Nitrate

BP↓ nitrite↑

Flow↑ pressure↓

Tolerance-related flow changes

↓BP +nitrite

↑Vasodilation +FMD

↑ exercise tolerance

↓ angina/ischemia

Exercise/time: +5-230%

Cardio-kidney protection: -21% CIN

Nitrate markers↓ BP -8/−4

Tolerance: BP↓ then wanes

Sildenafil amplifies nitrate hypotension

Nutrient uptake unchanged

Uptake ↑ flow

Uptake ↓ resistance

Exercise tolerance ↑

BP/O2 cost ↓

Oxidative cost ↓, endurance ↑

Fatigue ↓, cognition ↑

Angina/exercise tolerance ↑

Nitrite recovery +6.6 reps

Vasodilation recovery +31%

Soreness ↓, PPT +4%

Soreness ↓, performance preserved

DOMS ↓, VO2max +5.2

Improved Stroop +17%

Better reaction time -14ms

Strength/power +4-15%

VO2/BP/lactate shifts

Nitrate biomarkers ↑