Proof.Fit

Erythropoiesis-Stimulating Agents

11 benefits mapped to clinical evidence across supplements.

Benefit Evidence

Main Effects
Nutrition source

Hb↑/transfusions↓

Iron markers↑

Strong
185,236
Energy & Fatigue

Fatigue↓ Hb↑

Energy↑ Hb↑

Strong
93,136
Wellbeing

Hb↑, QoL↑

Transfusions↓, fatigue↓

Strong
68,699
Endurance

Hb maintained

+1.3 g/dL

Transfusion reduced -83%

Strong
66,557
Daily comfort

Hb stable/↑ ~1–2 g/dL

Less transfusion/ESA use

Strong
51,521
Respiratory comfort

Hb stable

+1.3 g/dL

Respiratory comfort unknown

Strong
23,294
Blood circulation

Hb↑, transfusions↓

+1.3 g/dL

Iron stores↑, Hb↑

Strong
25,574
Exercise recovery

Hb↑ + recovery

Iron stores↑ + faster

Strong
18,514
Mood balance

Hb↑ QoL↑

+1–3 g/dL

Transfusions↓ 20%

Strong
17,689
Focus & concentration

Hb/iron ↑, fatigue/QOL

Neuro/cognition +8-13 pts

Strong
8,900
Sleep quality

RLS symptoms −8 to −13

Sleep better, less meds

Moderate
1,078