Proof.Fit

Pain relief

36 supplements analyzed and ranked by clinical evidence.

Supplements36

Supplement Evidence

Main Effects
Capsaicin

Pain relief, desensitization +30%

Rapid relief, fewer AEs

Strong
24618
Caffeine

Pain relief +26 pp

Faster onset, longer relief

Strong
73611
Electrolytes

Rehydration reduces thirst

Prevents hyponatremia

Strong
656714
Marijuana

THC-rich analgesia

Men/cannabis only

+30% responders

Strong
117514
Aloe Vera

Pain relief: strong

Pain relief: +76%

Strong
11312
DMSO

Pain-free +40pp

Pain VAS -1.8

Pain relief > BTH

Strong
8712
Bromelain

Pain ↓, function

Pain ↓, swelling ↓

Strong
4510
Palmitoylethanolamide

Pain scores down

Pain/function improved

Strong
4618
Comfrey

Pain ↓, 10%>1%

Pain ↓, placebo>diclofenac

Pain ↓, 27-50%

Moderate
115
Nicotine

Acute pain ↓; opioids ↓

Withdrawal pain ↑; hyperalgesia ↑

Central pain unchanged

Moderate
286215
Chamomile

Pain cut ~50%

Pain relief + symptoms

Analgesic use down

Moderate
7817
S-Adenosyl Methionine

Itching, liver tests

Pain relief, similar by 8w

Moderate
8214
Propolis

Pain relief -4.0

Healing faster 80%

Moderate
9516
Bee Venom

Pain ↓, function↑

VAS −4

Pain relief +

Moderate
2413
Boswellia

Threshold/tolerance ↑

+PPR/MPR faster

Pain scores ↓

Moderate
6014
Corydalis

Pain↓ 3.8

Pain/function↑

Adverse↓ 24%

Moderate
116
Clove

Oral heat pain +desensitization

Needle pain -1.7 VAS

Anal fissure healing +48%

Moderate
338
Papain

Less pain, +32%

Longer time, less pain

Moderate
283
Butterbur

Fewer attacks (-60%)

Higher responders (68%)

Moderate
116
Peppermint Oil

Headache relief, -54.2%

Knee pain, improved

Pressure pain, reduced

Moderate
4110
Myrrh

Pain -76.7%

Pain ↓ dose-dependent

Moderate
279
Elderberry

Pain relief: faster/less

~2 days shorter

Pain relief: reduced severity

Moderate
209
Arnica

Pain↓, soreness↓

Bruise/ecchymosis↓

Moderate
228
Willow Bark

Pain-free +33pp

Less tramadol

Pain ~20-35% better

Weak
84
Dragon's Blood

Pain: +2.1%

Pain: +11.7%

Weak
55
Serrapeptase

Pain↓ 63%

Pain+swelling↓

Pain↓ vs placebo

Weak
67
Feverfew

Migraine attacks −0.6

2h pain relief +24%

Weak
51
Neem

Neem-coconut: pain -3.0

Neem dressing: pain -4.9

Weak
1913
Devil's Claw

Pain ↓, threshold ↑

WOMAC pain -19.6

Weak
29
Piperine

PGE2↓; pain relief

Inflammation↓, unclear pain

Weak
5118
Horse Chestnut

Edema relief: -44 mL

Stocking-like effect

Weak
88
Yarrow

Episiotomy pain ↓

Dysmenorrhea pain ↓

Weak
287
Agmatine

Pain ↓26.7%

Function / QOL ↑70.8%

Weak
53
Cramp Bark

Pain relief: -27.9%

Faster expulsion: -4.7d

Weak
12
Lavender

Role QOL +10

No disability change

Weak
30311
Witch Hazel

Mild redness reduction, ~20–27%

Stronger anti-inflammation, no pain data

Weak
63