Proof.Fit

Alertness

32 supplements analyzed and ranked by clinical evidence.

Supplements32

Supplement Evidence

Main Effects
Caffeine

Alertness +, RT↓

Blood pressure +, alertness +

Strong
73611
Phenylethylamine

Catecholamine boost

Sleepiness/alertness shift

+52% intubation

Strong
357511
Nicotine

Alertness+RT

Craving+HR

Strong
286215
Melatonin

Earlier sleep onset + alertness

Sleep quality + sleepiness

Strong
6547
L-Tyrosine

Alertness ↑; cognition

Tyrosine depletion ↓ alertness

Strong
325211
Phenylalanine

Alertness ↓, RT slower

Alertness ↑, RT faster

Strong
110316
Carnitine

Memory/attention +p<0.05

Fatigue/alertness +MMSE

+ammonia cognition EEG

Strong
47518
Ephedrine

Less sedation, alertness up

BIS up, alertness lighter

Moderate
56213
Acetyl-L-Carnitine

Memory/attention +

Fatigue/cognition +

Moderate
9017
Panax Ginseng

Attention/working memory +

Fatigue/stress -2.7 to -4.3

Moderate
21518
Ginkgo Biloba

Alertness: faster processing

Alertness: improved attention +31ms

Moderate
22317
Yohimbine

Alertness↑ stress

Alertness↑ panic

Moderate
798
Rauwolscine

Alertness/anxiety ↑

Autonomic activation ↑

Panic/startle ↑

Moderate
8310
Valerian

Alertness: - first hours

Alertness: no next-day

Moderate
367
Oxiracetam

Attention + cognition

Reaction time +8.97

Memory + alertness

Moderate
139
Piracetam

Attention/cognition +0.73 z

EEG vigilance, hypoxia

Moderate
15510
Theanine

Alertness/attention +ms

Alertness/stress βˆ’tiredness

Alertness/RT βˆ’28ms

Moderate
3915
Theobromine

Improved alertness, cognition

-21β†’107 ml/min

Moderate
29412
Guarana

Attention/RT faster -8.5%

Mental fatigue lower

Moderate
169
Galantamine

Attention/RT +p<0.05

Sleepiness βˆ’7.1

EEG alpha/theta βˆ’15%

Moderate
11010
Citicoline

Attention/orientation +

EEG arousal shifts

Weak
7614
Huperzine A

Alertness up: +4.6

+2.7 MMSE

AChE down >50%

Weak
129
NADH

Cognition, sleepiness +29%

Memory/fluency preservation

Attention lapses reduced

Weak
15716
Eleuthero

Memory + stress ↓

Attention/speed/accuracy ↑

Weak
2011
Green Tea Extract

Attention/memory +

Relaxed alertness

Weak
24417
Vinpocetine

CGI/SKT improved

Severity decreased

Weak
188
Dendrobium

BP +3–5 mmHg

Energy/focus ↑

Weak
36
Bitter Orange

Speed/attention, alertness +5.9%

CBF/processing speed, DSST improved

Verbal memory +6.3%

Weak
25113
L-Histidine

Fatigue ↓; alertness ↑

Cognition +0.21

Weak
15916
Matcha

Attention + fast RT

Cognition maintained -2.2

Weak
1113
Siberian Ginseng

Attention/speed/accuracy improved

Errors trended down

Weak
2111
Adrafinil

Locomotion/exploration ↑

Sniffing ↓ over time

Weak
12