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St. John's Wort

11 benefits mapped to clinical evidence across supplements.

Serves the goals:CognitionEnergyEssential HealthMen's HormonesOrgan Function

Benefit Evidence

Mood balance
Strong

Depression ↓, side effects ↓

+20% responders, fewer AEs

6,257 people
Wellbeing
Strong

Depression relief ~50%

Fewer side effects

Hot flashes/QoL

4,929 people
Stress & Anxiety
Strong

Depression ↓, anxiety ↓

Anxiety/somatic ↓

Response +20%, HAMD −11

3,774 people
Stress resilience
Strong

Depression scores −11 to −15

Side effects fewer than drugs

Relapse reduced; response +20%

3,356 people
Nerve health
Strong

Pain ↓ ~4

Depression ↓ ~11

2,412 people
Motivation & confidence
Moderate

Mood improvement +20%

Fewer side effects

1,050 people
Hormone balance
Moderate

Hot flashes, −50%

Mood/menopause, −42%

481 people
Sleep quality
Moderate

Sleep improved

Deep sleep +

166 people
Focus & concentration
Weak

EEG shifts; cognition +

Memory/mood +0.58d, attention mixed

82 people
Energy & Fatigue
Weak

Fatigue/sleep improved

70% symptom-free

39 people
Menstrual comfort
Weak

PMS symptoms ↓

Depression/anxiety ↓

Physical/behavioral PMS ↓

36 people

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Inositol

Shares 9 benefits: energy & fatigue, focus & concentration, hormone balance, menstrual comfort

Ashwagandha

Shares 7 benefits: energy & fatigue, focus & concentration, hormone balance, mood balance

Palmitoylethanolamide

Shares 7 benefits: energy & fatigue, focus & concentration, mood balance, nerve health

Acetyl-L-Carnitine

Shares 7 benefits: energy & fatigue, focus & concentration, mood balance, motivation & confidence

Phenylalanine

Shares 7 benefits: energy & fatigue, focus & concentration, mood balance, motivation & confidence

Tryptophan

Shares 7 benefits: energy & fatigue, focus & concentration, mood balance, sleep quality

Products with St. John's Wort

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128 products whose verified label declares St. John's Wort — not every bottle that mentions it in a title.

Nature's Way

Nature's Way St. John’s Wort Capsules, 700 mg per Serving, 180 ct

St. John's Wort 700 mg

$14.61St. John's Wort

Nutricost

Nutricost St John’s Wort Capsules (500mg) 120 Capsules, Gluten Free

St. John's Wort 1000 mg

$11.95St. John's Wort

Toniiq

Toniiq 1,000mg Ultra High Strength St. John's Wort Capsules (Non-GMO)

St. John's Wort · Hypericum perforatum (aerial parts) 4:1 extract · Std. to 0.3% Hypericin +1 more

$19.97St. John's Wort

agobi

agobi 9in1 Brain Support Supplement

Bacopa Monnieri 100 mg · Gotu Kola 100 mg · Ashwagandha 70 mg +6 more

$15.99Bacopa Monnieri

Bronson

Bronson St. John's Wort 700 mg Positive Mood Support, 90 Capsules

St. John's Wort, Powder 700 mg · St. John's Wort extract 100 mg

$9.99St. John's Wort

Carlyle

Carlyle St John's Wort Capsules

St. John's Wort 4800 mg · (Hypericum perforatum) (aerial) · (from 600 mg of 8:1 extract) +1 more

$17.29St. John's Wort