Proof.Fit

Gut health

46 supplements analyzed and ranked by clinical evidence.

Supplements46

Supplement Evidence

Probiotics
Strong

Microbes↑, diarrhea↓

Gut bacteria, inflammation↓

Barrier leak↓, SCFAs↑

2942 studies·15 benefits
Fiber
Strong

Microbiome+SCFA

Gut barrier+LPS

3645 studies·13 benefits
Prebiotics
Strong

Bifido↑,SCFA↑

Inflammation↓,permeability↓

769 studies·15 benefits
Butyrate
Strong

SCFA↓ butyrate↓

SCFA↑ pH↓

2515 studies·15 benefits
Vitamin A
Strong

Gut barrier ↓ leakiness

Gut inflammation ↓ infection

1307 studies·14 benefits
Glutamine
Strong

Barrier↓, permeability↓

Inflammation↓, mucositis↓

Absorption↑, diarrhea↓

485 studies·16 benefits
Inulin
Strong

Bifido↑ SCFA↑

Barrier↓ LPS↓

Steatosis↓ inflammation↓

291 studies·12 benefits
Colostrum
Strong

Gut barrier↓

Diarrhea↓

Infection↓

222 studies·17 benefits
Lactoferrin
Strong

Microbiota shift + pH↓

H. pylori eradication +13%

188 studies·15 benefits
Cranberry
Strong

SCFA/bile acids shifts

UTI anti-adhesion -51%

S. mutans ↓

110 studies·14 benefits
Akkermansia muciniphila
Strong

Gut barrier/metabolic ↑

Microbes/pH/SCFAs changes

36 studies·14 benefits
Berberine
Strong

H. pylori: +50%

Diarrhea: -30%

99 studies·16 benefits
Alanylglutamine
Moderate

Barrier/leakiness ↓

Immune/absorption ↑

54 studies·12 benefits
Propolis
Moderate

Plaque/gingiva ↓

Pathogens ↓ (e.g., S. mutans 4.35→0.89)

95 studies·16 benefits
Beta-Glucans
Moderate

Gut bacteria shift: Enterobacter↓

SCFA rise, inflammation↓

LDL/cholesterol↓, glucose↓

168 studies·18 benefits
Turmeric
Moderate

Gut symptoms↓, ~40%

Bile acids/metabolites↓

UC relapse↓, ~16pp

194 studies·19 benefits
Neem
Moderate

Plaque/gum inflammation

S. mutans reduction

Endotoxin/pain lower

19 studies·13 benefits
Cinchona
Moderate

Parasite clearance; QTc +3

Absorption/bioavailability; cure 100%

9 studies·5 benefits
Spermidine
Moderate

Polyamines up in gut

Transit/function changes

Colorectal risk biomarker shift

26 studies·11 benefits
Anthocyanins
Moderate

Gut microbes/metabolites

Barrier/inflammation markers

131 studies·19 benefits
Psyllium
Moderate

SCFAs↑; butyrate↑

Constipation relief; BMs↑

97 studies·12 benefits
L-Proline
Moderate

Mucositis/reflux ↓

Constipation: stool ↑

961 studies·13 benefits
Black Walnut
Moderate

Butyrate bacteria ↑

Bile acids ↓

85 studies·15 benefits
Chicory Root
Moderate

Butyrate/SCFAs +17%

Bifidobacteria, softer stools

+33% stools/week

8 studies·9 benefits
Oregano Oil
Moderate

Methanogens ↓

Protease/ammonia ↑

9 studies·4 benefits
Monolaurin
Moderate

Lacto ↑, pathogens ↓

H. pylori cure +21%

5 studies·6 benefits
Artichoke Extract
Moderate

Bifido/Lacto ↑; Bacteroides ↓

Diversity ↑; Bifido ↑

FFMI +0.2

25 studies·13 benefits
Arabinogalactan
Moderate

Better microbiota, lower ammonia

Faster diarrhoea recovery +27%

12 studies·6 benefits
Hesperidin
Weak

Gut absorption ↓29.7→9.3 μmol

Stool phytochemicals ↑37-fold

64 studies·16 benefits
Fumaric Acid
Weak

Gut bacteria+constipation

Diarrhoea↓, growth↑

SCFA↓, harmful E. coli↓

36 studies·7 benefits
Black Pepper
Weak

Diarrhea cure ↑

Bloating symptoms ↓

37 studies·13 benefits
Caprylic Acid
Weak

MCFA ↑ caprylic, SCFA

Caprylic acid ↓ pathogens

34 studies·6 benefits
Althaea Officinalis
Weak

Oral comfort, QoL

VVC symptoms better

6 studies·10 benefits
Urolithin A
Weak

Urolithins +100% producers

Butyrate +66%

15 studies·17 benefits
Sulforaphane
Weak

↓ H. pylori, inflammation

↓ MDA; detox genes ↑

42 studies·14 benefits
Guava Leaf
Weak

Diarrhea quicker −35%

Pain shorter

4 studies·5 benefits
Dragon's Blood
Weak

Firmer stools, +5% DM

Less diarrhea, -30% incidence

5 studies·5 benefits
Chitosan
Weak

Gut microbes -↓/↑

Gut barrier/morphology +

Infection burden -58%

116 studies·18 benefits
Kaempferol
Weak

IL-6 -18% lower

Adenoma recurrence -83%

13 studies·11 benefits
Irish Moss
Weak

Gut microbes +4–14×

SCFAs, villi ↑

3 studies·1 benefit
Coptis
Weak

Pain/diarrhea relief

Fatigue/anorexia improved

9 studies·13 benefits
White Kidney Bean
Weak

Glucose/insulin −23%

Microbiota, HbA1c ↓

5 studies·10 benefits
Garlic
Weak

Symptom, mucosa +29%

H. pylori, metaplasia

153 studies·17 benefits
Glucomannan
Weak

Bowel function +27%

Gut microbes/SCFAs increased

HbA1c −0.38%

32 studies·12 benefits
Yacon
Weak

Transit −21.3h

Antioxidants +79.2

Postmeal insulin↓

4 studies·4 benefits
Dihydroberberine
Weak

Liver markers↓, 5-HT↓

Gut serotonin↓

2 studies·2 benefits