Proof.Fit

Gut health

46 supplements analyzed and ranked by clinical evidence.

Supplements46

Supplement Evidence

Main Effects
Probiotics

Microbes↑, diarrhea↓

Gut bacteria, inflammation↓

Barrier leak↓, SCFAs↑

Strong
294215
Fiber

Microbiome+SCFA

Gut barrier+LPS

Strong
364513
Prebiotics

Bifido↑,SCFA↑

Inflammation↓,permeability↓

Strong
76915
Butyrate

SCFA↓ butyrate↓

SCFA↑ pH↓

Strong
251515
Vitamin A

Gut barrier ↓ leakiness

Gut inflammation ↓ infection

Strong
130714
Glutamine

Barrier↓, permeability↓

Inflammation↓, mucositis↓

Absorption↑, diarrhea↓

Strong
48516
Inulin

Bifido↑ SCFA↑

Barrier↓ LPS↓

Steatosis↓ inflammation↓

Strong
29112
Colostrum

Gut barrier↓

Diarrhea↓

Infection↓

Strong
22217
Lactoferrin

Microbiota shift + pH↓

H. pylori eradication +13%

Strong
18815
Cranberry

SCFA/bile acids shifts

UTI anti-adhesion -51%

S. mutans ↓

Strong
11014
Akkermansia muciniphila

Gut barrier/metabolic ↑

Microbes/pH/SCFAs changes

Strong
3614
Berberine

H. pylori: +50%

Diarrhea: -30%

Strong
9916
Alanylglutamine

Barrier/leakiness ↓

Immune/absorption ↑

Moderate
5412
Propolis

Plaque/gingiva ↓

Pathogens ↓ (e.g., S. mutans 4.35→0.89)

Moderate
9516
Beta-Glucans

Gut bacteria shift: Enterobacter↓

SCFA rise, inflammation↓

LDL/cholesterol↓, glucose↓

Moderate
16818
Turmeric

Gut symptoms↓, ~40%

Bile acids/metabolites↓

UC relapse↓, ~16pp

Moderate
19419
Neem

Plaque/gum inflammation

S. mutans reduction

Endotoxin/pain lower

Moderate
1913
Cinchona

Parasite clearance; QTc +3

Absorption/bioavailability; cure 100%

Moderate
95
Spermidine

Polyamines up in gut

Transit/function changes

Colorectal risk biomarker shift

Moderate
2611
Anthocyanins

Gut microbes/metabolites

Barrier/inflammation markers

Moderate
13119
Psyllium

SCFAs↑; butyrate↑

Constipation relief; BMs↑

Moderate
9712
L-Proline

Mucositis/reflux ↓

Constipation: stool ↑

Moderate
96113
Black Walnut

Butyrate bacteria ↑

Bile acids ↓

Moderate
8515
Chicory Root

Butyrate/SCFAs +17%

Bifidobacteria, softer stools

+33% stools/week

Moderate
89
Oregano Oil

Methanogens ↓

Protease/ammonia ↑

Moderate
94
Monolaurin

Lacto ↑, pathogens ↓

H. pylori cure +21%

Moderate
56
Artichoke Extract

Bifido/Lacto ↑; Bacteroides ↓

Diversity ↑; Bifido ↑

FFMI +0.2

Moderate
2513
Arabinogalactan

Better microbiota, lower ammonia

Faster diarrhoea recovery +27%

Moderate
126
Hesperidin

Gut absorption ↓29.7→9.3 μmol

Stool phytochemicals ↑37-fold

Weak
6416
Fumaric Acid

Gut bacteria+constipation

Diarrhoea↓, growth↑

SCFA↓, harmful E. coli↓

Weak
367
Black Pepper

Diarrhea cure ↑

Bloating symptoms ↓

Weak
3713
Caprylic Acid

MCFA ↑ caprylic, SCFA

Caprylic acid ↓ pathogens

Weak
346
Althaea Officinalis

Oral comfort, QoL

VVC symptoms better

Weak
610
Urolithin A

Urolithins +100% producers

Butyrate +66%

Weak
1517
Sulforaphane

↓ H. pylori, inflammation

↓ MDA; detox genes ↑

Weak
4214
Guava Leaf

Diarrhea quicker −35%

Pain shorter

Weak
45
Dragon's Blood

Firmer stools, +5% DM

Less diarrhea, -30% incidence

Weak
55
Chitosan

Gut microbes -↓/↑

Gut barrier/morphology +

Infection burden -58%

Weak
11618
Kaempferol

IL-6 -18% lower

Adenoma recurrence -83%

Weak
1311
Irish Moss

Gut microbes +4–14×

SCFAs, villi ↑

Weak
31
Coptis

Pain/diarrhea relief

Fatigue/anorexia improved

Weak
913
White Kidney Bean

Glucose/insulin −23%

Microbiota, HbA1c ↓

Weak
510
Garlic

Symptom, mucosa +29%

H. pylori, metaplasia

Weak
15317
Glucomannan

Bowel function +27%

Gut microbes/SCFAs increased

HbA1c −0.38%

Weak
3212
Yacon

Transit −21.3h

Antioxidants +79.2

Postmeal insulin↓

Weak
44
Dihydroberberine

Liver markers↓, 5-HT↓

Gut serotonin↓

Weak
22