43 supplements analyzed and ranked by clinical evidence.
↓ anxious stress; +10–29%
↓ withdrawal/craving; fewer anxious days
Anxiety↓ stress†
Sleep/attention↓ anxiety
Cortisol/HR↓ stress
Craving↓; anxiety↓
Stress/anxiety↑; craving↑
Anxiety↓ cortisol↓
Sleep/stress↓ 5-10
Mood/agitation↓
Anxiety, cortisol ↓
Sleep, stress ↓
Anxiety ↓, stress ↓
Cue-craving ↓, anxiety ↓
Anxiety ↑; Trp ↓
Stress hormones ↑; mood ↓
Panic/anxiety ↑; Trp ↓
Lower anxiety/stress
Reduced withdrawal anxiety
THC anxiogenic; CBD anxiolytic
Depression ↓, anxiety ↓
Anxiety/somatic ↓
Response +20%, HAMD −11
Anxiety ↓ 5.2
Depression/stress ↓
Wellbeing/sleep ↑
↓ Anxiety/Stress
↓4‑herb, −1.19 d
↓ Depression/Anxiety
Stress/anxiety ↓
Sleep ↑, anxiety ↓
Stress/anxiety ↓ p<0.04
Depression/anxiety ↓ p<0.001
Stress/anxiety ↓ PSS
Anxiety ↓ HAM-A −41%
Anxiety ↓; cortisol ns
Sleep time +23 min
Anxiety, sAA ↓
BP stress response ↓
Cortisol, anxiety ↓
Anxiety↓; sAA↓
Stress markers↓; BP↓
Anxiety↓; HR↓
Anxiety ↓, remission +20%
Sleep/well-being improved
Mood/anxiety ↓ (d=2.24)
Anxiety/stress −2.4
Depression/suicide
Anxiety/stress ↓
Stress markers ↓
Sleep/time ↑
Stress/anxiety ↓, HR ↓
Cortisol ↓, mood ↑
Stress/anxiety ↓ PSS, VAS-A
Cortisol↓ HRV↑, anxiety↓
Cortisol/stress ↓
Mood/fatigue ↓
HOMA‑IR −1.1
Pain relief −2.5
Lower BP, breathing
Anxiety relief 79%
Fatigue/sleep improvement
Burnout/anxiety ↓
Stress response ↓
Mood & burnout
Anxiety ↓; mood/sleep ↑
Anxiety ↓; sleep ↑
Anxiety↓ −5%
Stress markers↓
Sleep +27 min
Anxiety −2.07; sleep +27m
Depression/anxiety improved modestly
Migraine symptoms down
Menopausal psychological -3.74
Panic/OCD symptoms reduced
Mood/anxiety improved
Sleep/mood ↓ stress
Stress score -5.8
Insomnia, anxiety, mood improved
No % reported
Mood/anxiety −51%
Blues −16.4%
Anxiety down significantly
Pre-op anxiety -P=0.001
Stress hormones ↓
HRV/feelings improved
Pain ↓ 2.9–4.9
No inflammation change
Less stress, lower anxiety
Improved symptoms, less bleeding
Trait anxiety ↓16.8%
Total anxiety ↓17.8%
Lower pain, stiffness
Higher pain threshold
↓ cortisol/DHEA-S, better sleep
↓ anger-hostility
Anxiety/depression ↓ -6.78/-3.63
Blood pressure ↓
Stress ↓ −9.5
Speed ↑ 6.7%
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