Proof.Fit

Cell health

73 supplements analyzed and ranked by clinical evidence.

Supplements73

Supplement Evidence

Main Effects
Vitamin A

Skin repair +11-fold

Acne/lesions ↓

Gut permeability ↓0.17β†’0.50

Strong
130714
Glutathione

Antioxidants boost GSH

Oxidative damage -MDA

Detoxified cells +GPx

Strong
124419
Vitamin E

Oxidative stress↓, E+

Liver markers↓, histology↑

Muscle damage↓, CKβˆ’

Strong
181517
Vitamin B9

Lower liver/blood toxicity

Higher folate biomarker levels

Better cancer control

Strong
275814
Folic Acid

Liver toxicity, discontinuation

DNA damage, apoptosis

Strong
274515
Selenium

Antioxidant defense ↑

Cell damage ↓

Mortality ↓ 89%β†’0%

Strong
69617
Arachidonic Acid

AA↔EPA/DHA shift

Cell defense/function +20%

Oxidative stress ↓

Strong
59519
Vitamin C

Antioxidant stress ↓, cell health

Barrier function/oxidation ↑, cell health

Strong
151318
N-Acetyl Cysteine

Antioxidant defense +GSH

Liver/kidney protection -25%

Strong
62317
Beta-Carotene

A/V status + carotenoids

Cell damage ↓, repair ↑

Strong
80713
Zinc

Liver/oxidative protection

Cell damage βˆ’10%

Inflammation/antioxidants ↑

Strong
180417
L-Methionine

Choline depletion ↑ALT

Homocysteine ↓ with supplements

Strong
34317
Potassium

Myocardial protection +GIK

Potassium balance +BP

Cell pump/oxidative stress

Strong
319717
Choline

Liver/DNA damage

Respiratory survival

Strong
76218
Alpha-Lipoic Acid

Oxidative stress ↓

Cell function ↑

DNA damage ↓

Strong
21217
Artemisinin

Liver safety stable

Cell counts recover

Anemia reduced

Strong
83912
Riboflavin

Oxidative/antioxidant + improved

Vision/cornea + better

Strong
32415
Coenzyme Q10

Energy ↑, heart function

Sperm quality ↑, oxidative stress ↓

Strong
34817
Vitamin B2

Blood markers, lesions heal

Cornea flattens ~βˆ’2 D

Strong
40015
Phosphatidylcholine

Choline deficiency: βˆ’30% PC

Liver fat improved +13.8

DHA/EPA enrichment: +4.7%

Strong
29617
Vitamin B3

NAD+ boost; cell stress

Inflammation/oxidative stress reduced

Cancer/skin control improved

Strong
55916
Danshen

Antioxidant balance, injury markers

Immune/clinical recovery, less injury

Strong
12117
Alpha-Linolenic Acid

ALA ↑; EPA ↑

Inflammation ↓; SBP ↓6.3

LDL ALA ↑89%

Strong
31119
Resveratrol

Antioxidant boost, GSH +40%

Inflammation/oxidative damage down

Cell function up

Strong
17619
Anthocyanins

Oxidative stress ↓

Inflammation ↓

Strong
13119
Berberine

Liver fat/enzymes βˆ’5%

Glucose/lipids βˆ’1%

Strong
9916
L-Carnitine

Energy metabolism + cell protection

βˆ’55% glycogen use

Organ function, survival

Strong
46519
Aspartate

Cell protection, -26% apoptosis

Tissue repair, +52% collagen

Moderate
201718
Astragalus

Renal protection, less injury

Anti-inflammatory, anti-apoptotic

Moderate
14917
Carnosine

Oxidative stress ↓

Cell membrane barrier ↑

DNA/AGE damage ↓

Moderate
7717
Lycopene

Oxidative DNA damage ↓

Lipid oxidation/inflammation ↓

Moderate
19618
Phytosterols

Lower LDL, oxidation

Reduced absorption, synthesis

Moderate
30617
Sulforaphane

Lower oxidative damage

Reduced cell growth

Enhanced detoxification

Moderate
4214
Epigallocatechin Gallate

