Proof.Fit

Brain health

58 supplements analyzed and ranked by clinical evidence.

Supplements58

Supplement Evidence

Main Effects
Vitamin B9

Cognition + homocysteine

~30% tHcy drop

Brain atrophy βˆ’40%

Strong
275814
Omega-3 Fatty Acids

Brain chemistry +memory

βˆ’15 pp vasospasm

Brain volumes +cognition

Strong
288519
Fish Oil

Brain inflammation/stress ↓

Cognition/behavior ↑

Strong
290520
Phenylalanine

Phe/DA brain effects

Phe lowering in PKU

Strong
110316
Docosahexaenoic Acid

Brain networks +0.015

+4 IQ / +7 MDI

Memory/attention + DHA

Strong
140520
Folic Acid

Memory/cognition +

Homocysteine ↓

Strong
274515
Vitamin D

Cognition + memory

+1.95 points

MS/PD lesion control

Strong
435919
Arachidonic Acid

AA/DHA boosts brain growth

+7 MDI; visual gains

AA/DHA balance matters

Strong
59519
Choline

Cognition +3.5%

Memory/behavior +25%

Strong
76218
Vitamin E

Brain oxidative/memory

Brain decline/lesions

Strong
181517
Phosphatidylcholine

Cognition +5–15%

Brain lipids/choline ↑

Attention/memory +

Strong
29617
Vitamin B3

Cognition/neurology improved

Ischemia reduced ~25%

NAD+ up, symptoms down

Strong
55916
N-Acetyl Cysteine

Cognition + memory

Addiction cravings βˆ’30%

Inflammation/brain markers

Strong
62317
Piracetam

Memory/cognition +0.7

Language/rehab gains

Seizures reduced 94%

Strong
15510
Alpha-Linolenic Acid

DHA/omega-3 status

Cognition/motor gains

Less migraine/MS risk

Strong
31119
Lecithin

Cognition +3.5%

Function/mood preserved

Dementia risk -18%

Strong
14213
Zeaxanthin

Brain signals + cognition

+5.4 memory, +0.89 FC

-1Ξ², +BDNF

Strong
1567
Vitamin B2

Migraine relief: βˆ’1.8 days

Stroke recovery: βˆ’25% lesion

Cognition/fatigue: improved scores

Strong
40015
Phosphatidylserine

Memory + cognition

EEG/glucose metabolism

Fatty acids/neurotransmitters

Strong
5811
L-Methionine

Memory/executive +0.84

+ methylation/choline

Depression response +18.5%

Moderate
34317
Resveratrol

Cognition/blood flow

Inflammation/neuronal protection

Moderate
17619
Citicoline

Brain metabolism +NAA/Cho

Gray matter + visual

Stroke/head injury outcomes

Moderate
7614
L-Serine

Brain function +29%

Neurotransmitters/EEG changes

Moderate
73717
Carnosine

Brain speed +17.7%

Memory preservation

Executive gains

Moderate
7717
Sulforaphane

Cognition + working memory

ASD/ADHD symptoms -34%

Schizophrenia negative symptoms dβ‰ˆ0.8

Moderate
4214
Vinpocetine

Cognition + stroke recovery

Blood flow + inflammation

Moderate
188
Sarcosine

Brain markers + symptoms

Depression benefit +19%

Schizophrenia symptoms βˆ’19%

Moderate
3810
Idebenone

Memory/attention up

ADAS cognition improved

Moderate
2411
Betaine

Methylation/cognition: βˆ’36% Hcy

Choline/betaine brain support

Moderate
11816
Danshen

Better brain recovery

Reduced injury markers

Moderate
12117
Vitamin K

Clotting ↑, hemorrhage ↓

PIVH -20.8%

Clotting ↑, hemorrhage ↓

Moderate
66214
Manganese

Neuropathy ↓; OR 0.62

Motor signs/tremor ↑

AIMS response +46.2%

Moderate
8714
D-Serine

Auditory plasticity/MMN ↑

Symptoms/cognition: +10%, βˆ’4%

Moderate
2010
Vitamin B1

Better memory, cognition

MoCA +3.7; mortality -24%

Moderate
26717
Chlorogenic Acid

Blood flow/oxygenation ↑

Attention/mood slightly better

Cognition/markers improved

Moderate
4616
Huperzine A

Cognition/ADL +4.6

Memory/behavior +58%

Moderate
129
TUDCA

Neuroprotection, less inflammation

ALS decline slowed +0.42/month

Survival +6.5 months

Moderate
129
Blueberry Extract

Memory +BP lower

Oxygenation + mood

Moderate
610
Copper

Amyloid/cognition +42

Neurological recovery faster

Cognition stabilized +2.1

Moderate
64718
Hesperidin

Cognition + attention

Fall risk -

MDA -14%

Weak
6416
Lycopene

Executive function +21 s

Oxidative stress βˆ’65 pg/mL

Weak
19618
Cod Liver Oil

IQ +4.1

DHA rises

Weak
3010
Ellagic Acid

↑BDNF, ↓cortisol, cognition

+21% BDNF; ↓depression

Weak
2515
Epigallocatechin Gallate

Attention/speed +

Memory/function +

Weak
10919
Alpha-GPC

Memory/behavior +3.7

Choline/memory +2.4

Weak
32
Benfotiamine

Psych symptoms ↓

Cognition decline ↓

Weak
209
Perilla Oil

Cognition + BDNF

Depression risk -9.6%

Weak
77
Avocado

Lutein +25%; cognition

Attention up; MPD up

Weak
4716
Flaxseed Oil

Executive +0.30

Motor -3.3

Omega-3 absorption 3x

Weak
11617
Polygala Tenuifolia

Memory + neurogenesis

-

Cognition + memory

Weak
38
Cinnamon

Migraine inflammation ↓

Mood, anxiety ↑

Weak
6114
Nicotinamide Riboside

Cognition +29%

Brain metabolism/NAD+

Hippocampal structure preserved

Weak
158
Bacopa Monnieri

Cognition +3.1

Inflammation/oxidative stress -

Weak
1311
Quercetin

Reaction time improved

CBF trend only

Weak
14219
Nicotine

Cognition/EEG: better memory, attention

Seizures: -1.64/day, near-zero

Weak
286215
Centrophenoxine

Cognitive performance improved

Intracellular water +2.2–2.5%

Weak
45
Pterostilbene

ALS function +

strength, lung function +

muscle/fat ratio +

Weak
55
Niacin

Improved dementia ratings

Boosted blood flow

Weak
30813