Proof.Fit

Sleep quality

57 supplements analyzed and ranked by clinical evidence.

Supplements57

Supplement Evidence

Main Effects
GABA

Sleep improved; pain eased

Sleep worsened; sedation rose

Strong
15198
Melatonin

Sleep onset/quality

31%↓ delirium

Strong
6547
Lavender

Sleep quality +64%

PSQI -3.1

Deep sleep +2.5pp

Strong
30311
Probiotics

Vagal HRV + sleep

PSQI ↓ ~4

Stress hormones + sleep

Strong
294215
Valerian

Sleep quality + latency

Deep sleep + duration

Anxiety/stress eased

Strong
367
Tryptophan

TRP↓ melatonin↓

Sleep onset↓ duration↑

Sleep quality↑

Strong
41313
Cannabidiol

Pain/spasticity, sleep +

Sleep efficiency +6.85

Strong
2019
Omega-3 Fatty Acids

Sleep efficiency/time +58m

Fewer wakings/arousals

PSQI -1.7

Strong
288519
Marijuana

Sleep +0.2z

Sleep +64.6m

Sleep +5.1 ISI

Strong
117514
Fish Oil

Better sleep quality

+58 min sleep

Fewer sleep problems

Strong
290520
L-Dopa

RLS/PLM sleep +

sleep latency/quality +

Moderate
60613
Vitamin D

Sleep quality +1.7 PSQI

Sleep timing variability

Sleep duration +

Moderate
435919
Essential Amino Acids

Sleep quality ↑

+84 min sleep

+6.6% efficiency

Moderate
262919
Phenylalanine

PLM ↓, sleep ↑

Melatonin phase shift

Moderate
110316
Magnesium

Sleep quality ↑

Insomnia/cortisol ↓

SWS/EEG ↑

Moderate
183419
Prebiotics

Better sleep quality

Deeper sleep +N3

Faster night consolidation

Moderate
76915
Erythropoiesis-Stimulating Agents

RLS symptoms −8 to −13

Sleep better, less meds

Moderate
218511
Docosahexaenoic Acid

Duration↓wakings↑58min

Efficiency↑latency↓1.7pp

PSQI↑cortisol↓

Moderate
140520
Ashwagandha

Sleep quality, TST

Latency, efficiency

Moderate
5018
Saffron

Better sleep quality

+25 min TIB

Improved sleep efficiency

Moderate
10718
Calcium

Sleep continuity +TST

Sleep quality modestly

Sleep improved, -1.7

Moderate
877212
Theanine

Sleep onset −24 min

Sleep quality improved

Moderate
3915
Ephedrine

Less sleepiness

Sedation -7%

No MAP change

Moderate
56213
Chamomile

Sleep latency ↓16 min

Overall sleep quality improved

Insomnia severity, PSQI ↓

Moderate
7817
Hops

Sleep onset/quality +21.7 min

Deeper sleep, no next-day impairment

Morning slowing, then better sleep

Moderate
489
L-Theanine

Sleep quality + duration

Deep sleep +50%

Moderate
399
Casein

Sleep onset/quality: improved

Cortisol/stress: reduced

Sleep latency: -7.7 min

Moderate
35215
Lemon Balm

Sleep quality: +PSQI, −2.9 ISI

Deep sleep ↑, REM ↓

Moderate
20011
Glutathione

Melatonin/NAC: better sleep

Oxidative stress: +GSH, -MDA

Moderate
124419
NADH

Sleep quality, +PSQI

Sleep duration, improved

Sleepiness, reduced

Moderate
15716
Passion Flower

Subjective sleep quality +

Sleep duration/latency +23 min

Moderate
207
Vitamin B6

Less waking, better sleep

PSQI −44%, better sleep

Improved sleep with lithium

Moderate
54417
St. John's Wort

Sleep improved

Deep sleep +

Moderate
9711
Sage

Sleep maintenance, onset

Daytime sleepiness/functioning

Weak
52116
Bee Venom

Sleep quality: no data

Pain/swelling: worse sleep

Relapse -20%: better sleep

Weak
2413
Kava

Sleep quality: +

Sleep restoration: +

Weak
476
Palmitoylethanolamide

Pain ↓ sleep +

PSQI p<0.0001

Weak
4618
Aspartate

PSQI ↓, ALT/viremia ↓

PSQI ↑ slight

Weak
201718
Skullcap

Sleep quality ↑

TST +27 min

Weak
2511
Black Cohosh

Fewer night sweats

+73% hot flush drop

Better sleep efficiency

Weak
478
Ginseng

Improved sleep; +73% hot flushes

Sleep improved; MN 5.7→1.4

Weak
27118
Magnolia Bark

Insomnia improved more

Mood/anxiety better

Weak
67
Beta-Glucans

Better sleep +98 days

Less cold sleep issues

Weak
16818
Bacopa Monnieri

Sleep routine improved

No sleep change

Weak
1311
L-Serine

Faster sleep onset; +24 min

Longer, better sleep; +22 min

Weak
73717
Acetyl-L-Carnitine

Less fatigue, better sleep

MMSE +3.4

Weak
9017
Rhodiola Rosea

Better oxygenation, sleep stages

Less insomnia, +SaO2

Weak
3715
Black Walnut

Sleep quality + latency

Melatonin + sleep quality

Sleep quality, duration

Weak
8515
Phenibut

Anxiety/fatigue: sleep better

Sleep disorders down 79%

Weak
47
Fennel

Vasomotor symptoms −38%

Physical/social symptoms −24%

Weak
338
Inositol

Better sleep quality, -1.5

Longer sleep, better efficiency

Weak
27017
Soy Isoflavones

Sleep quality improved

NHP sleep p<0.001

Weak
35516
Ornithine

Sleep + mood; ratio↓

Sleep +15 min

Sleep modestly improved

Weak
11514
Panax Ginseng

Hot flushes/night sweats −73%

Sleep quality improved

Weak
21518
Wild Yam

Insomnia, total score↓

Anxiety↓, sleep better

Weak
1111
Hawthorn

Longer sleep +27 min

Lower anxiety −5%

Weak
16016
Goji Berry

Sleep improved

Less fatigue/stress

Weak
1917