Oxidative stress ↓

Cell growth ↓

DNA damage ↓

Moderate
10919
Manganese

Kidney protection

+BUN/Cr, βˆ’AKI

Reduced neuropathy symptoms

Moderate
8714
Hesperidin

Metabolic-oxidative: MGO↓37%

Liver-glucose: enzymes/steatosis↓

Moderate
6416
L-Histidine

Oral inflammation -10%

Diarrhea burden reduced

Moderate
15916
Taurine

Reduced oxidative damage

+ALSFRS-R, +GCS

Moderate
24013
Sea Buckthorn

Anti-inflammatory + stem-cell

Lipid/BP improvement

Fibrosis/proteinuria reduction

Moderate
217
Betaine

Homocysteine ↓ 10–24%

Betaine/choline ↑, Hcy ↓

B12/IGF-1 ↑

Moderate
11816
Milk Thistle

Liver fibrosis/stiffness ↓

Oxidative/inflammatory markers ↓

Moderate
5114
Borage Oil

Fatty acids up

Growth slight up

Moderate
168
Cranberry

Oxidative stress ↓, TAC ↑

Anti-adhesion ↑, DNA damage ↓

Moderate
11014
Spermidine

vascular/cognitive +

antioxidant/autophagy +

Moderate
2611
Avocado

Vascular/inflammation: βˆ’29%

Carotenoid/vitamin uptake: +15Γ—

Oxidative/antioxidant shift

Moderate
4716
TUDCA

Reduced damage/inflammation

Slowed decline,+6.5mo

Moderate
129
Indole-3-Carbinol

Protective estrogen shift

Endoxifen down

Moderate
84
Chlorogenic Acid

Oxidative stress ↓

Liver/fat markers ↓

miRNAs ↓

Moderate
4616
Flaxseed Oil

Cholesterol/Ox-LDL -12%/-25%

Anti-inflammatory gene changes

AGEs -2.3 AU

Weak
11617
Acai Berry

Antioxidant boost; +11%

Inflammation ↓; HDL +11%

Weak
68
PQQ

Growth + yield

MDA ↓

Mito marker ↑

Weak
68
Uridine

Uridine/choline ↑; cell support

EEG network preserved +0.015

Weak
2206
Nicotinamide Riboside

NAD+ ↑, cell health

Inflammation ↓, mitochondria unchanged

Weak
158
Althaea Officinalis

Dry mouth ↓

VVC symptoms ↓

Weak
610
Vitamin B5

Faster repair, less redness

Pain/reaction drop, healing up

Weak
708
Urolithin A

Endurance +60.8m

Strength +12%

Weak
1517
Idebenone

Neurology scores ↓3.0

Oxidative damage unchanged

Weak
2411
Lecithin

Choline ↑; liver fat ↓

Choline ↑; cell support

Sperm binding ↑; +52%

Weak
14213
Ellagic Acid

DNA repair preserved

HDL +6.5 mg/dL

Weak
2515
Copper

Copper uptake↓ 82%

Copper balance -6.54 ΞΌmol

Weak
64718
L-Serine

Protein synthesis +46%

Methylation/homocysteine

Auditory/symptom improvement

Weak
73717
Rose Hip

Skin health: +moisture/-wrinkles

Cell stress: -37%/-42%

Weak
5210
Vanadium

Vanadium↑; eGFR↓

Glucose↓, insulin genes↓

Weak
116
Pterostilbene

NAD+ up, no muscle gain

ALS function/strength up

AKI NAD+ up, safe

Weak
55
Ribose

Energy ↑ ATP/NAD+

Cardiac function ↑ EF/BNP

Glucose ↓ 26 mg/dL

Weak
2067
Ursolic Acid

Mitochondria + gene expression

Gait speed -0.4s / -7.4s

Lean mass unchanged

Weak
56
Hawthorn

↓ inflammation markers

↓ plaque thickness

Weak
16016
Perilla Oil

Cognition/antioxidants ↑

Ο‰-3/BDNF ↑

Weak
77
Ubiquinol

Less injury, +5% EF

More CoQ10, -6% oxidation

Weak
3115
Chlorella

Antioxidant defense up

Oxidative damage, liver enzymes down

Weak
1812
Myricetin

↓ Oxidative stress, -27%

↓ Lipids, -15%

Weak
49
Dragon's Blood

Less diarrhea, less fluids

Fecal DM +5.0, diarrhea βˆ’29.6

Weak
55
Pantothenic Acid

Gene shifts; wound healing

Pantothenate -83%; pantetheine +1250%

Weak
585