Indole-3-Carbinol

Estrogen metabolism shift

+4.55 ratio

Tamoxifen metabolism changes

Estrogen ratio up, +4.55

Tamoxifen metabolites down, endoxifen

CIN regression, 50%

Protective estrogen shift

Endoxifen down

Estrogen metabolism +3.2

Tamoxifen metabolites ↓

CIN regression; 50%