Proof.Fit

Stress resilience

59 supplements analyzed and ranked by clinical evidence.

Supplements59

Supplement Evidence

Main Effects
Nitrate

Exercise/time: +5-230%

Cardio-kidney protection: -21% CIN

Strong
98412
Lavender

Stress/anxiety ↓

Cortisol ↓

Sleep/function ↑

Strong
30311
Glutamine

Stress proteins/immune +HSP70

Injury/infection markers −~30%

Metabolic support, survival +26.7pp

Strong
48516
Tryptophan

Stress resilience: ↓ cortisol/anxiety

Stress resilience: ↑ mood/sleep

Strong
41313
Beta-Glucans

Stress: ↓cortisol, -1.8 cm waist

Stress: mood/energy ↑

Stress: inflammation ↓

Strong
16818
Alanylglutamine

Immune/infection ↓

Glucose/stress ↓

Strong
5412
St. John's Wort

Depression scores −11 to −15

Side effects fewer than drugs

Relapse reduced; response +20%

Strong
9711
Docosahexaenoic Acid

↓NE, stress

↓anxiety/cortisol

↑HRV, ↓MAP

Strong
140520
Multivitamin

Stress/anxiety ↓

QoL/alertness ↑

Strong
45018
L-Tyrosine

Catecholamine depletion: stress↓ resilience

Tyrosine/L-DOPA: stress↑ resilience

+16% vasoconstriction

Moderate
325211
Iron

Lower stress +25%

Better stress resilience

Moderate
302216
Cannabidiol

Anxiety/stress ↓

Craving/withdrawal ↓

Moderate
2019
Theanine

Lower anxiety/stress markers

Reduced stress response

Moderate
3915
Vitamin B6

Stress/anxiety ↓

-3 points

Moderate
54417
Aspartate

Pain/opioid -50–80%

Fear extinction improved

Moderate
201718
DHEA

DHEA↑, cortisol↓

-38% cortisol

Moderate
48716
Echinacea

Immune boost, stress protection

Less illness, shorter duration

Moderate
5413
Coenzyme Q10

Less stress, more energy

↓IL-6/MDA; ↓mortality

Moderate
34817
Rhodiola Rosea

Cardio stress -?

Stress/anxiety −3

Fatigue/attention +14.8%

Moderate
3715
L-Serine

Cortisol block: +4.9 ng/mL

DCS anxiolysis: 71% vs 25%

Moderate
73717
Ginkgo Biloba

BP/Cortisol stress

Anxiety/Mood stress

Moderate
22317
Ubiquinol

Heart function +7–8%

Stress/inflammation protection

Energy biomarkers −

Moderate
3115
Palmitoylethanolamide

Stress resilience +faster symptom relief

Stress resilience -inflammation -11.5

Moderate
4618
Phosphatidylserine

Lower cortisol/ACTH

Stress response ↓

Blunted cortisol +4.87

Moderate
5811
Phenylalanine

↓ recall, ↑ anxiety

↑ mood, ↓ anxiety

↑ stress hormones, flux

Moderate
110316
Bergamot

Stress/anxiety ↓

Cortisol ↓

Mood/sleep ↑

Moderate
3515
L-Theanine

↓ physiological stress

↓ anxiety/stress -17 to 22

↓ cortisol/HRV response

Moderate
399
Glycine

Oxidative stress, BP ↓

Immune recovery, TNF ↓

Moderate
91317
Valerian

Anxiety/stress ↓

Sleep/anxiety ↓

Moderate
367
Alpha-Ketoglutarate

Nutrition↑, +127g

Wound healing↑, -16d

Moderate
6910
Inositol

Reduced panic/depression

Stress scores improved

Moderate
27017
Choline

Stress resilience: HRV/BP +14%

Stress resilience: fetal cortisol -33%

Moderate
76218
Vitamin B2

Stress resilience +PSS -5.9

BP stress reactions improved

Weak
40015
Danshen

CD4/IFN-γ boost

+2.35 GAD-7

Weak
12117
Glycerol

Endurance +21–25%, HR↓

Fluid retention/plasma volume↑

Time-to-exhaustion, mass loss↓

Weak
3045
Eleuthero

Burnout, mood better

+ stress BP/HR response

Weak
2011
Carnosine

Stress resilience +10–24%

Mood/cognition benefit

Weak
7717
Vitamin B1

Stress↓ sleep↓

Dialysis↓ −18%

Weak
26717
Acetyl-L-Carnitine

Less withdrawal, pain

Mood/cognition boost

Weak
9017
Sarcosine

PANSS/SANS better

HAM-D/remission better

Weak
3810
L-Proline

Stress↓ collagen↑ 0.35

Metabolites shift; stress↓

Weak
96113
Silica

Gut inflammation ↓

Lead uptake ↓ 86-90%

Weak
79615
Siberian Ginseng

Anxiety -22%

Cardio stress response

Weak
2111
Vitamin B3

Stress system optimized

Stress resistance improved

Weak
55916
D-Ribose

KCCQ +26, EF +8%

BNP −72, ATP balance

Weak
2075
Maitake Mushroom

Fewer severe side effects

QOL recovery, +6 months

Weak
34
NADH

Stress resilience: cortisol -

Stress resilience: anxiety/HR -8.1

Stress resilience: glucose/redox +10%

Weak
15716
Milk Thistle

Hot flashes -69%

Menopausal symptoms down

Weak
5114
Sulforaphane

Depression symptoms -6%

Response rates +23%

Weak
4214
Cordyceps

Lower inflammation markers (-34%)

Reduced stress load (-20%)

Weak
216
Guarana

Decision speed +8.5%

HRV stability, delayed decrease

Weak
169
Urolithin A

Gut-metabolic boost; CRP↓

Immune youth shift; IL-2↓

Weak
1517
Thiamine

Stress -4.3

Sleepiness -1.2

Weak
20515
Gotu Kola

Startle reactivity ↓

30–60 min, no HR/BP

Weak
3814
Green Lipped Mussel

Activity/mobility +

Pain/recovery -

Weak
126
Schisandra

CV recovery, stress tolerance

+diastolic BP only

Weak
1214
Skullcap

Anxiety, mood, sleep

+27 min sleep

Weak
2511
Goji Berry

Stress↓ energy/sleep↑

GI regularity↑

Weak
1917
Ergothioneine

Mood maintained; fatigue ↓

Inflammation markers ↓; BDNF ↓

Weak
14