Proof.Fit

Liver support

56 supplements analyzed and ranked by clinical evidence.

Supplements56

Supplement Evidence

Main Effects
Alanine

ALT/liver tests↓

Liver histology/viral clearance↑

Strong
302818
Glutathione

Oxidative stress ↓, ALT ↓

GSH/GST ↑, injury ↓

Strong
124419
Omega-3 Fatty Acids

Liver enzymes/fat ↓

Cholestasis/bilirubin ↓

Strong
288519
Fish Oil

Liver enzymes ↓

Cholestasis/steatosis ↓

Strong
290520
N-Acetyl Cysteine

Survival/Liver function

+25pp

Biomarkers/Enzymes ↓

Strong
62317
Curcumin

ALT/AST ↓

Fat/stiffness ↓

Strong
36418
L-Methionine

ALT/cholestasis ↓

Fibrosis risk ↓

Liver prediction +0.06

Strong
34317
L-Carnitine

Ammonia/encephalopathy improved

ALT/liver function improved

Strong
46519
Carnitine

Ammonia/encephalopathy, +25%

Liver tests, survival

Strong
47518
Ornithine

Ammonia ↓, HE better

+25% recovery

+31.8% HE risk

Strong
11514
Docosahexaenoic Acid

Steatosis βˆ’53%, ALT

Triglycerides, insulin sensitivity

Liver enzymes ↓

Strong
140520
Phosphatidylcholine

Liver enzymes/steatosis ↓

Choline/PC status ↑

Strong
29617
Turmeric

Liver enzymes ↓

Liver severity ↓

Strong
19419
Berberine

Liver fat, ALT βˆ’5

Lipids/insulin, liver support

ALP/cholestasis, liver enzymes

Moderate
9916
Choline

Liver fat↓, ALT↓

Fibrosis↓, steatosis↓

Moderate
76218
S-Adenosyl Methionine

Cholestasis markers, itch

Liver protection, survival

Moderate
8214
Milk Thistle

ALT/AST ↓

Fibrosis/stiffness ↓

Moderate
5114
Danshen

Liver enzymes/fibrosis ↓

ALT 80%

Moderate
12117
Piperine

ALT/NAFLD ↓

Enzymes ↓ 35.8

ALP/NAFLD ↓

Moderate
5118
Taurine

Liver enzymes ↓

Portal pressure βˆ’12%

Moderate
24013
Chlorogenic Acid

AST/ALT βˆ’7

Fatty liver index

HGP ↓

Moderate
4616
Akkermansia muciniphila

AST -

Metabolites

Moderate
3614
Naringenin

Steatosis/fat βˆ’2.0%

Lipids/visceral fat

Moderate
166
Bergamot

Liver fat ↓11%

Steatosis grade better

Weight loss +4kg

Moderate
3515
Phytosterols

↓ phytosterols, GGT/ALT

↓ bile acids, pruritus

Moderate
30617
Alpha-Linolenic Acid

Liver fat ↓

Enzymes/inflammation mixed

CAP/TE ↓

Moderate
31119
Chlorella

ALT/AST/triglycerides -significant

Glucose/CRP/weight -significant

Moderate
1812
Anthocyanins

Liver enzymes down (-27.9)

Inflammation/apoptosis markers down

Weak
13119
Betaine

Fat loss, lower enzymes

CAP/TE ↓, BMI ↓

Weak
11816
Vitamin B3

ALT/GGT down, fat no change

Responders +6.1%; GGT/ALP down

Weak
55916
TUDCA

Liver enzymes down

ALP/symptoms improved

Albumin up

Weak
129
Artichoke Extract

Liver enzymes down

Fat/steatosis down -11.2%

Weak
2513
Fucoxanthin

ALT/CAP/HOMA-IR ↓

Liver fat ↓

Weak
512
Inositol

Steatosis/enzymes ↓

Oxidative stress ↓

Weak
27017
Black Seed Oil

Steatosis, ALT -32.6%

Liver tests improved

Weak
4915
Cornelian Cherry

Liver markers: CK-18 βˆ’18.4%

Fibrosis score: βˆ’0.2 points

Steatosis unchanged

Weak
57
Epigallocatechin Gallate

Liver fat βˆ’, CPT-1 +

AST/ALT normal, safe

Weak
10919
Ellagic Acid

Liver fat/stiffness, ALT (-27.9)

Enzymes/lipids, ALT (-10.3)

Weak
2515
Quercetin

ALT, liver fat -1.9%

Visceral fat, BMI

Weak
14219
Kudzu

hs-CRP -6.76%

ALDH +18.1%

Weak
1911
Pterostilbene

ALT/GGT ↓

Liver fat unchanged

Weak
55
Dihydromyricetin

Glucose/LDL/IR ↓

NAFLD support

Weak
25
Jiaogulan

AST,HOMA-IR down

BMI down

Weak
88
Conjugated Linoleic Acid

Lower liver fat

Fat loss, growth ↓

Weak
11014
Celery Seed

Liver labs improved

Sugar/lipids improved

Weak
86
Green Coffee Extract

Glucose/insulin -10/-4.4

Liver fat -30.4

Weak
148
Molybdenum

Liver tests improved

Copper absorption -82%

Weak
357
Baikal Skullcap

ALT↓, response↑

TCRVΞ²7↑

Weak
157
Myricetin

ALT, glucose -27%

Antioxidant stress -22%

Weak
49
Schisandra

ALT/AST ↓

Antioxidants ↑

Weak
1214
Sesamin

ALT/AST ↓

Oxidation lag time ↑

Weak
78
Reishi

Oxidative stress ↓27%

Liver enzyme ↓42%

Weak
1511
Hibiscus

↓ weight/fat, steatosis

↓ free fatty acids

Weak
3413
Dihydroberberine

Cholestasis markers down

Serotonin down

Weak
22
Riboflavin

Folate↑, tHcy↓

ALT -

Weak
32415
Noni

Acetaldehyde ↓

Hangover symptoms ↓

Weak
76