Proof.Fit

Daily comfort

24 supplements analyzed and ranked by clinical evidence.

Supplements24

Supplement Evidence

Main Effects
Erythropoiesis-Stimulating Agents

Hb stable/↑ ~1–2 g/dL

Less transfusion/ESA use

Strong
218511
L-Dopa

ON/OFF +0.8h

Motor scores -2

QoL +

Strong
60613
Chondroitin

Pain/function ↓

NSAID need ↓

Strong
2247
Marijuana

Less substance use: −59%

Better mood/family/function

Strong
117514
Cannabidiol

Pain/sleep: better, +11%

Spasticity: better, +45%

Sedation/AE: worse, 31%

Strong
2019
Glucosamine

Pain/function ↓ ~25-50%

Less NSAID use

Joint space preserved +0.3mm

Strong
2348
Turmeric

Pain ↓; comfort ↑

Function ↑; daily ease ↑

Strong
19419
Galantamine

Daily tasks +32 min

Function preserved 3.3 pts

Caregiver burden −67%

Strong
11010
Type-II Collagen

Pain/function improvement

Biomarker shifts -31%

Strong
2819
HMB

Strength/mobility +17%

Mass/weight gains

Hospital stay -4.3d

Strong
13213
DMSO

pain relief / fewer days

better comfort, faster recovery

less procedure pain

Strong
8712
Palmitoylethanolamide

Pain/comfort up

+10% pain relief

Symptoms/function improved

Moderate
4618
NADH

Fatigue/recovery +31%

Physical function +15%

Cognition/sleep improved

Moderate
15716
Bee Venom

Pain relief + function

Less discomfort/anxiety

Moderate
2413
Sarcosine

Psychosis relief +19%

Mood/cognition gains -4.6

Moderate
3810
D-Mannose

UTI relief, fewer recurrences

+88.6% cure; -60.8% recurrences

Moderate
774
Corydalis

Pain relief & function

Respiratory/allergy relief

Moderate
116
Mannose

UTI fewer, comfort better

Pain/symptoms lower, -21% UTI

Moderate
757
Butterbur

Similar symptom relief

Better than placebo

Moderate
116
Ribose

Filling/QoL: +50 pts

Exercise: +28 W, +1.8 min

Weak
2067
Lupin

HbA1c −2.9%, comfort ↑

Weight −7.4kg, comfort ↑

Weak
20312
Larch

Fewer colds

Worse onset symptoms

Weak
144
Gamboge

Mood/anxiety/function +4.2

Post-stop worsening

Weak
2710
Devil's Claw

Less pain, less stiffness

+pressure tolerance

Weak
29