St. John's Wort

Depression ↓, side effects ↓

+20% responders, fewer AEs

Depression relief ~50%

Fewer side effects

Hot flashes/QoL

Depression ↓, anxiety ↓

Anxiety/somatic ↓

Response +20%, HAMD −11

Depression scores −11 to −15

Side effects fewer than drugs

Relapse reduced; response +20%

Pain ↓ ~4

Depression ↓ ~11

Mood improvement +20%

Fewer side effects

Hot flashes, −50%

Mood/menopause, −42%

Sleep improved

Deep sleep +

EEG shifts; cognition +

Memory/mood +0.58d, attention mixed

Fatigue/sleep improved

70% symptom-free

PMS symptoms ↓

Depression/anxiety ↓

Physical/behavioral PMS ↓