
ATP

Glucose↑,fat↓

ATP recovery↑

Moderate
76111
Essential Amino Acids

Blood flow/endurance +14%

Fatigue/muscle loss -14%

Moderate
262919
Lutein

MPOD +10–35%

Contrast/vision faster, clearer

Moderate
2588
Theobromine

Walking +30-400%

LVEF +12%

Soreness/reaction improved

Moderate
29412
Ginseng

Endurance: ↑20%

Exercise tolerance: +30%

Moderate
27118
Ginkgo Biloba

Walking endurance ↑

Altitude tolerance ↑

VO2max +6%

Moderate
22317
L-Citrulline

VO2/performance +5%

Blood pressure -9 mmHg

Moderate
11711
Acetyl-L-Carnitine

Fatigue/function improved

Performance/endurance +11%

Moderate
9017
Coenzyme Q10

Aerobic capacity +13%

Walk/endurance +6MWD

Muscle/lung endurance

Moderate
34817
Glycine

Endurance: +22% work

Endurance: +16% work

Endurance: +1.4 g/dL Hb

Moderate
91317
NADH

Endurance +15%

Aerobic capacity +10.3%

Moderate
15716
Arginine

Endurance capacity +14%

Exercise economy/strain reduced

Walking distance +32 m

Moderate
125319
Hawthorn

Exercise capacity +10%

Symptoms/QoL improve

Cardiac workload lower

Moderate
16016
Beta-Alanine

TTE/thresholds +13%

Power/endurance reps +22%

Moderate
2546
Policosanol

Exercise + recovery

Walking +33–69%

Moderate
6512
DHEA

DHEA-S ↑, endurance +

Exercise + DHEA-S

+10% DHEA-S, endurance

Moderate
48716
Citrulline

Power/time fatigue +11%

+36% fatigue

Endurance/NO kinetics

Moderate
23013
Rhodiola Rosea

VO2max, endurance +3–4%

RPE, fatigue ↓

Jump/power +7–15%

Moderate
3715
Ashwagandha

Strength/size + recovery

Endurance: VO2max/time

Moderate
5018
Panax Ginseng

Endurance +20%

Oxygen use ↓

Recovery faster

Moderate
21518
Leucine

Endurance +18.1 m

Muscle preservation +1,019 g

Moderate
39217
HMB

Endurance: +VO2max

Threshold/delay: +9.1% OBLA

Recovery: 24h work capacity

Moderate
13213
Astaxanthin

Faster, +power

Better fat use

Moderate
5617
Oxiracetam

Cognition, reaction time

+8.97 LOTCA

Attention, cognition

Moderate
139
Multivitamin

Weight/fat ↓

Stamina/alertness ↑

Moderate
45018
Piracetam

Cognitive vigilance +7.1pp

Memory/perception

Moderate
15510
Bitter Orange

Aerobic/threshold +20%; lactate −27%

Power +3.2% / +38W

Moderate
25113
Astragalus

Endurance↑ 6MWD/finish

Endurance↑ recovery

Moderate
14917
Urolithin A

Endurance +muscle

VO2max +5-10%

Walk +33-61 m

Moderate
1517
Glutamine

Endurance: +21.6% VO2max

Endurance: +6MWD, stair-climb

Endurance: ammonia lower

Moderate
48516
Sodium Bicarbonate

Repeated sprint +4–21%

Short endurance +1–18%

Weak
55810
Huperzine A

Memory/cognition +58%

Daily function +4.6

Weak
129
D-Ribose

Exercise tolerance +53s

Heart function/QoL +25.8

Weak
2075
Bacopa Monnieri

Better memory/attention

Less stress/fatigue

Weak
1311
Reishi

Aerobic endurance, VO2max

Work capacity, well-being

Weak
1511
Ubiquinol

Recovery + blood counts

Arrhythmia markers -7.7 ms

Peak HR +11.9 bpm

Weak
3115
Idebenone

Respiratory decline ↓ +6.27%

Inspiratory reserve ↑ +5.78%

Weak
2411
Schisandra

Strength +7.7%

Lactate ↓

Knee strength +10.2Nm

Weak
1214
Alpha-Ketoglutarate

Aerobic performance +VO2max

Power maintenance +7.3%

Weak
6910
Beet Root

Lower O2 cost +25%

Longer time-to-exhaustion +22%

Weak
107
Bee Venom

Pain/function +1.1,+3.1

Better VAS/global ratings

Weak
2413
Thiamine

Endurance +11.6%

Lactate/HR improved

Weak
20515
Royal Jelly

Recovery +4.8%

Strength preserved +1kg

Weak
2712
Pine Bark Extract

Endurance +17%

NAD+ boost

Pain/walking improvement

Weak
5318
Pyritinol

Cognition, EEG improved

Weak
77
Aspartate

Sprint performance +23%

+65m VHIR

Recovery pH up

Weak
201718
Bee Pollen

Growth + FCR improved

WBC +8%

Weak
25
Jiaogulan

VO2max; RPE

20 km -4%

Weak
88
Nicotinamide Riboside

Walk +18 m, +22 m

Satellite cells +11

Weak
158
Ursolic Acid

Gait speed +0.4s

Mitochondrial genes up

Weak
56
Fucoxanthin

Aerobic capacity +2.8

Fat burning +12.1%

Bone density +0.020

Weak
512
Shilajit

Fatigue loss −7.1 pp

Collagen damage −38%

Weak
68
Polygala Tenuifolia

Memory + cognition

Recall/recognition gains

Weak
38
Spirulina

Antioxidant/anti-inflammatory recovery

Fatigue/endurance +8.9%

Weak
5518
Ribose

+28W, +1.8min endurance

Maintained sprint power

Weak
2067
Capsaicin

Endurance +1.4%

Perceived effort -0.8

VO2max +8%

Weak
24618
Citicoline

Fatigue/cognition improved

Emotional/autonomic improved

Weak
7614
GlyNAC

GSH restored, stress↓

Mito function↑

Weak
16
Matcha

Muscle gain, lower cortisol

Fatigue ↓ early training

Weak
1113
Red Yeast Rice

LDL, CRP, ET-1 −26–47%

Exercise tolerance improved

Weak
6814
Rauwolscine

Sprint power + work

Fatigue, lactate, noradrenaline

+1.34 kg loss

Weak
8310
Goji Berry

Energy/sleep up

GI regularity improved

Weak
1917
Mucuna Pruriens

Levodopa exposure/ON +110%

+21.9% ON time

Motor/QoL similar, AEs +18.5%

Weak
19
Terminalia Arjuna

Heart efficiency +LVEF

Lower fatigue

Weak
3315