73 supplements analyzed and ranked by clinical evidence.
Skin repair +11-fold
Acne/lesions ↓
Gut permeability ↓0.17→0.50
Antioxidants boost GSH
Oxidative damage -MDA
Detoxified cells +GPx
Oxidative stress↓, E+
Liver markers↓, histology↑
Muscle damage↓, CK−
Lower liver/blood toxicity
Higher folate biomarker levels
Better cancer control
Liver toxicity, discontinuation
DNA damage, apoptosis
Antioxidant defense ↑
Cell damage ↓
Mortality ↓ 89%→0%
AA↔EPA/DHA shift
Cell defense/function +20%
Oxidative stress ↓
Antioxidant stress ↓, cell health
Barrier function/oxidation ↑, cell health
Antioxidant defense +GSH
Liver/kidney protection -25%
A/V status + carotenoids
Cell damage ↓, repair ↑
Liver/oxidative protection
Cell damage −10%
Inflammation/antioxidants ↑
Choline depletion ↑ALT
Homocysteine ↓ with supplements
Myocardial protection +GIK
Potassium balance +BP
Cell pump/oxidative stress
Liver/DNA damage
Respiratory survival
Cell function ↑
DNA damage ↓
Liver safety stable
Cell counts recover
Anemia reduced
Oxidative/antioxidant + improved
Vision/cornea + better
Energy ↑, heart function
Sperm quality ↑, oxidative stress ↓
Blood markers, lesions heal
Cornea flattens ~−2 D
Choline deficiency: −30% PC
Liver fat improved +13.8
DHA/EPA enrichment: +4.7%
NAD+ boost; cell stress
Inflammation/oxidative stress reduced
Cancer/skin control improved
Antioxidant balance, injury markers
Immune/clinical recovery, less injury
ALA ↑; EPA ↑
Inflammation ↓; SBP ↓6.3
LDL ALA ↑89%
Antioxidant boost, GSH +40%
Inflammation/oxidative damage down
Cell function up
Inflammation ↓
Liver fat/enzymes −5%
Glucose/lipids −1%
Energy metabolism + cell protection
−55% glycogen use
Organ function, survival
Cell protection, -26% apoptosis
Tissue repair, +52% collagen
Renal protection, less injury
Anti-inflammatory, anti-apoptotic
Cell membrane barrier ↑
DNA/AGE damage ↓
Oxidative DNA damage ↓
Lipid oxidation/inflammation ↓
Lower LDL, oxidation
Reduced absorption, synthesis
Lower oxidative damage
Reduced cell growth
Enhanced detoxification
Cell growth ↓
Kidney protection
+BUN/Cr, −AKI
Reduced neuropathy symptoms
Metabolic-oxidative: MGO↓37%
Liver-glucose: enzymes/steatosis↓
Oral inflammation -10%
Diarrhea burden reduced
Reduced oxidative damage
+ALSFRS-R, +GCS
Anti-inflammatory + stem-cell
Lipid/BP improvement
Fibrosis/proteinuria reduction
Homocysteine ↓ 10–24%
Betaine/choline ↑, Hcy ↓
B12/IGF-1 ↑
Liver fibrosis/stiffness ↓
Oxidative/inflammatory markers ↓
Fatty acids up
Growth slight up
Oxidative stress ↓, TAC ↑
Anti-adhesion ↑, DNA damage ↓
vascular/cognitive +
antioxidant/autophagy +
Vascular/inflammation: −29%
Carotenoid/vitamin uptake: +15×
Oxidative/antioxidant shift
Reduced damage/inflammation
Slowed decline,+6.5mo
Protective estrogen shift
Endoxifen down
Liver/fat markers ↓
miRNAs ↓
Cholesterol/Ox-LDL -12%/-25%
Anti-inflammatory gene changes
AGEs -2.3 AU
Antioxidant boost; +11%
Inflammation ↓; HDL +11%
Growth + yield
MDA ↓
Mito marker ↑
Uridine/choline ↑; cell support
EEG network preserved +0.015
NAD+ ↑, cell health
Inflammation ↓, mitochondria unchanged
Dry mouth ↓
VVC symptoms ↓
Faster repair, less redness
Pain/reaction drop, healing up
Endurance +60.8m
Strength +12%
Neurology scores ↓3.0
Oxidative damage unchanged
Choline ↑; liver fat ↓
Choline ↑; cell support
Sperm binding ↑; +52%
DNA repair preserved
HDL +6.5 mg/dL
Copper uptake↓ 82%
Copper balance -6.54 μmol
Protein synthesis +46%
Methylation/homocysteine
Auditory/symptom improvement
Skin health: +moisture/-wrinkles
Cell stress: -37%/-42%
Vanadium↑; eGFR↓
Glucose↓, insulin genes↓
NAD+ up, no muscle gain
ALS function/strength up
AKI NAD+ up, safe
Energy ↑ ATP/NAD+
Cardiac function ↑ EF/BNP
Glucose ↓ 26 mg/dL
Mitochondria + gene expression
Gait speed -0.4s / -7.4s
Lean mass unchanged
↓ inflammation markers
↓ plaque thickness
Cognition/antioxidants ↑
ω-3/BDNF ↑
Less injury, +5% EF
More CoQ10, -6% oxidation
Antioxidant defense up
Oxidative damage, liver enzymes down
↓ Oxidative stress, -27%
↓ Lipids, -15%
Less diarrhea, less fluids
Fecal DM +5.0, diarrhea −29.6
Gene shifts; wound healing
Pantothenate -83%; pantetheine +1250%
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