Proof.Fit

Vascular health

22 supplements analyzed and ranked by clinical evidence.

Supplements22

Supplement Evidence

Main Effects
Nitrate

↓BP +nitrite

↑Vasodilation +FMD

Strong
98412
Vitamin C

Endothelial function +FMD

Blood pressure βˆ’7 mmHg

Oxidative stress/CRP βˆ’30%

Strong
151318
Arginine

NO vasodilation +33%

BP/perfusion changes

ADMA/cGMP shifts

Strong
125319
Vitamin K

CAC/AVC ↓ ~6%

Stiffness/PWV ↓, dp-ucMGP ↓

Strong
66214
Phytosterols

LDL/TC ↓, FMD/NO ↑

Oxidative/vascular markers ↓

Strong
30617
N-Acetyl Cysteine

Endothelial function, ICAM/VCAM

-25.4% homocysteine, BP

Nitrate tolerance relief

Strong
62317
Hesperidin

Venous tone/flow ↑

Edema/symptoms ↓

Strong
6416
Rutin

↓ swelling/symptoms

↑ venous function

Strong
8613
Diosmin

Capillary strength +60 mmHg

Venous symptoms -PTS 8.9%

Inflammation/edema improved

Strong
598
Pine Bark Extract

Endothelial function +41%

Venous swelling/thrombosis ↓

Strong
5318
Red Yeast Rice

LDL/FMD: -22%

Inflammation/stiffness: -12%

Vascular events: -51%

Moderate
6814
Grape Seed Extract

Blood pressure/endothelial +6.4

Venous reflux/bleeding -2490 ms

Moderate
4413
Black Currant

Endothelial function +28%

Blood pressure -6 mmHg

Moderate
5113
Bergamot

↓ LDL-C, improved dilation

↓ LOX-1/hs-CRP

Moderate
3515
Horse Chestnut

Edema -44 mL

Venous measures improved

Moderate
88
Butcher's Broom

Venous tone, -1.25 mm

Swelling/symptoms, p<0.01

Moderate
45
Spermidine

Endothelium +RHI 0.31

Nitric oxide, spermidine

Weak
2611
Blueberry Extract

Memory,+0.055

Blood pressure,βˆ’6.99 mmHg

Weak
610
Hawthorn

Inflammation/endothelium -0.33

+SIRT1 +1.41

Weak
16016
Nattokinase

BP reduced βˆ’5.55/βˆ’2.84

Renin activity lowered βˆ’1.17

Weak
85
Zeaxanthin

Lipid/anti-inflammatory: HDL, OxLDL

Vascular flow: +60 AU; BP -4/-4

Weak
1567
Pumpkin Seed Oil

HDL +16%, BP -5.4

Wave reflection, BP ↓

Weak
58