Proof.Fit

Hormone balance

50 supplements analyzed and ranked by clinical evidence.

Supplements50

Supplement Evidence

Main Effects
Iodine

TSH↑,Tg↓

Goiter↓,volume↓44%

Strong
160217
DHEA

DHEA↑ androgens/estrogens

HDL↓ cortisol↓

Strong
48716
Soy Isoflavones

Hot flashes/symptoms −40–61%

Estrogen metabolism +31% ratio

Androgens/FSH down

Strong
35516
Inositol

Insulin↓ testosterone↓ ovulation↑

Pregnancy/egg quality↑ hormones↓

Strong
27017
Selenium

Thyroid antibodies -36%

TSH/FT4 shifts

Strong
69617
Black Cohosh

Symptom relief; hormones unchanged

Hot flashes −85%

Endometrium: no estrogenic change

Strong
478
Magnesium

PTH/cortisol balance

Insulin/inflammation balance

Calcium absorption -12%

Strong
183419
Zinc

IGF-1/growth ↑

+48%, +20%

Testosterone/sex hormones ↑

Strong
180417
Aspartate

↑ LH/FSH, +5.4

↑ Testosterone/IGF-1, +0.8

Moderate
201718
Red Clover

Hot flushes, symptoms

+73.5% / -75.4%

Hormone balance, metabolism

Moderate
4010
L-Methionine

Immune ↓; TgAb −

Inflammation ↓; Steroidogenesis ↑

Moderate
34317
Ashwagandha

Thyroid + T3/T4

Stress/cortisol ↓

Sex hormones ↑ DHEA-S/testosterone

Moderate
5018
Kudzu

Menopause relief; FSH/LH stable

Vaginal estrogenic effects; VMI +172%

Moderate
1911
Berberine

Androgen↓, SHBG↑

Insulin resistance↓

Moderate
9916
Arachidonic Acid

AA/Oxylipins ↑; PTB risk

Hormones/stress: cortisol ↓

Moderate
59519
Flaxseed Oil

Phytoestrogens +160%

Androgen/insulin ↓

Moderate
11617
Fenugreek

Hormones ↑, symptoms↓

PCOS shift, cysts↓

Moderate
3213
Indole-3-Carbinol

Estrogen metabolism shift

+4.55 ratio

Tamoxifen metabolism changes

Moderate
84
Fennel

Bleeding +54 pp

Hormone symptoms improved

Endometrium +1.7 mm

Moderate
338
Hops

Hot flashes/symptoms −23.4

Hormone profiles no change

Moderate
489
Sage

Androgen down, ovulation up

Insulin resistance down

Moderate
52116
St. John's Wort

Hot flashes, −50%

Mood/menopause, −42%

Moderate
9711
Royal Jelly

Androgen ratios +0.05

PMS score -11.75

Menopause symptoms ↓

Moderate
2712
Black Walnut

Lipids + HbA1c LDL -6%, HbA1c -0.2%

Glucose/insulin control Insulin response +26%

Moderate
8515
Ellagic Acid

Cortisol↓, BDNH↑

AMH↓, LDL↓

Moderate
2515
Evening Primrose Oil

Hot flashes/sweating ↓

Irritability, CRP ↓

Hot flash severity -42%

Moderate
4810
Licorice

BP↑; renin/aldo↓

Insulin/PRL↓; cycles+

Vascular cortisol effects

Moderate
7815
Tribulus Terrestris

Testosterone/sexual function ↑

PSA ↑ 0.3

Moderate
239
Alpha-Linolenic Acid

Leptin -4.70 ng/mL

Insulin/testosterone down

Insulin resistance down

Moderate
31119
Pueraria Mirifica

MGCS ↓20-33

E2/FSH/LH slight↓

Symptoms ↓42-75%

Weak
85
Pea Protein

Insulin↑; glucagon↑

Glucose↓; insulin↑

NOx↑; BP↓

Weak
4514
Damiana

Menopause symptoms -

Embryo quality +22%

Weak
65
DIM

Estrogen shift +47%

Endoxifen ↓, SHBG ↑

Weak
2645
Shatavari

Hormones + symptoms

Breast/lactation support

Weak
25
Black Seed Oil

↓ leptin, IL-6

sperm quality improved

Weak
4915
Chrysin

Androgens/estrogen ↑

+342%

+103%

Weak
21
Dong Quai

Hot flushes, sleep 73%

Night sweats 69%

Weak
155
Kelp

TSH↑, T3↓

Iodine↑, TSH↑

Glucose control↓, inflammation↓

Weak
4812
Fucoxanthin

Hormone balance: insulin↓ HOMA-IR↓

Hormone balance: ALT↓ CAP↓

Weak
512
Saw Palmetto

Serum DHT unchanged; testosterone stable

Prostate DHT -32%

Weak
7810
Boron

Less cramps, duration

Lower pain severity

Weak
1808
Maitake Mushroom

Ovulation ↑ 77%

Cycle ovulation ↓ 42%

Combo rescue 7/7

Weak
34
Phytosterols

Symptom score −13.7

Vasomotor worse, LDL

Weak
30617
Alanine

Hormone balance +alanine

Glucose/IGF-I shifts

Weak
302818
Wild Yam

Greene score -12mo

Hormone profile improved

Weak
1111
D-Aspartic Acid

Testosterone +16%

Sperm motility +43%

Weak
162
Chlorophyll

GLP-1 up, −5kg

LDL/total cholesterol down

Weak
1310
Schisandra

Menopause symptoms ↓

Hot flushes/palpitations ↓

Weak
1214
Pumpkin Seed Oil

Hormone symptoms ↓4.9

BP/HDL shift

Weak
58
Forskolin

Fat loss, free T +17%

Higher free testosterone

Weak
137